SuperLupus: A Deep, Long Duration Transit Survey

SuperLupus is a deep transit survey monitoring a Galactic Plane field in the Southern hemisphere. The project is building on the successful Lupus Survey, and will double the number of images of the field from 1700 to 3400, making it one of the longest duration deep transit surveys. The immediate motivation for this expansion is to search for longer period transiting planets (5-8 days) and smaller radii planets. It will also provide near complete recovery for the shorter period planets (1-3 days). In March, April, and May 2008 we obtained the new images and work is currently in progress reducing these new data.Comment: 3 pages, 2 figures, to appear in the Proceedings of IAU Symposium 253, 2008: Transiting Planet

Bone marrow transplantation alters the tremor phenotype in the murine model of globoid-cell leukodystrophy

Tremor is a prominent phenotype of the twitcher mouse, an authentic genetic model of Globoid-Cell Leukodystrophy (GLD, Krabbe’s disease). In the current study, the tremor was quantified using a force-plate actometer designed to accommodate low-weight mice. The actometer records the force oscillations caused by a mouse’s movements, and the rhythmic structure of the force variations can be revealed. Results showed that twitcher mice had significantly increased power across a broad band of higher frequencies compared to wildtype mice. Bone marrow transplantation (BMT), the only available therapy for GLD, worsened the tremor in the twitcher mice and induced a measureable alteration of movement phenotype in the wildtype mice. These data highlight the damaging effects of conditioning radiation and BMT in the neonatal period. The behavioral methodology used herein provides a quantitative approach for assessing the efficacy of potential therapeutic interventions for Krabbe’s disease

Lupus-TR-3b: A Low-Mass Transiting Hot Jupiter in the Galactic Plane?

We present a strong case for a transiting Hot Jupiter planet identified during a single-field transit survey towards the Lupus Galactic plane. The object, Lupus-TR-3b, transits a V=17.4 K1V host star every 3.91405d. Spectroscopy and stellar colors indicate a host star with effective temperature 5000 +/- 150K, with a stellar mass and radius of 0.87 +/- 0.04M_sun and 0.82 +/- 0.05R_sun, respectively. Limb-darkened transit fitting yields a companion radius of 0.89 +/- 0.07R_J and an orbital inclination of 88.3 +1.3/-0.8 deg. Magellan 6.5m MIKE radial velocity measurements reveal a 2.4 sigma K=114 +/- 25m/s sinusoidal variation in phase with the transit ephemeris. The resulting mass is 0.81 +/- 0.18M_J and density 1.4 +/- 0.4g/cm^3. Y-band PANIC image deconvolution reveal a V>=21 red neighbor 0.4'' away which, although highly unlikely, we cannot conclusively rule out as a blended binary with current data. However, blend simulations show that only the most unusual binary system can reproduce our observations. This object is very likely a planet, detected from a highly efficient observational strategy. Lupus-TR-3b constitutes the faintest ground-based detection to date, and one of the lowest mass Hot Jupiters known.Comment: 4 pages, 4 figures, accepted for publication in ApJ

Characterizing Bars at z~0 in the optical and NIR: Implications for the Evolution of Barred Disks with Redshift

Critical insights on galaxy evolution stem from the study of bars. With the advent of HST surveys that trace bars in the rest-frame optical out to z~1, it is critical to provide a reference baseline for bars at z~0 in the optical band. We present results on bars at z~0 in the optical and NIR bands based on 180 spirals from OSUBSGS. (1) The deprojected bar fraction at z~0 is ~60% +/-6% in the NIR H-band and ~44% +/-6% in the optical B-band. (2) The results before and after deprojection are similar, which is encouraging for high-redshift studies that forego deprojection. (3) Studies of bars at z~0.2-1.0 (lookback time of 3-8 Gyr) have reported an optical bar fraction of ~30% +/-6%, after applying cutoffs in absolute magnitude (M_V = 1.5 kpc), and bar ellipticity (e_bar >= 0.4). Applying these exact cutoffs to the OSUBSGS data yields a comparable optical B-band bar fraction at z~0 of ~ 34%+/-6%. This rules out scenarios where the optical bar fraction in bright disks declines strongly with redshift. (4) Most (~70%) bars have moderate to high strentgh or ellipticity (0.50 <= e_bar <= 0.75). There is no bimodality in the distribution of e_bar. The H-band bar fraction and e_bar show no substantial variation across RC3 Hubble types Sa to Scd. (5) RC3 bar types should be used with caution. Many galaxies with RC3 types "AB" turn out to be unbarred and RC3 bar classes "B" and "AB" have a significant overlap in e_bar. (6) Most bars have sizes below 5 kpc. Bar and disk sizes correlate, and most bars have a_bar/R_25~0.1-0.5. This suggests that the growths of bars and disks are intimately tied.Comment: 11 pages, 17 figures, 3 tables, ApJ accepted, abridged abstract below. Minor changes and shortened paper for ApJ limits. For high resolution figures see http://www.as.utexas.edu/~marinova/paper1-highres.pd

