16 research outputs found
Analysis of olfactory and gustatory sensory abnormalities dynamic among medical students during the COVID-19 pandemic
The aim of study – to study the changes in the frequency of olfactory and/or gustatory analyzer dysfunction among medical students from January 2020 to February 2022.Цель исследования – изучение изменения частоты встречаемости нарушений работы ольфакторного и/или густаторного анализаторов у студентов-медиков в период с января 2020 по февраль 2022 года
ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE G894T POLYMORPHISM IN PATIENTS WITH CORONARY HEART DISEASE AND DIABETES MELLITUS TYPE 2
The aim of the study is to estimate the frequency of occurrence of genotypes and alleles of the G894T polymorphic
variant of the endothelial nitric oxide synthase (eNOS) gene in patients with chronic coronary heart disease (CHD)
and in healthy individuals residing in Grodno region.
Material and methods. A total of 135 patients were examined. Among them there were 65 patients with CHD and
diabetes mellitus (DМ) type 2 and 70 patients with CHD without DM type 2. The control group included 30 otherwise
healthy individuals. Identification of the eNOS gene G894T polymorphism was performed using polymerase chain
reaction.
Results. Distribution of frequencies of genotypes and alleles of the G894T polymorphic variant of the eNOS gene
was revealed in the examined patients as well as in the control group by the results of molecular genetic testing. When
determining the frequency of the G894T polymorphic variant of the eNOS gene in the total sample of patients it was
established that there were 81 (49.1%) carries of the eNOS 894GG genotype, 63 (38.2%) carries of the heterozygous
894GT genotype, and only 21 (12.7%) patients with the 894TT genotype. Frequency of the 894G allele was 68.2%,
while frequency of the 894T allele was 31.8 %.
Conclusion. Statistically significant prevalence of the homozygous 894TT genotype of the G894T polymorphic
variant of the eNOS gene was established in the 1st group of patients (р=0.01) as well as in the 2nd group (р=0.03)
in comparison with the control group. The presence of the 894ТT genotype of the eNOS gene G894T polymorphism
increases the risk of CHD by 1.5 times (95% CI 1.29 – 1.74)