Chemical investigation of Indian lichens. Part XXI. Occurrence of fallacinal in Teloschistes flavicans

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Nuclear oxidation in the flavone series. Part IX. Oxidation of related chalkones

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Nuclear oxidation in the flavones and related compounds. Part XIV. Constitution of quercetagitrin

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Cancer in the Sindhi population of greater Bombay

The Sindhis are a Hindu subgroup identified by their place of origin and their written spoken language. These are the people who were originally inhabitants of the Province of Sind, which formed a part of the large Bombay Presidency in Undivided India before 1947. The Sindhi Hindus migrated en masse to India after partition. An attempt has been made here to examine the differences found in the site-specific cancer risks among the Sindhi community, the other Hindu groups (such as the Marathi and Gujrati populations) and the Parsi community of Greater Bombay. As the Indian Census Board does not provide age distribution details for the Sindhis, analysis of the data was undertaken employing frequency ratios. Age-standardized cancer ratios (ASCAR) were also utilized for certain calculations. The common sites of cancer appear to vary greatly between the total Bombay population and the Sindhi group. In Sindhi men, for example, cancers of the lung, large bowel, prostate, kidneys and leukemias are most commonly seen, whereas laryngeal and oesophageal cancers predominate in the general population of Bombay. In Sindhi women the breast, uterus, ovary, and skin are the preferred sites, whereas cancers of the cervix and leukemias are predominant in the general population of Bombay. It is interesting to note that there is a degree of similarity in the incidence of cancer at certain anatomical sites, such as the prostate, large intestine, and leukemias in males, and breast, cervix, ovary and uterus in females, between the Sindhi and Parsi communities of Greater Bombay

A new effect of hydrogen bond formation (chelation) Part VI. Synthesis of 5-hydroxy-2'-methoxy flavanone and 5:7-dihydroxy-2'-methoxy flavanone

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A new effect of hydrogen bond formation (chelation) Part IV. Abnormal behaviour of 2'-hydroxy flavanones

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Nuclear oxidation in the flavone series. Part VI. A new synthesis of calycopteretin and 6: 8-dihydroxy-quercetin

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Synthesis of 5 : 6-hydroxy-flavonols - Part III

The synthesis of 3 : 5 : 6 : 3': 4'-pentahydroxy-flavone was already reported. The lower members of this group of 5 : 6-hydroxy flavonols with one and no hydroxyl group in the side-phenyl nucleus have now been prepared by Kostanecki's method. The characteristic properties are described

Self-similar shear-thickening behavior in CTAB/NaSal surfactant solutions

The effect of salt concentration Cs on the critical shear rate required for the onset of shear thickening and apparent relaxation time of the shear-thickened phase, has been investigated systematically for dilute CTAB/NaSal solutions. Experimental data suggest a self-similar behavior of the critical shear rate and relaxation time as functions of Cs. Specifically, the former ~ Cs^(-6) whereas the latter ~ Cs^(6) such that an effective Weissenberg number for the onset of the shear thickened phase is only weakly dependent on Cs. A procedure has been developed to collapse the apparent shear viscosity versus shear rate data obtained for various values of Cs into a single master curve. The effect of Cs on the elastic modulus and mesh size of the shear-induced gel phase for different surfactant concentrations is discussed. Experiments performed using different flow cells (Couette and cone-and-plate) show that the critical shear rate, relaxation time and the maximum viscosity attained are geometry-independent. The elastic modulus of the gel phase inferred indirectly by employing simplified hydrodynamic instability analysis of a sheared gel-fluid interface is in qualitative agreement with that predicted for an entangled phase of living polymers. A qualitative mechanism that combines the effect of Cs on average micelle length and Debye parameter with shear-induced configurational changes of rod-like micelles is proposed to rationalize the self-similarity of SIS formation.Comment: 27 pages, 17 figure

Interferon Gamma-Dependent Intestinal Pathology Contributes to the Lethality in Bacterial Superantigen-Induced Toxic Shock Syndrome

Toxic shock syndrome (TSS) caused by the superantigen exotoxins of Staphylococcus aureus and Streptococcus pyogenes is characterized by robust T cell activation, profound elevation in systemic levels of multiple cytokines, including interferon-γ (IFN-γ), followed by multiple organ dysfunction and often death. As IFN-γ possesses pro- as well as anti-inflammatory properties, we delineated its role in the pathogenesis of TSS. Antibody-mediated in vivo neutralization of IFN-γ or targeted disruption of IFN-γ gene conferred significant protection from lethal TSS in HLA-DR3 transgenic mice. Following systemic high dose SEB challenge, whereas the HLA-DR3.IFN-γ+/+ mice became sick and succumbed to TSS, HLA-DR3.IFN-γ−/− mice appeared healthy and were significantly protected from SEB-induced lethality. SEB-induced systemic cytokine storm was significantly blunted in HLA-DR3.IFN-γ−/− transgenic mice. Serum concentrations of several cytokines (IL-4, IL-10, IL-12p40 and IL-17) and chemokines (KC, rantes, eotaxin and MCP-1) were significantly lower in HLA-DR3.IFN-γ−/− transgenic mice. However, SEB-induced T cell expansion in the spleens was unaffected and expansion of SEB-reactive TCR Vβ8+ CD4+ and CD8+ T cells was even more pronounced in HLA-DR3.IFN-γ−/− transgenic mice when compared to HLA-DR3.IFN-γ+/+ mice. A systematic histopathological examination of several vital organs revealed that both HLA-DR3.IFN-γ+/+ and HLA-DR3.IFN-γ−/− transgenic mice displayed comparable severe inflammatory changes in lungs, and liver during TSS. Remarkably, whereas the small intestines from HLA-DR3.IFN-γ+/+ transgenic mice displayed significant pathological changes during TSS, the architecture of small intestines in HLA-DR3.IFN-γ−/− transgenic mice was preserved. In concordance with these histopathological changes, the gut permeability to macromolecules was dramatically increased in HLA-DR3.IFN-γ+/+ but not HLA-DR3.IFN-γ−/− mice during TSS. Overall, IFN-γ seemed to play a lethal role in the immunopathogenesis of TSS by inflicting fatal small bowel pathology. Our study thus identifies the important role for IFN-γ in TSS