TREATMENT OF RHEUMATIC DISEASES INTERRELATION OF SELECTIVE NON-STEROIDAL ANTIINFLAMMATORY DRUG CELEBREX (CELECOXIB) AND INHIBITOR OF ENZYME WITH APF ENAP (ENALAPR1L) IN PATIENTS WITH RHEUMATIC DISEASES AND CONCOMITANT ARTERIAL HYPERTENSION

Objective. To assess the effect of selective NSAID Celecoxib on the indices of arterial pressure in RD pts with concomitant arterial hypertension and taking Enalapril. Material and methods. 10 pts (5-RA, 5 - OA) had daily monitoring of arterial pressure, assessment of renal functions against background of Celecoxib and Enalaplir therapy. Results. During combined therapy by Celecoxib and Enalapril arterial pressure, levels of creatinine and blood urine, minute diuresis, speed of glomerulal filtration was not practically changed. Nevertheless in 3 pts considerable increase of arterial pressure was observed. Conclusion. The majority of pts did not demonstrate negative Celecoxib effect on hypotensive Enalapril properties, the third of pts demonstrated increase of daily monitoring of arterial pressure, no negative effect on renal function was found

Traditional cardiovascular risk factors and atherosclerosis in patients with systemic sclerosis

Objective. To assess frequency of traditional cardiovascular risk factors, clinical and subclinical atherosclerosis features in patients with systemic sclerosis (SS).Material and methods. 70 pts with definite diagnosis of SS ( 66 female and 4 male with mean age 46±10,8 years) were included. Control group consisted of 50 relatively healthy volunteers without systemic rheumatic diseases and Raynaud’s phenomenon, matched on sex and age. Classic risk factors of atherosclerosis were analyzed. Total coronary risk (TCR) (10-years risk of cardiovascular catastrophes development) was assessed with Framingham scale. Carotid sonographic examination with intima-media complex thickness (IMT) measurement using a 7.5 MHz frequency linear transducer was performed in 60 SS pts and 45 volunteers with Voluson 730 Expert apparatus (Austria).Results. Frequency of traditional cardiovascular risk factors and TCR was comparable in in SS pts and control. Menopause was more frequent in SS pts (p=0,005). Coronary heart disease was more frequent SS pts (13% versus 2%, p<0,05). Mean triglyceride level in SS pts was significantly higher than in the control group (p<0,001). There was a tendency to increase of IMTmax and IMT thickening in SS compared with control group. Atherosclerotic plaques were present in 10% of SS pts and were absent in control group. IMTmean and IMTmax positively correlated with age of SS pts (p<0,001; p<0,001) and TCR (p<0,001, p=0,001). IMTmean correlated with disease duration (p<0,05) and cholesterol level (p<0,05) in SS pts.Conclusion. Frequency of clinical and subclinical atherosclerosis features in SS pts was higher than in the control group but frequency of main cardiovascular risk factors did not significantly differ. It is possible that generalized SS angiopathy predisposes to vascular atherosclerosis development in SS pts