Effects of Pretreatment with Clozapine On Spatial Memory of Rats with Lesioned Dorsal Hippocampi

The atypical antipsychotic clozapine improves spatial memory in rats with partial hippocampal lesions. However, the effectiveness of treatment with clozapine before brain injury is unknown. To assess the possibility that chronic pretreatment with clozapine might preserve spatial memory after a hippocampal lesion, we injected rats with either saline or clozapine for one month prior to partial hippocampal lesioning and then assessed spatial learning. Our initial results suggest that pretreatment with clozapine might minimize spatial memory deficits following partial hippocampal lesions. This finding has implications for the prevention and treatment of spatial memory deficits

Il trattamento dell'occlusione intestinale nella nostra esperienza [Treatment of bowel obstruction in our own experience]

The intestinal obstruction accounts for the 20% of the acute surgical affections and represents one of the most common indications for the urgent surgery. The clinical scenarios of the intestinal occlusion are rather diversified, with a series of signs not always contemporary present, since they are related to the site (left colon in most cases) and type (neoplastic, by adhesions, or hernia complication) of the obstruction. The authors report their experience about 149 patients clinically observed and treated along a period of 7 years and 3 months

Sepsi addominali nel malato chirurgico. Fisiopatologia e prevenzione

Abdominal sepsis is a rare but life threatening condition due to several causes. Although several advances in medicine have been performed in last years, abdominal sepsis could have a negative potential evolving beyond exitus. The authors present a review of the literature and a commentary of their own clinical experience

Epatopatie virali croniche ed espressione epatocitaria di oncoproteine (Chronic viral diseases of the liver and oncoproteins externalization in hepatocytes)

Strong interest exists about the biomolecular basis of the chronic liver diseases due to viral infections. It seems to be very interesting because of their evolutive potential. In this context the study of oncogenes and oncoproteins could be interesting as prognostic factors for chronic viral diseases of the liver. In this study the authors show the results obtained about EGF and p62 expression in 39 selected patients with cirrhosis and 3 different chronic viral hepatitis (persistent, lobular, and active)

CLINICAL MANAGEMENT OF THE INFECTIVE ENDOCARDITIS TODAY

The aim of this review is to present current trend in the clinical management of the infective endocarditis (I.E.). This disease has still, to date high mortality. So it is, in spite of the most modem therapeutic approaches based on both the latest generation of antibiotics, and the application of the latest cardiac surgery. Therefore, it is important to focus on the medical and surgical treatment options currently most widely accepted among those available today, on the basis of international consensus and clinical experience acquired so far on this subject. In this article are reviewed these therapeutic modalities. The rapid and accurate diagnosis and prompt and proper implementation of integrated medical and surgical therapies are essential in order to be able to lower as much as possible the mortality of this severe disease

Gardner syndrome: Clinical and epidemiologic up to date [Attualità cliniche nella sindrome di Gardner: Contributo casistico]

In 1950 EJ Gardner first described a new syndrome characterized by 1) familial colonic polyposis, 2) multiple osteomas, 3) soft tissues cysts and 41 fibrous lesions. Thereafter, in 1975 Watne and coll. have demonstrated the occurence, in patients affected by Gardner syndrome, of the early onset of osteomas and dental inclusions in maxillary bones. Gardner syndrome is actually considered a severe life treathening condition due to the poor quality of life and the evolutive pattern of colonic polyps to colon cancer in 100% of cases. The aim of this paper is the review of the pathophysiologic and clinical aspects of Gardner syndrome, with report of institutional clinical data about epidemiology and clinical presentation of such condition, attempting to elaborate a clinical protocol for early detection of that