Role of anaerobic microflora in the pathogenesis of odontogenic phlegmons

The role of anaerobic microflora in the pathogenesis of maxillofacial diseases, particularly odontogenic phlegmons, was investigated. Based on the results the role of pathogens in the etiology and pathogenesis of odontogenic phlegmons is shown. RT PCR used as a research method.Проведено изучение роли анаэробной микрофлоры в патогенезе гнойно-воспалительных заболеваний челюстно-лицевой области, в частности одонтогенных флегмон. Исследование сделано на основе методики полимеразной цепной реакции с детекцией результатов в режиме реального времени. На основании полученных данных показана роль групп аэробных и анаэробных микроорганизмов в этиологии и патогенезе одонтогенных флегмон

Evaluation of the qualitative and quantitative composition of or al microbiota in patients with medial osteonecrosis of the jaw

Aim. To determine  the qualitative and quantitative composition  of the oral microbiota in patients with medial osteonecrosis of the jaw (MOJ). Materials and methods. Microbiota was evaluated in 15 patients with medial osteonecrosis of the jaw. An assessment was made of 12 groups of optional and obligate-anaerobic microorganisms.  Evaluation of the qualitative and quantitative  composition  of oral microbiota  in patients with MOJ was performed by real-time polymerase chain reaction (PCR-RT). Results. The aerobic-anaerobic microbiota composition in patients with MOJ in the oral fluid and separated from the fistula is presented. The values of the total bacterial mass (TBM) and all anaerobic microorganisms  in the oral fluid in patients with MOJ before treatment were higher by 1-3 orders of magnitude than in healthy individuals. In the jaw, separated from the fistula in the zone of necrosis of the jaw, these parameters  were higher by 2-4 orders than in the oral fluid. Prior to surgery, a course of antibiotic  therapy was conducted  for 7 days. As a result of the therapy,  the parameters  of anaerobic  microflora  in the oral fluid decreased.  The use of cefazolin was more effective than lincomycin.  In 1 year after surgical treatment, the index of TBM and the indices of anaerobic  microorganisms  did not  differ from those of healthy  individuals. Conclusion. Patients  with medical osteonecrosis of the jaw have a high level of anaerobic pathogens in the oral microbiota. The course of antibiotic  therapy and surgical intervention  are effective methods  of treatment of MOJ,  as they lead to effective sanation, and allow further endoprosthetics