55 research outputs found
Double proximity effect in hybrid planar Superconductor-(Normal metal/Ferromagnet)-Superconductor structures
We have investigated the differential resistance of hybrid planar
Al-(Cu/Fe)-Al submicron bridges at low temperatures and in weak magnetic
fields. The structure consists of Cu/Fe-bilayer forming a bridge between two
superconducting Al-electrodes. In superconducting state of Al-electrodes, we
have observed a double-peak peculiarity in differential resistance of the
S-(N/F)-S structures at a bias voltage corresponding to the minigap. We claim
that this effect (the doubling of the minigap) is due to an electron spin
polarization in the normal metal which is induced by the ferromagnet. We have
demonstrated that the double-peak peculiarity is converted to a single peak at
a coercive applied field corresponding to zero magnetization of the Fe-layer
Comparison of the effects of liraglutide and sibutramine in obese patients
Background: Obesity is a global noncommunicable pandemic. The low effectiveness of treating obesity is associated with the difficulty of maintaining weight loss due to the reaction of the appetite regulation system. Drugs with central mechanisms of action can help overcome this problem.Aim: The aim of our study was to compare the effects of liraglutide and sibutramine (Reduxin) on the dynamics of weight and cardiometabolic parameters in obese patients without cardiovascular diseases.Materials and methods: We estimated the dynamics of the main metabolic parameters (BMI, glucose, lipid metabolism, blood pressure), the level of hormones involved in the regulation of fat metabolism (leptin, adiponectin, insulin), the HOMA-IR index, markers of oxidative stress and inflammation during therapy with liraglutide in comparison with reduxin for 6 months in obese patients.Results: 64 obese patients were included in the study: 25 patients — in the “Liraglutide” group, 39 patients — in the “Sibutramine” group in accordance with the declared inclusion / exclusion criteria. The included patients were young, average body mass index (BMI) (37.92 ± 5.45 kg / m2), average glycemic level was 5.47 ± 0.81 mmol /l, HOMA-IR was 6.01 ± 4.25, blood pressure was at inclusion was within the normal range, but 21.8% of patients received antihypertensive therapy.Both treatment options provided a comparable decrease in body weight (-10.28% vs -9.47%, p = 0.13)., Leptin level (-32.12% vs -41.77%, p = 0.77) and myeloperoxidase (-33.33% vs -19.91%, p = 0.2). The blood pressure level did not change significantly on liraglutide, while on reduxin the level of diastolic blood pressure (dBP) increased significantly (6.87%, p = 0.006). There was a more pronounced decrease in insulin levels compared to the baseline level (-46%, p = 0.005), as well as a decrease in the HOMA-IR index (-50.08, p = 0.005) on liraglutide therapy.An increase in adiponectin levels (+ 45.36% vs 14.01%, p = 0.0045) and a decrease in low density lipoprotein(LDL) cholesterol were significantly more pronounced on reduxin therapy (-15.03% vs -9.4%, p = 0.006).36% of the participants completed their participation in the study ahead of schedule due to the lack of effect in the form of weight loss in the «Liraglutide» group. Side effects in the “Liraglutide” group were observed in 16% of patients. 48% of patients took part in the study within 6 months. In the «Sibutramine» group 33.4% of patients completed the study ahead of schedule for reasons unrelated to the drug intake, the side effects were observed in 20.5% of patients. 46.1% of participants in the «Sibutramine» group received therapy for 6 months.Conclusions: This study confirms the previous findings that both liraglutide and reduxin therapy provide effective weight loss. We found a positive trend in markers of inflammation, atherogenesis and oxidative stress, and leptin levels. Liraglutide therapy was accompanied by a more pronounced effect on the state of carbohydrate metabolism, and reduxin therapy provided a more pronounced dynamics of lipid disorders and adiponexin. Both groups were characterized by a rather low adherence to therapy, but the incidence of side effects requiring stopping therapy was higher in the Sibutramine group
Electrical conductivity and seebeck coefficient of hot-pressed specimens of aluminum borides and carboborides
Simulation of the processes of corrosion-mechanical wear of stainless steels in solutions of alkali and methods of increasing wear resistance
Planning of an experiment in the study of the extraction of scandium thiocyanate with chloroform solutions of 1,10-phenanthroline and collidine
Nonlocal supercurrent in mesoscopic multiterminal SNS Josephson junction in the low-temperature limit
Rupture of a uterus: last, real, future
In this article results research of women with ruptures of a uterus, the main reasons (a hem, the use of narcotic preparations, traumas, etc.), pathogenesis are considered. Legal bases of use of prostaglandins, Kristelera method. Algorithm of maintaining at suspicion of a rupture of a uterus
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