8 research outputs found
ΠΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ
The review provides and describes in detail the main most commonly used behavioral experimental models of depression. Endophenotypes and criteria of validity of behavioral methods for evaluation of antidepressant activity in compounds are described. Modeling depression using laboratory animals allows us to understand the nature of depression in humans and to search for effective ways of treating.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΈ Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ. ΠΠΏΠΈΡΠ°Π½Ρ ΡΠ½Π΄ΠΎΡΠ΅Π½ΠΎΡΠΈΠΏΡ ΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π²Π°Π»ΠΈΠ΄Π½ΠΎΡΡΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π°Π½ΡΠΈΠ΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Ρ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠ½ΡΡΡ ΠΏΡΠΈΡΠΎΠ΄Ρ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡ ΠΏΠΎΠΈΡΠΊ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² Π΅Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠΎΠΏΡΠΈΡ ΠΎΡΡΠΎΠΏΠ½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ Ρ Π½Π΅ΠΉΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ Π΄ΠΈΠΌΠ΅ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠΈΠΌΠ΅ΡΠΈΠΊΠ° 4-ΠΎΠΉ ΠΏΠ΅ΡΠ»ΠΈ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠΎΡΡΠ° Π½Π΅ΡΠ²ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΠ-2h
Dimeric dipeptide mimethic human nerve growth factor, bis-(N-monosucciniL-gLycyL-Lysine), GK-2h at doses 0,1, 0,5, 1,0, 1,5 mg/kg, i.p. has an antiamnesic effect on the modeLs of scopoLamine, maximaL eLectroshock or ketamin induced passive avoidance response amnesia. GK-2h at doses 1,0-1,5 mg/ kg possess weak antihypoxic und anticonvuLsive properties, it does not affect the expLoratory behavior of animaLs in the test of open fieLd.ΠΠΌΠ΅ΡΠ½ΡΠΉ Π΄ΠΈΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΠΉ ΠΌΠΈΠΌΠ΅ΡΠΈΠΊ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠΎΡΡΠ° Π½Π΅ΡΠ²ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠK-2h Π² Π΄ΠΎΠ·Π°Ρ
0,1, 0,5, 1,0, 1,5 ΠΌΠ³/ΠΊΠ³, Π²/Π± ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ Π°Π½ΡΠΈΠ°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΡ
Π°ΠΌΠ½Π΅Π·ΠΈΠΈ ΡΡΠ»ΠΎΠ²Π½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΏΠ°ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠ·Π±Π΅Π³Π°Π½ΠΈΡ, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠΉ ΡΠΊΠΎΠΏΠΎΠ»Π°ΠΌΠΈΠ½ΠΎΠΌ, ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΠΊΠΎΠΌ ΠΈΠ»ΠΈ ΠΊΠ΅ΡΠ°ΠΌΠΈΠ½ΠΎΠΌ, ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Ρ Ρ ΠΊΡΡΡ Π»Π°ΡΠ΅Π½ΡΠ½ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ ΠΏΡΠΈ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠ΅ΡΠ»Π΅ΠΊΡΠ°. ΠK-2h Π² Π΄ΠΎΠ·Π°Ρ
1,0-1,5 ΠΌΠ³/ΠΊΠ³ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ΅ΠΆΠΈΠΌΠ°Ρ
Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ³ΠΈΠΏΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΡΠ΅ΠΊΡΠΎΠΌ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ Ρ Π³ΠΈΠΏΠ΅ΡΠΊΠ°ΠΏΠ½ΠΈΠ΅ΠΉ Π² Π³Π΅ΡΠΌΠΎΠΎΠ±ΡΡΠΌΠ΅ ΠΈ ΡΠ»Π°Π±ΡΠΌ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ΄ΠΎΡΠΎΠΆΠ½ΡΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΡΠ΄ΠΎΡΠΎΠ³, Π²ΡΠ·Π²Π°Π½Π½ΡΡ
ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΠΊΠΎΠΌ ΠΈ Π½Π΅ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²ΠΎΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π² ΠΎΡΠΊΡΡΡΠΎΠΌ ΠΏΠΎΠ»Π΅
Sexual function through decades: association with androgens and cardiometabolic features
Effect of the Samarium Impurity on the Local Structure of Se95Te5 Chalcogenide Glassy Semiconductor and Current Passage through AlβSe95Te5β©SmβͺβTe Structures
Introduction: Dispersed Minorities and Non-Territorial Autonomy
The concept of non-territorial autonomy gives rise to at least two important questions: the range of functional areas over which autonomy extends, and the extent to which this autonomy is indeed non-territorial. A widely used early description significantly labelled this βnational cultural autonomyβ, implying that its focus is mainly on cultural matters, such as language, religion, education and family law. In many of the cases that are commonly cited, βautonomyβ may not even extend this far: its most visible expression is the existence of separate electoral registers or quotas for the various groups. Part of the dilemma lies in the difficulty of devolving substantial power on a non-territorial basis: to the extent that devolved institutions are state-like, they ideally require a defined territory. Ethnic groups, however, vary in the extent to which they are territorially concentrated, and therefore in the degree to which any autonomous arrangements for them are territorial or non-territorial. This article explores the dilemma generated by this tension between ethnic geography (pattern of ethnic settlement) and political autonomy (degree of selfrule), and introduces a set of case studies where the relationship between these two features is discussed further: the Ottoman empire and its successor states, the Habsburg monarchy, the Jewish minorities of Europe, interwar Estonia, contemporary Belgium, and two indigenous peoples, the SaΒ΄mi in Norway and the Maori in New Zealand