Limits on I-band microvariability of the Galactic Bulge Miras

We search for microvariability in a sample of 485 Mira variables with high quality I-band light curves from the second generation Optical Gravitational Lensing Experiment (OGLE-II). Rapid variations with amplitudes in the ~0.2-1.1 mag range lasting hours to days were discovered in Hipparcos data by de Laverny et al. (1998). Our search is primarily sensitive to events with time-scales of about 1 day, but retains a few percent efficiency (per object) for detecting unresolved microvariability events as short as 2 hours. We do not detect any candidate events. Assuming that the distribution of the event time profiles is identical to that from the Hipparcos light curves we derive the 95% confidence level upper limit of 0.038 per year per star for the rate of such events (1 per 26 years per average object of the ensemble). The high event rates of the order of 1 per year per star implied by the Hipparcos study in the H_P band are excluded with high confidence by the OGLE-II data in the I band. Our non-detection could still be explained by much redder spectral response of the I filter compared to the H_P band or by population differences between the bulge and the solar neighborhood. In any case, the OGLE-II I-band data provide the first limit on the rate of the postulated microvariability events in Mira stars and offer new quantitative constraints on their properties. Similar limits are obtained for other pulse shapes and a range of the assumed time-scales and size-frequency distributions.Comment: Accepted for publication in Ap

Behavioral Consequences of NMDA Antagonist-Induced Neuroapoptosis in the Infant Mouse Brain

Background: Exposure to NMDA glutamate antagonists during the brain growth spurt period causes widespread neuroapoptosis in the rodent brain. This period in rodents occurs during the first two weeks after birth, and corresponds to the third trimester of pregnancy and several years after birth in humans. The developing human brain may be exposed to NMDA antagonists through drug-abusing mothers or through anesthesia. Methodology/Principal Findings: We evaluated the long-term neurobehavioral effects of mice exposed to a single dose of the NMDA antagonist, phencyclidine (PCP), or saline, on postnatal day 2 (P2) or P7, or on both P2 and P7. PCP treatment on P2 + P7 caused more severe cognitive impairments than either single treatment. Histological examination of acute neuroapoptosis resulting from exposure to PCP indicated that the regional pattern of degeneration induced by PCP in P2 pups was different from that in P7 pups. The extent of damage when evaluated quantitatively on P7 was greater for pups previously treated on P2 compared to pups treated only on P7. Conclusions: These findings signify that PCP induces different patterns of neuroapoptosis depending on the developmental age at the time of exposure, and that exposure at two separate developmental ages causes more severe neuropathological and neurobehavioral consequences than a single treatment

Integral-field spectroscopy of the quadruple QSO HE 0435-1223: Evidence for microlensing

We present the first spatially resolved spectroscopic observations of the recently discovered quadruple QSO and gravitational lens HE0435-1223. Using the Potsdam Multi-Aperture Spectrophotometer (PMAS), we show that all four QSO components have very similar but not identical spectra. In particular, the spectral slopes of components A, B, and D are indistinguishable, implying that extinction due to dust plays no major role in the lensing galaxy. While also the emission line profiles are identical within the error bars, as expected from lensing, the equivalent widths show significant differences between components. Most likely, microlensing is responsible for this phenomenon. This is also consistent with the fact that component D, which shows the highest relative continuum level, has brightened by 0.07 mag since Dec 2001. We find that the emission line flux ratios between the components are in better agreement with simple lens models than broad band or continuum measurements, but that the discrepancies between model and data are still unacceptably large. Finally, we present a detection of the lensing galaxy, although this is close to the limits of the data. Comparing with a model galaxy spectrum, we obtain a redshift estimate of z_lens=0.44+-0.02.Comment: 9 pages, 7 figures, accepted for publication in A&

