Kinetics and mechanism of halogenation of aniline, p-toluidine and o-toluidine using N-chloro-p-toluene sulphonamide (CAT) under buffer conditions in ethanol -water mixtures

Abstract: Kinetics of halogenation of aniline, p-toluidine and o-toluidine have been investigated by using N- Keywords: Halogenation , CAT , Amines , Reactivity of amines Aim: The present work deals with the halogenation of aromatic amines (Aniline, o-toluidine and p-toluidine) in ethanol -water mixture by CAT. Background

Synthesis of β-amino alcohols by ring opening of epoxides with amines catalyzed by sulfated tin oxide under mild and solvent-free conditions

One significant and elegant method for creating β-amino alcohols, which are useful intermediates for the synthesis of many different natural and synthetic pharmaceutical compounds, is to open the rings of epoxides with amines. When sulfated tin oxide catalyst (2 mol%) is present, epoxides can open their rings and react with amines to produce corresponding β-amino alcohols in good to high yields under mild circumstances. Under clean circumstances and in a short amount of time, the reaction demonstrated high regioselectivity and functioned well with both aromatic and aliphatic amines at room temperature

A NEW RELATED SUBSTANCES METHOD DEVELOPMENT AND VALIDATION OF TWO ANTI-CANCER DRUGS BY USING EFFECTIVE LIQUID CHROMATOGRAPHIC METHOD

Objective: The present study was aimed at developing and successively validating novel, simple, responsive and stable RP-HPLC method for the measurement of active pharmaceutical ingredients of mitomycin and fluorouracil and their related substances. Methods: Using the impurity-spiked solution, the chromatographic approach was optimized. The chromatographic method used Luna C18 column of dimensions 150x4.6 mn, 3.5 μm, using gradient elution with a mobile phase of acetonitrile and 0.1 percent orthophosphoric acid. A flow rate of 1 ml/min and a detector wavelength of 260 nm using the PDA detector was provided in the instrumental settings. Recovery, specificity, linearity, accuracy, robustness, ruggedness was determined as a part of method validation and the results were found to be within the acceptable range. Results: According to the ICH guidelines, the developed approach was validated. The calibration charts plotted were linear with a regression coefficient of R2>0.999. Conclusion: The method developed was found to be applicable to routine analysis and to be used for the measurement of active pharmaceutical ingredients (i. e, Mitomycin and Fluorouracil and its related impurities). Since there is no HPLC method reported in the literature for the estimation of Mitomycin, Fluorouracil and its related impurities; there is a need to develop quantitative methods under different conditions to achieve improvement in specificity, selectivity etc