The experience of neural network prediction of the need for surgical treatment in patients with the diseases of hepatopancreatoduodenal zone

Aim. Using multilayer perceptron artificial neural network, to develop a mathematical model for predicting the need for surgical intervention in patients admitted for hepatopancreatoduodenal zone diseases and to assess the capabilities for its clinical application. Methods. The study was performed using the data of 488 patients with peptic ulcer, cholecystitis or pancreatitis, analyzed using multilayer perceptron artificial neural network, trained to distinguish vectors of data on risk factors of patients who did or did not require surgical intervention during current hospitalization. Results. Patients in the training sample who had required surgical intervention during hospitalization were different from patients who had undergone conservative treatment by such characteristics as gender, age, duration of the disease, state on admission, and the structure of risk factors. The acquired data made it possible to train the artificial neural network. The ROC analysis of the mathematical model demonstrated the area under the curve (AUC) equal to 0.880 for the training group (n=385) and 0.739 for the clinical approbation group (n=103). Conclusion. The AUC indicators of the created model can be characterized as very good in terms of predicting the need for surgical treatment in the training group and good for the clinical approbation group: sensitivity and specificity of the model exceed 80% in the training group and are highest in patients with peptic ulcer disease; in the clinical approbation group these parameters were lower as expected, however, remained at the level of 60-70%

Special features of the 9^9Be→\to2He fragmentation in emulsion at an energy of 1.2~A~GeV

The results of investigations of the relativistic $^9$Be nucleus fragmentation in emulsion which entails the production of two He fragments of an energy of 1.2~A~GeV are presented. The results of the angular measurements of the $^9$Be$\to$2He events are analyzed. The $^9$Be$\to^8$Be+n fragmentation channel involving the $^8$Be decay from the ground (0$^+$) and the first excited (2$^+$) states to two $\alpha$ particles is observed to be predominant.Comment: 10 pages, 6 figures, conference: Conference on Physics of Fundamental Interactions, Moscow, Russia, 5-9 Dec 2005 (Author's translation

Reference information in integral anamnesis development

The article is devoted to semantic content of integral anamnesis - basic part of national integrated electronic health record. Integral anamnesis is a formalized set of the most important clinical data of a patient aimed at safety and continuous medical care both emergency and elective care. A short review of international projects of implementation and trans border exchange of key information about a patient is presented. Information content of integral anamnesis is presented which is developed in our country and includes 15 main sections: disability, benefits, social factors, addiction and occupational hazards, significant vital parameters, blood types and rhesus factor, pathological reactions, vaccination and immunization, epidemiological anamnesis, significant (dispensary) diseases, surgical interventions, medical devices and implants, pregnancies and deliveries, current medications and non-drug treatment. Administration, structure, problems, readiness of reference materials for coding of information presented in integral anamnesis are described. At the moment most of the necessary reference materials are finished and available on the portal of normative-reference information of the Ministry of Health of the Russian Federation (http://nsi.rosminzdrav.ru/): 20 basic and 7 additional ones. At the current stage it provides interoperability of medical information systems in integral anamnesis. Such time-consuming reference books as surgical interventions, instrumental diagnostic studies, federal reference book of medications are being actively developed. The section «Epidemiological anamnesis of a patient» stays practically unformalized. The first step in this direction is development of a reference book of immunobiological medications for specific prophylaxis, diagnosis and treatment. The aim of the study of semantic interoperability for integral anamnesis was reached by development of 27 reference books posted on the federal portal of normative-reference information of the Ministry of Health of Russia; the next stage should be development of technologies of formation and upgrade of the information of integral anamnesis

PRIMORSKY CENTRE FOR LOCAL ELEMENTAL AND ISOTOPIC ANALYSES OF FEGI FEB RAS: EXPERIENCE OF THE FUNCTIONING AND MAIN AREAS OF RESEARCH

The Shared Research Facilities "Primorsky Centre for Local Elemental and Isotopic Analyses" was created based on the instrumental base of the Far Eastern Geological Institute of the Far Eastern Branch of the Russian Academy of Sciences. The Shared Research Facilities conducts its own (for the needs of FEGI FEB RAS) fundamental and applied scientific research to establish the elemental, isotopic composition and structure of both natural and artificial objects, as well as jointly with other scientific Russian and foreign institutions and universities, industrial enterprises, state and private companies that require modern, precision methods for analyzing various substances and materials, diagnosing and monitoring the condition and changes in the environment

