Controlled enhancement or suppression of exchange biasing using impurity δ\delta-layers

The effects of inserting impurity $\delta$-layers of various elements into a Co/IrMn exchange biased bilayer, at both the interface, and at given points within the IrMn layer a distance from the interface, has been investigated. Depending on the chemical species of dopant, and its position, we found that the exchange biasing can be either strongly enhanced or suppressed. We show that biasing is enhanced with a dusting of certain magnetic impurities, present at either at the interface or sufficiently far away from the Co/IrMn interface. This illustrates that the final spin structure at the Co/IrMn interface is not only governed by interface structure/roughness but is also mediated by local exchange or anisotropy variations within the bulk of the IrMn

Comparing Cognitive Theories of Learning Transfer to Advance Cybersecurity Instruction, Assessment, and Testing

The cybersecurity threat landscape evolves quickly, continually, and consequentially. This means that the transfer of cybersecurity learning is crucial. We compared how different recognized “cognitive” transfer theories might help explain and synergize three aspects of cybersecurity education. These include teaching and training in diverse settings, assessing learning formatively & summatively, and testing & measuring achievement, proficiency, & readiness. We excluded newer sociocultural theories and their implications for inclusion as we explore those theories elsewhere. We first summarized the history of cybersecurity education and proficiency standards considering transfer theories. We then explored each theory and reviewed the most relevant cybersecurity education research; in some cases, we broadened our search to computing education. We concluded that (a) archaic differential transfer theories are still influential but have negative implications to be avoided, (b) constructionist theories are popular in K-12 settings but raise issues for assessment and transfer, (c) many embrace a general cognitive science perspective that can resolve tensions between modern cognitive-associationist and cognitive-constructivist theories that are popular with innovators, and (d) new perceptual and coordinative theories have potential worth exploring. These insights should support “generative” cybersecurity learning that transfers readily and widely to future classes, tests, and workplaces. These insights should be beneficial when designing and using cyber “ranges” and other hyper-realistic simulations, where transfer assumptions inform costly design decisions and undergird the validity of performance as evidence of proficiency

Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis

<p>Abstract</p> <p>Background</p> <p>The role of neuroinflammation in motor neuron death of amyotrophic lateral sclerosis (ALS) is unclear. The human mutant superoxide dismutase-1 (hmSOD1)-expressing murine transgenic model of ALS has provided some insight into changes in microglia activity during disease progression. The purpose of this study was to gain further knowledge by characterizing the immunological changes during disease progression in the spinal cord and peripheral nerve using the more recently developed hmSOD1 rat transgenic model of ALS.</p> <p>Methods</p> <p>Using immunohistochemistry, the extent and intensity of tissue CD11b expression in spinal cord, lumbar nerve roots, and sciatic nerve were evaluated in hmSOD1 rats that were pre-clinical, at clinical onset, and near disease end-stage. Changes in CD11b expression were compared to the detection of MHC class II and CD68 microglial activation markers in the ventral horn of the spinal cord, as well as to the changes in astrocytic GFAP expression.</p> <p>Results</p> <p>Our study reveals an accumulation of microglia/macrophages both in the spinal cord and peripheral nerve prior to clinical onset based on CD11b tissue expression. The microglia formed focal aggregates in the ventral horn and became more widespread as the disease progressed. Hypertrophic astrocytes were not prominent in the ventral horn until after clinical onset, and the enhancement of GFAP did not have a strong correlation to increased CD11b expression. Detection of MHC class II and CD68 expression was found in the ventral horn only after clinical onset. The macrophages in the ventral nerve root and sciatic nerve of hmSOD1 rats were observed encircling axons.</p> <p>Conclusions</p> <p>These findings describe for the first time in the hmSOD1 rat transgenic model of ALS that enhancement of microglia/macrophage activity occurs pre-clinically both in the peripheral nerve and in the spinal cord. CD11b expression is shown to be a superior indicator for early immunological changes compared to other microglia activation markers and astrogliosis. Furthermore, we suggest that the early activity of microglia/macrophages is involved in the early phase of motor neuron degeneration and propose that studies involving immunomodulation in hmSOD1transgenic models need to consider effects on macrophages in peripheral nerves as well as to microglia in the spinal cord.</p

Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system

<p>Abstract</p> <p>Background</p> <p>While it is clear that inbred strains of mice have variations in immunological responsiveness, the influence of genetic background following tissue damage in the central nervous system is not fully understood. A cortical explant system was employed as a model for injury to determine whether the immediate transcriptional response to tissue resection revealed differences among three mouse strains.</p> <p>Methods</p> <p>Immunological mRNAs were measured in cerebral cortex from SJL/J, C57BL/6J, and BALB/cJ mice using real time RT-PCR. Freshly isolated cortical tissue and cortical sections incubated in explant medium were examined. Levels of mRNA, normalized to β-actin, were compared using one way analysis of variance with pooled samples from each mouse strain.</p> <p>Results</p> <p>In freshly isolated cerebral cortex, transcript levels of many pro-inflammatory mediators were not significantly different among the strains or too low for comparison. Constitutive, baseline amounts of CD74 and antisecretory factor (ASF) mRNAs, however, were higher in SJL/J and C57BL/6J, respectively. When sections of cortical tissue were incubated in explant medium, increased message for a number of pro-inflammatory cytokines and chemokines occurred within five hours. Message for chemokines, IL-1α, and COX-2 transcripts were higher in C57BL/6J cortical explants relative to SJL/J and BALB/cJ. IL-1β, IL-12/23 p40, and TNF-α were lower in BALB/cJ explants relative to SJL/J and C57BL/6J. Similar to observations in freshly isolated cortex, CD74 mRNA remained higher in SJL/J explants. The ASF mRNA in SJL/J explants, however, was now lower than levels in both C57BL/6J and BALB/cJ explants.</p> <p>Conclusions</p> <p>The short-term cortical explant model employed in this study provides a basic approach to evaluate an early transcriptional response to neurological damage, and can identify expression differences in genes that are influenced by genetic background.</p

Solar variability indications from Nimbus 7 satellite data

The cavity pyrheliometer sensor of the Nimbus 7 Earth Radiation Experiment indicated low-level variability of the total solar irradiance. The variability appears to be inversely correlated with common solar activity indicators in an event sense. the limitations of the measuring system and available data sets are described

The Importance of extraction protocol on the analysis of novel waste sources of lignocellulosic biomass

peer-reviewedAs the utilization and consumption of lignocellulosic biomass increases, so too will the need for an adequate supply of feedstock. To meet these needs, novel waste feedstock materials will need to be utilized. Exploitation of these novel feedstocks will require information both on the effects of solvent extraction on the succeeding analysis of potential novel feedstocks and how accurate current methodologies are in determining the composition of novel lignocellulosic feedstocks, particularly the carbohydrate and lignin fractions. In this study, the effects of solvent extraction on novel feedstocks, including tree foliage, tree bark and spent mushroom compost, with 95% ethanol, water and both sequentially were examined. Chemical analyses were carried out to determine the moisture content, ash, extractives, post-hydrolysis sugars, Klason lignin (KL) and acid-soluble lignin (ASL) within the selected feedstocks. The result of extraction could be seen most strongly for Klason lignin, with a strong association between higher levels of Klason lignin levels and greater amounts of non-removed extractives (tree foliage and bark). Higher Klason lignin levels are reported to be due the condensation of non-removed extractives during hydrolysis, hence the lower Klason lignin determinations following extraction are more exact. In addition, total sugar determinations were lower following extractions. This is because of the solubility of non-cell-wall carbohydrates; thus, the determinations following extraction are more accurate representations of structural cell-wall polysaccharides such as cellulose. Such determinations will assist in determining the best way to utilize novel feedstocks such as those analyzed in this work

Calibrating Type Ia Supernovae using the Planetary Nebula Luminosity Function I. Initial Results

We report the results of an [O III] lambda 5007 survey for planetary nebulae (PN) in five galaxies that were hosts of well-observed Type Ia supernovae: NGC 524, NGC 1316, NGC 1380, NGC 1448 and NGC 4526. The goals of this survey are to better quantify the zero-point of the maximum magnitude versus decline rate relation for supernovae Type Ia and to validate the insensitivity of Type Ia luminosity to parent stellar population using the host galaxy Hubble type as a surrogate. We detected a total of 45 planetary nebulae candidates in NGC 1316, 44 candidates in NGC 1380, and 94 candidates in NGC 4526. From these data, and the empirical planetary nebula luminosity function (PNLF), we derive distances of 17.9 +0.8/-0.9 Mpc, 16.1 +0.8/-1.1 Mpc, and 13.6 +1.3/-1.2 Mpc respectively. Our derived distance to NGC 4526 has a lower precision due to the likely presence of Virgo intracluster planetary nebulae in the foreground of this galaxy. In NGC 524 and NGC 1448 we detected no planetary nebulae candidates down to the limiting magnitudes of our observations. We present a formalism for setting realistic distance limits in these two cases, and derive robust lower limits of 20.9 Mpc and 15.8 Mpc, respectively. After combining these results with other distances from the PNLF, Cepheid, and Surface Brightness Fluctuations distance indicators, we calibrate the optical and near-infrared relations for supernovae Type Ia and we find that the Hubble constants derived from each of the three methods are broadly consistent, implying that the properties of supernovae Type Ia do not vary drastically as a function of stellar population. We determine a preliminary Hubble constant of H_0 = 77 +/- 3 (random) +/- 5 (systematic) km/s/Mpc for the PNLF, though more nearby galaxies with high-quality observations are clearly needed.Comment: 25 pages, 12 figures. Accepted for publication by the Astrophysical Journal. Figures degraded to comply with limit. Full paper is available at: http://www.as.ysu.edu/~jjfeldme/pnlf_Ia.pd

