Triggers and markers of skin aging in women with menopausal syndrome

Introduction. External manifestations of aging, and especially skin aging are the most important for modern women.Aim. The aim of our study was to identify a set of adverse factors that effect on the skin of women in menopausal transition (MP) and in postmenopause (PM), and to identify markers of skin aging in this category of women.Materials and methods. The study included 36 women in MP and PM suffering from MS. At the first stage, anamnesis was collected, anthropometric data and severity of MS were evaluated, and the hormonal profile of patients was determined. At the second stage, computer mapping of the skin was performed using the digital video camera Aramo SG with the skin XPpro program. Statistic analysis was performed using the SPSS v13.0 program. Spearman’s analysis was used to determine the relationship between anthropometric, clinical and anamnestic data and the measurements of skin condition of women in MP and PM. Results. According to the obtained data, the main triggers of skin aging of women in MP and PM are: the presence of metabolic disorders (obesity, metabolic syndrome), decrease of estradiol and progesterone levels in blood serum as well as increase of prolactin level and rhythm disturbance of melatonin secretion. Markers of skin aging in women with menopausal syndrome are decreased moisture, increased oiliness in T-zone, increased of skin pigmentation and enlarged pore size.Conclusions. The obtained data are useful for management involuting skin changes of women in PM and MP suffering from MS. The data justifies the relevancy to normalization not only the estradiol level, but other sex steroids, melatonin, as well as correction of metabolic endocrine processes, and treatment of MS

CHARACTERISTICS OF IMMUNE HOMEOSTASIS IN PATIENTS WITH BASAL CELL SKIN CANCER FROM KOPEYSK URBAN DISTRICT

Patterns of immune response, cytokine- and NO-ergic mechanisms and their role in the development of basal-cell skin cancer were evaluated in population of an industrialized region. Multiple forms of basal-cell skin cancer and primary multiple cancer were characterized by the evidence of Th2-dependent imbalance of immune response, decreased cytolytic potential, increase of EGF, TGF-β, IL-1β, IL-4, IFNγ, lactoferrin levels, thus suggesting a particular immune defense strategy in malignant growth

Seborrheic keratosis: clinical characteristics and an association with the β-genus human papillomavirus

Background: Seborrheic keratosis is a  common benign tumor of unclear etiology. Aim: To study associations between clinical characteristics of seborrheic keratosis and its course with quantitative parameters of the β-genus human papillomavirus (β-HPV). Materials and methods: The main study group included 91 patients with seborrheic keratosis (29 male and 62 female), aged 40 to 75  years (mean ± SD, 59.2 ± 6.4 years). The control group included 30 healthy individuals persons aged 40 to 70 years (mean 57.6 ± 4.1 years). The diagnosis of seborrheic keratosis was confirmed by dermoscopy and pathomorphological assessment, with 100% of patients having the acanthotic type of seborrheic keratosis. HPV was identified by polymerase chain reaction with hybridization fluorescent detection in real time mode with use of three oligonucleotide systems for detection of HPV genus β1 (subtypes 5, 8, 12, 14, 19, 21, 25, 36, 47); β2 (subtypes 9, 15, 17, 22, 23, 37, 38, 80), and β3 (subtypes 49, 75, 76). Results: The most frequent clinical type of seborrheic keratosis was the maculopapular one (61/91 patients, 67%) localized mainly on head, neck, anterior and posterior trunk. β-HPV was found in 88.8% biopsy samples taken from the seborrheic keratosis areas in 24 of 27 patients and in 66.6% biopsy samples taken from the normal skin areas of the same patients (р = 0.04). This is significantly more frequent that the HPV contamination among healthy individuals, which was 28.7% (р = 0.02). Mixed association of β-HPV was also more frequent in the HPV-positive patients (21/24, or 83.3%; compared to the control group, р = 0,00001). The maximal (significant) viral load was found in the subgroup of seborrheic keratosis patients with the number of proliferative lesions of 10 and more (4.08 ± 0.3 lg/105 tо 5.7 ± 0,3 lg/105). Conclusion: The maculopapular type of seborrheic keratosis is characterized by mixed HPV β1, β2, β3 infection found in 77.7% of cases irrespective of the number of proliferative lesions. It could be hypothesized that multiple seborrheic keratosis (more than 10 lesions) develops in simultaneous presence of HPV β1, β2, β3 and is associated with a  higher probability of new seborrheic keratosis lesions on intact skin

The results of treatment of hemangiomas in children apparatus «Multiline» (Nd:YAP Q-Sw/KTP)

Трапезникова Т.В., руководитель научно- экспертного отдела, сеть клиник «Линлайн» (г. Челябинск), [email protected] Trapeznikova T.V., the Head of Scientific Research and Examination Department of Linline Clinic Net (the city of Chelyabinsk), [email protected]. Писклакова Т.П., доктор медицинских наук, профессор кафедры дерматовенерологии, Челябинская государственная медицинская академия. Pisklakova T.P., Doctor of Medical Sciences (Grand MD), Professor of Dermatology and Venereology Department, Chelyabinsk State Medical Academy.Представлен метод лазерной коагуляции сосудов аппаратом «Мультилайн» (Nd:YAPQ-Sw/KTP) фирмы LinlineGmbH (Германия). Дана характеристика принципов воздействия и его основные преимущества в лечении гемангиом. Проведено лечение гемангиом у 34 детей в возрасте 1–24 месяцев, определены параметры лазерного излучения, количество и режим процедур, выявлена эффективность данной методики. Полученные результаты (побледнение и уменьшение толщины сосудистой опухоли, отсутствие осложнений, относительная безболезненность) позволяют рассматривать лазерное лечение гемангиому детей аппаратом «Мультилайн» (Nd:YAPQ-Sw/KTP) как наиболее эффективный, безопасный метод. The method of laser coagulation of vessels apparatus «Multiline» (Nd:YAP Q-Sw/KTP) of the firm «LinlineGmbH» Germany. Given the characteristics of the principles of the impact and its major benefits in the treatment of hemangiomas. The treatment of hemangiomas in 34 children in the age of 1–24 months, determined the parameters of laser radiation, the number and mode of procedures, revealing the effectiveness of this technique. The obtained results (blanching and a reduction in the thickness of vascular tumors, absence of complications, relative painless) allow to consider laser treatment of hemangiomas in children Nd:YAP Q-Sw/KTP apparatus «Multiline» as the most effective and safe method of treatment in children