Fragmentation of relativistic nuclei in peripheral interactions in nuclear track emulsion

The technique of nuclear track emulsions is used to explore the fragmentation of light relativistic nuclei down to the most peripheral interactions - nuclear "white" stars. A complete pattern of therelativistic dissociation of a $^8$B nucleus with target fragment accompaniment is presented. Relativistic dissociation $^{9}$Be$\to2\alpha$ is explored using significant statistics and a relative contribution of $^{8}$Be decays from 0$^+$ and 2$^+$ states is established. Target fragment accompaniments are shown for relativistic fragmentation $^{14}$N$\to$3He+H and $^{22}$Ne$\to$5He. The leading role of the electromagnetic dissociation on heavy nuclei with respect to break-ups on target protons is demonstrated in all these cases. It is possible to conclude that the peripheral dissociation of relativistic nuclei in nuclear track emulsion is a unique tool to study many-body systems composed of lightest nuclei and nucleons in the energy scale relevant for nuclear astrophysics.Comment: 15 pages, 4 figures, 4 tables, conference: Relativistic nuclear physics: from Nuclotron to LHC energies, Kiev, June 18-22, 200

Electromagnetic dissociation of relativistic 8^8B nuclei in nuclear track emulsion

Experimental data on fragmentation channels in peripheral interactions of $^8$B nuclei in nuclear track emulsions are presented. A detailed analysis made it possible to justify selections of events of the electromagnetic-dissociation process $^8$B $\to^7$Be + \emph{p} and to estimate its cross section. Events of $^{10}$C peripheral dissociation that were observed in the same exposure are described.Comment: 12 pages, 10 figures, 4 tables, Published in Phys.Atom.Nucl.72:690-701,200

Exposure of Nuclear Track Emulsion to a Mixed Beam of Relativistic 12^{12}N, 10^{10}C, and 7^7Be Nuclei

A nuclear track emulsion was exposed to a mixed beam of relativistic $^{12}$N, $^{10}$C, and $^7$Be nuclei having a momentum of 2 GeV/$c$ per nucleon. The beam was formed upon charge exchange processes involving $^{12}$C primary nuclei and their fragmentation. An analysis indicates that $^{10}$C nuclei are dominant in the beam and that $^{12}$N nuclei are present in it. The charge topology of relativistic fragments in the coherent dissociation of these nuclei is presented.Comment: ISSN 1063-7788, Pleiades Publishing, Ltd., 201

Clustering in light nuclei in fragmentation above 1 A GeV

The relativistic invariant approach is applied to analyzing the 3.3 A GeV $^{22}$Ne fragmentation in a nuclear track emulsion. New results on few-body dissociations have been obtained from the emulsion exposures to 2.1 A GeV $^{14}$N and 1.2 A GeV $^{9}$Be nuclei. It can be asserted that the use of the invariant approach is an effective means of obtaining conclusions about the behavior of systems involving a few He nuclei at a relative energy close to 1 MeV per nucleon. The first observations of fragmentation of 1.2 A GeV $^{8}$B and $^{9}$C nuclei in emulsion are described. The presented results allow one to justify the development of few-body aspects of nuclear astrophysics.Comment: 7 pages, 8 figures, 3 tables, Nuclear Physics in Astrophysics-2, 16-20 May, 2005 (ATOMKI), Debrecen, Hungar

Topology of "white" stars in relativistic fragmentation of light nuclei

In the present paper, experimental observations of the multifragmentation processes of light relativistic nuclei carried out by means of emulsions are reviewed. Events of the type of "white" stars in which the dissociation of relativistic nuclei is not accompanied by the production of mesons and the target-nucleus fragments are considered. A distinctive feature of the charge topology in the dissociation of the Ne, Mg, Si, and S nuclei is an almost total suppression of the binary splitting of nuclei to fragments with charges higher than 2. The growth of the nuclear fragmentation degree is revealed in an increase in the multiplicity of singly and doubly charged fragments with decreasing charge of the non-excited part of the fragmenting nucleus. The processes of dissociation of stable Li, Be, B, C, N, and O isotopes to charged fragments were used to study special features of the formation of systems consisting of the lightest $\alpha$, d, and t nuclei. Clustering in form of the $^3$He nucleus can be detected in "white" stars via the dissociation of neutron-deficient Be, B, C, and N isotopes.Comment: 20 pages, 3 figures, 9 tables, conference: Conference on Physics of Fundamental Interactions, Moscow, Russia, 1-5 Mar 2004.(Author's translation