DEVELOPMENT OF TECHNOLOGY AND METHODS OF CONTROL OF BIFUNCTIONAL OINTMENT

A new bifunctional ointment with chondroitin sulfate and celecoxib on a hydrophilic base was developed. The optimum conditions of the technology and technological properties of the ointment were determined. The techniques for quantitativecontrol of active components in a bifunctional ointment are developed. Quantitative determination of chondroitin sulfate in an ointment was conducted by turbidimetric titration. A relative error of determination with confidence probability P=95% is not more than 2,01%. Quantitative determination of celecoxib was conducted by spectrophotometry. A relative error of determination with confidence probability P=95% is not more than 3,22%

DEVELOPMENT AND VALIDATION THE METHOD OF QUANTITATIVE DETERMINATION OF ETORICOXIB IN SOLID PHARMACEUTICAL FORMS BY HPLC

A sensitive and developed the validation method for quantification by using the chromatograph for Etoricoxib. The method was validated in terms of specificity, linearity, accuracy, precision and analytical range. The results of validation method and approbation at selected sites are given. It was shown than main validation characteristics meet the requirements. Using the HPLC method the dispersion was 0,253%. The analytical range of method is 25-85 µg/ml for HPLC