THE PHYSIOLOGICAL DISPOSITION OF THE URICOSURIC- SALURETIC AGENT (6,7-DICHLORO-2-METHYL-1 -OXO-2- PHENYL-5-INDANYLOXY)ACETIC ACID (MK-196) IN THE RAT, DOG, AND MONKEY

ABSTRACT The physiological disposition of a new aluretic-uricosuric agent. (6.7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)acetic acid . was studied in the rat. dog. and monkey. MK-196 was well absorbed and showed minimal metabolism in these species. Peak plasma levels of radioactivity and drug occurred 0.5-2 hr after oral administration at a dose of 2.5 mg/kg