Low-lying quadrupole collective states of the light and medium Xenon isotopes

Collective low lying levels of light and medium Xenon isotopes are deduced from the Generalized Bohr Hamiltonian (GBH). The microscopic seven functions entering into the GBH are built from a deformed mean field of the Woods-Saxon type. Theoretical spectra are found to be close to the ones of the experimental data taking into account that the calculations are completely microscopic, that is to say, without any fitting of parameters.Comment: 8 pages, 4 figures, 1 tabl

The assessment of UPF index and colour fastness for textile materials protecting against harmful UV radiation

W ostatnich latach coraz bardziej zwraca się uwagę na zjawiska oddziałujące niekorzystnie na człowieka. Za szczególnie niebezpieczne postrzegane jest promieniowanie z zakresu nadfioletu. Jednym ze sposobów eliminacji lub ograniczenia tego szkodliwego wpływu promieniowania słonecznego jest użytkowanie materiałów tekstylnych o dobrych właściwościach barierowych. W pracy przedstawiono wyniki badań wskaźników UPF i odporności wybarwień dla dzianin wykonanych z przędz naturalnych z udziałem włókien łykowych przeznaczonych na wyroby chroniące przed szkodliwym promieniowaniem UV.In the last years an attention is more and more being returned to occurrences having disadvantageous effect on the human-body. Radiation in ultraviolet range is perceived as most dangerous one. One of the ways of elimination or limitation such harmful influence of the solar radiation is using the textile materials with the good barrier properties. This work presents the results of UPF index and colour fastness for knitted fabrics made of natural yarns with a share of bast fibers designed for products protecting against harmful UV radiation

Modifying immune responses to adeno-associated virus vectors by capsid engineering

De novo immune responses are considered major challenges in gene therapy. With the aim to lower innate immune responses directly in cells targeted by adeno-associated virus (AAV) vectors, we equipped the vector capsid with a peptide known to interfere with Toll-like receptor signaling. Specifically, we genetically inserted in each of the 60 AAV2 capsid subunits the myeloid differentiation primary response 88 (MyD88)-derived peptide RDVLPGT, known to block MyD88 dimerization. Inserting the peptide neither interfered with capsid assembly nor with vector production yield. The novel capsid variant, AAV2.MB453, showed superior transduction efficiency compared to AAV2 in human monocyte-derived dendritic cells and in primary human hepatocyte cultures. In line with our hypothesis, AAV2.MB453 and AAV2 differed regarding innate immune response activation in primary human cells, particularly for type I interferons. Furthermore, mice treated with AAV2.MB453 showed significantly reduced CD8+ T cell responses against the transgene product for different administration routes and against the capsid following intramuscular administration. Moreover, humoral responses against the capsid were mitigated as indicated by delayed IgG2a antibody formation and an increased NAb50. To conclude, insertion of the MyD88-derived peptide into the AAV2 capsid improved early steps of host-vector interaction and reduced innate and adaptive immune responses