Conversational contexts:Investigating the dynamics of relationships between clients and professionals in child welfare

The effectiveness of interventions has become an important object of scientificstudy in child welfare and often a prerequisite for funding of child welfare programmes. Many studies on the effectiveness of interventions aimed at supporting families at risk and behavioural change of youth have suggested that features of the relationship between professional and client, and the characteristics of the professional, are decisive for the interventions’ effectiveness. There are, however, few studies of what is important in terms of relational skills, personal characteristics or communication strategies. In this special issue, we focus on the dynamics of relationships between child welfare workers and clients (i.e. young people and/or their parents) by using direct observation and close analysis of naturally occurring processes. The contributions to this special issue have a ‘bottom up’ and a ‘top down approach’ in analysing relationships. The first part uses a ‘bottom up’ approach and reports on conversations between youth and family treatment parents in treatment homes. Using a ‘top down’ approach, the second part specifically focuses on Motivational Interviewing skills of care professionals in their interactions with youth. The third part covers the interactions between parents and professionals in the context of child protection using a ‘bottom up’ approach

Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways

The recent outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has led to a worldwide pandemic. One week after initial symptoms develop, a subset of patients progresses to severe disease, with high mortality and limited treatment options. To design novel interventions aimed at preventing spread of the virus and reducing progression to severe disease, detailed knowledge of the cell types and regulating factors driving cellular entry is urgently needed. Here we assess the expression patterns in genes required for COVID-19 entry into cells and replication, and their regulation by genetic, epigenetic and environmental factors, throughout the respiratory tract using samples collected from the upper (nasal) and lower airways (bronchi). Matched samples from the upper and lower airways show a clear increased expression of these genes in the nose compared to the bronchi and parenchyma. Cellular deconvolution indicates a clear association of these genes with the proportion of secretory epithelial cells. Smoking status was found to increase the majority of COVID-19 related genes including ACE2 and TMPRSS2 but only in the lower airways, which was associated with a significant increase in the predicted proportion of goblet cells in bronchial samples of current smokers. Both acute and second hand smoke were found to increase ACE2 expression in the bronchus. Inhaled corticosteroids decrease ACE2 expression in the lower airways. No significant effect of genetics on ACE2 expression was observed, but a strong association of DNA- methylation with ACE2 and TMPRSS2- mRNA expression was identified in the bronchus.</p

Transcendental-Phenomenological Proof and Descriptive Metaphysics

Following P.F. Strawson's reading of Kant, the majority of the literature on transcendental arguments seeks to divorce such arguments from their original Kantian context. This thesis is concerned with Mark Sacks's recent defence of transcendental arguments, which takes a different approach. A critique is given of Sacks's work and extensions and modifications of his approach are recommended. It is proposed that certain difficulties encountered by Kant's transcendentally-ideal approach can be overcome with Hegelian solutions