Expression of nampt in hippocampal and cortical excitatory neurons is critical for cognitive function

Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor or cosubstrate in many essential biological pathways. To date, the primary source of neuronal NAD(+) has been unclear. NAD(+) can be synthesized from several different precursors, among which nicotinamide is the substrate predominantly used in mammals. The rate-limiting step in the NAD(+) biosynthetic pathway from nicotinamide is performed by nicotinamide phosphoribosyltransferase (Nampt). Here, we tested the hypothesis that neurons use intracellular Nampt-mediated NAD(+) biosynthesis by generating and evaluating mice lacking Nampt in forebrain excitatory neurons (CaMKIIαNampt(−/−) mice). CaMKIIαNampt(−/−) mice showed hippocampal and cortical atrophy, astrogliosis, microgliosis, and abnormal CA1 dendritic morphology by 2–3 months of age. Importantly, these histological changes occurred with altered intrahippocampal connectivity and abnormal behavior; including hyperactivity, some defects in motor skills, memory impairment, and reduced anxiety, but in the absence of impaired sensory processes or long-term potentiation of the Schaffer collateral pathway. These results clearly demonstrate that forebrain excitatory neurons mainly use intracellular Nampt-mediated NAD(+) biosynthesis to mediate their survival and function. Studying this particular NAD(+) biosynthetic pathway in these neurons provides critical insight into their vulnerability to pathophysiological stimuli and the development of therapeutic and preventive interventions for their preservation

The Influence of Bars on Nuclear Activity

We test ideas on fueling of galactic nuclei by bar-driven inflow by comparing the detection rate and intensity of nuclear H II regions and AGNs among barred and unbarred galaxies in a sample of over 300 spirals selected from our recent optical spectroscopic survey of nearby galaxies. Among late-type spirals (Sc-Sm), but not early-type (S0/a-Sbc), we observe in the barred group a very marginal increase in the detection rate of H II nuclei and a corresponding decrease in the incidence of AGNs. The minor differences in the detection rates, however, are statistically insignificant, most likely stemming from selection effects and not from a genuine influence from the bar. The presence of a bar seems to have no noticeable impact on the likelihood of a galaxy to host either nuclear star formation or an AGN. The nuclei of early-type barred spirals do exhibit measurably higher star-formation rates than their unbarred counterparts, as indicated by either the luminosity or the equivalent width of H-alpha emission. By contrast, late-type spirals do not show such an effect. Bars have a negligible effect on the strength of the AGNs in our sample, regardless of the Hubble type of the host galaxy. This result confirms similar conclusions reached by other studies based on much smaller samples.Comment: To appear in the Astrophysical Journal. LaTex, 31 pages including 6 postscript figures and 3 tables. AAStex macros include

Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers

Infantile neuronal ceroid lipofuscinosis (INCL, Infantile Batten disease) is a neurodegenerative lysosomal storage disease caused by a deficiency in palmitoyl protein thioesterase-1 (PPT1). The PPT1-deficient mouse (Cln1−/−) is a useful phenocopy of human INCL. Cln1−/− mice display retinal dysfunction, seizures, motor deficits, and die at ~8 months of age. However, little is known about the cognitive and behavioral functions of Cln1−/− mice during disease progression. In the present study, younger (~1–2 months of age) Cln1−/− mice showed minor deficits in motor/sensorimotor functions while older (~5–6 months of age) Cln1−/− mice exhibited more severe impairments, including decreased locomotor activity, inferior cued water maze performance, decreased running wheel ability, and altered auditory cue conditioning. Unexpectedly, certain cognitive functions such as some learning and memory capabilities seemed intact in older Cln1−/− mice. Younger and older Cln1−/− mice presented with walking initiation defects, gait abnormalities, and slowed movements, which are analogous to some symptoms reported in INCL and parkinsonism. However, there was no evidence of alterations in dopaminergic markers in Cln1−/− mice. Results from this study demonstrate quantifiable changes in behavioral functions during progression of murine INCL and suggest that Parkinson-like motor/sensorimotor deficits in Cln1−/− mice are not mediated by dopamine deficiency