Significance of the pericardium in human subjects: Effects on left ventricular volume, pressure and ejection

To assess the effect of the pericardium, left ventricular systolic function and diastolic compliance were studied in 15 patients before and after pericardiotomy during coronary artery surgery. Using first pass radionuclide angiography, curves for left ventricular systolic function (stroke work versus end-diastolic volume) and a measure of diastolic compliance (pulmonary capillary wedge pressure versus end-diastolic volume) were generated by changing body position to alter venous return. Left ventricular end-diastolic volume ranged from 41 to 111 ml/m2and pulmonary capillary wedge pressure from 0 to 24 mm Hg.No significant changes were found in blood pressure (150/83 to 148/82 mm Hg), heart rate (66.7 to 67.1 beats/min), cardiac index (2.38 to 2.41 liters/min per m2), ejection fraction (0.56 to 0.54), end-systolic volume index (31.4 to 32.2 ml/m2), end-diastolic volume index (65.9 to 69.5 ml/m2) or pulmonary capillary wedge pressure (7.5 to 7.3 mm Hg). The pericardium did not affect the curves relating stroke work and end-diastolic volume or those relating pulmonary capillary wedge pressure and end-diastolic volume. Thus, when filling pressure and volume are normal or only moderately elevated, the pericardium does not appear to affect left ventricular systolic function or diastolic compliance in patients

Numerical and statistical evidence for long-range ducted gravity wave propagation over Halley, Antarctica

Abundant short‒period, small‒scale gravity waves have been identified in the mesosphere and lower thermosphere over Halley, Antarctica, via ground‒based airglow image data. Although many are observed as freely propagating at the heights of the airglow layers, new results under modeled conditions reveal that a significant fraction of these waves may be subject to reflections at altitudes above and below. The waves may at times be trapped within broad thermal ducts, spanning from the tropopause or stratopause to the base of the thermosphere (∼140 km), which may facilitate long‒range propagation (∼1000s of km) under favorable wind conditions

MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men

The role of mitochondrial ROS in signalling muscle adaptations to exercise training has not been explored in detail. We investigated the effect of supplementation with the mitochondria-targeted antioxidant MitoQ on a) the skeletal muscle mitochondrial and antioxidant gene transcriptional response to acute high-intensity exercise and b) skeletal muscle mitochondrial content and function following exercise training. In a randomised, double-blind, placebo-controlled, parallel design study, 23 untrained men (age: 44 ± 7 years, VO2peak: 39.6 ± 7.9 ml/kg/min) were randomised to receive either MitoQ (20 mg/d) or a placebo for 10 days before completing a bout of high-intensity interval exercise (cycle ergometer, 10 × 60 s at VO2peak workload with 75 s rest). Blood samples and vastus lateralis muscle biopsies were collected before exercise and immediately and 3 h after exercise. Participants then completed high-intensity interval training (HIIT; 3 sessions per week for 3 weeks) and another blood sample and muscle biopsy were collected. There was no effect of acute exercise or MitoQ on systemic (plasma protein carbonyls and reduced glutathione) or skeletal muscle (mtDNA damage and 4-HNE) oxidative stress biomarkers. Acute exercise-induced increases in skeletal muscle peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α) mRNA expression were augmented in the MitoQ group. Despite this, training-induced increases in skeletal muscle mitochondrial content were similar between groups. HIIT-induced increases in VO2peak and 20 km time trial performance were also similar between groups while training-induced increases in peak power achieved during the VO2peak test were augmented in the MitoQ group. These data suggest that training-induced increases in peak power are enhanced following MitoQ supplementation, which may be related to the augmentation of skeletal muscle PGC1α expression following acute exercise. However, these effects do not appear to be related to an effect of MitoQ supplementation on exercise-induced oxidative stress or training-induced mitochondrial biogenesis in skeletal muscle