ASSESSMENT OF THE STATUS OF THE IMMUNE RESPONSE IN PREGNANT WOMEN WITH PLACENTAL INSUFFICIENCY TAKING INTO ACCOUNT THE SEVERITY OF CEREBRAL PATHOLOGY IN THEIR NEWBORN

Purpose. The study of immunological mechanisms of hypoxic-ischemic brain damage of varying severity in infants born to mothers with placental insufficiency.Materials and methods. A clinical and laboratory examination of 58 pregnant women with placental insufficiency in the period 38-39 weeks of pregnancy. The subjects were divided into subgroups: 1a - perinatal CNS lesions with an average degree of severity, clinically detectable at birth (n = 31), 1b - perinatal CNS damage with mild severity, clinically detectable at 1 month after birth (n = 27). The control group consisted of patients with physiological pregnancy and childbirth (n = 19).Results. It was revealed that the criterion of hypoxic-ischemic central nervous system in newborns is to increase the mother’s blood level of CD16 + NK-cell activation markers of T-cell CD69 +, CD25 +, apoptosis markers CD95 +, AnnexinV +, AnnexinV + PI +, shift the cytokine balance in favor of pro-inflammatory cytokines ( TNF-α, IL -6, IFN-γ), both in serum and amniotic fluid.Conclusions. The development of hypoxic-ischemic brain damage in newborn infants of mothers with placental insufficiency occurs against violations of the mechanisms of immune response