Dysfunction of Neuromuscular Synapses in the Genetic Model of Alzheimer’s Disease

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The function of synaptic transmission and presynaptic vesicular cycle in the neuromuscular synapses of the diaphragm was studied in transgenic APP/PS1 mice (Alzheimer’s disease model). The decrease in the quantal content of end-plate potential, intense depression of the amplitude of terminal plate potentials under conditions of lasting high frequency stimulation (50 Hz), a drastic prolongation of the synaptic vesicle recycling time in APP/PS1 mice in comparison with wild type mice were detected. Manifest dysfunction of the neuromuscular synapses, caused by disordered neurosecretion and recycling of the synaptic vesicles in the presynaptic nerve endings, was detected in the Alzheimer’s disease model on transgenic APP/PS1 mice. The study supplemented the notions on the pathogenesis of Alzheimer’s disease as a systemic disease, while the detected phenomena could just partially explain the development of motor disorders in this disease

On The Mobile Behavior of Solid 4^4He at High Temperatures

We report studies of solid helium contained inside a torsional oscillator, at temperatures between 1.07K and 1.87K. We grew single crystals inside the oscillator using commercially pure $^4$He and $^3$He-$^4$He mixtures containing 100 ppm $^3$He. Crystals were grown at constant temperature and pressure on the melting curve. At the end of the growth, the crystals were disordered, following which they partially decoupled from the oscillator. The fraction of the decoupled He mass was temperature and velocity dependent. Around 1K, the decoupled mass fraction for crystals grown from the mixture reached a limiting value of around 35%. In the case of crystals grown using commercially pure $^4$He at temperatures below 1.3K, this fraction was much smaller. This difference could possibly be associated with the roughening transition at the solid-liquid interface.Comment: 15 pages, 6 figure

Investigation of the Chaotic Dynamics of an Electron Beam with a Virtual Cathode in an External Magnetic Field

The effect of the strength of the focusing magnetic field on chaotic dynamic processes occurring inan electron beam with a virtual cathode, as well as on the processes whereby the structures form in the beamand interact with each other, is studied by means of two-dimensional numerical simulations based on solving a self-consistent set of Vlasov-Maxwell equations. It is shown that, as the focusing magnetic field is decreased,the dynamics of an electron beam with a virtual cathode becomes more complicated due to the formation andinteraction of spatio-temporal longitudinal and transverse structures in the interaction region of a vircator. The optimum efficiency of the interaction of an electron beam with the electromagnetic field of the vircator isachieved at a comparatively weak external magnetic field and is determined by the fundamentally two-dimensional nature of the motion of the beam electrons near the virtual cathode.Comment: 12 pages, 8 figure

Self-similar solution of a nonsteady problem of nonisothermal vapour condensation on a droplet growing in diffusion regime

This paper presents a mathematically exact self-similar solution to the joint nonsteady problems of vapour diffusion towards a droplet growing in a vapour-gas medium and of removal of heat released by a droplet into a vapour-gas medium during vapour condensation. An equation for the temperature of the droplet is obtained; and it is only at that temperature that the self-similar solution exists. This equation requires the constancy of the droplet temperature and even defines it unambiguously throughout the whole period of the droplet growth. In the case of strong display of heat effects, when the droplet growth rate decreases significantly, the equation for the temperature of the droplet is solved analytically. It is shown that the obtained temperature fully coincides with the one that settles in the droplet simultaneously with the settlement of its diffusion regime of growth. At the obtained temperature of the droplet the interrelated nonsteady vapour concentration and temperature profiles of the vapour-gas medium around the droplet are expressed in terms of initial (prior to the nucleation of the droplet) parameters of the vapour-gas medium. The same parameters are used to formulate the law in accordance with which the droplet is growing in diffusion regime, and also to define the time that passes after the nucleation of the droplet till the settlement of diffusion regime of droplet growth, when the squared radius of the droplet becomes proportionate to time. For the sake of completeness the case of weak display of heat effects is been studied.Comment: 12 pages, 4 figure

Test of exotic scalar and tensor interactions in K_e3 decay using stopped positive kaons

The form factors of the decay K+ --> pi0 e+ nu (K_e3) have been determined from the comparison of the experimental and Monte Carlo Dalitz distributions containing about 10^5 K_e3 events. The following values of the parameters were obtained: lambda_+ = 0.0278 +- 0.0017(stat) +- 0.0015(syst), f_S/f_+(0) = 0.0040 +- 0.0160(stat) +- 0.0067(syst) and f_T/f_+(0) = 0.019 +- 0.080(stat) +- 0.038(syst). Both scalar f_S and tensor f_T form factors are consistent with the Standard Model predictions of zero values.Comment: 10 pages, 5 figures, contributed to the proceedings of NANP Conference, Dubna, June 19-23, 200

ПЕРСИСТЕНТНОСТЬ МИКРОФИЛЯРИЦИДНОГО ДЕЙСТВИЯ АВЕРСЕКТА КОМБИ ПРИ ОНХОЦЕРКОЗЕ И СЕТАРИОЗЕ КРУПНОГО РОГАТОГО СКОТА

Persistent effect of aversect combi against microfilaria Onchocerca spp. and Setaria spp. is studied. The drug in therapeutic dose of 0,2 mg/kg showed persistence effect during 4–6 months.Изучена персистентность действия аверсекта комби против микрофилярий Onchocerca spp. и Setaria spp. Препарат в терапевтической дозе 0,2 мг/кг обладает персистентным в течение 4–6 месяцев действием против микрофилярий

Defects and glassy dynamics in solid He-4: Perspectives and current status

We review the anomalous behavior of solid He-4 at low temperatures with particular attention to the role of structural defects present in solid. The discussion centers around the possible role of two level systems and structural glassy components for inducing the observed anomalies. We propose that the origin of glassy behavior is due to the dynamics of defects like dislocations formed in He-4. Within the developed framework of glassy components in a solid, we give a summary of the results and predictions for the effects that cover the mechanical, thermodynamic, viscoelastic, and electro-elastic contributions of the glassy response of solid He-4. Our proposed glass model for solid He-4 has several implications: (1) The anomalous properties of He-4 can be accounted for by allowing defects to freeze out at lowest temperatures. The dynamics of solid He-4 is governed by glasslike (glassy) relaxation processes and the distribution of relaxation times varies significantly between different torsional oscillator, shear modulus, and dielectric function experiments. (2) Any defect freeze-out will be accompanied by thermodynamic signatures consistent with entropy contributions from defects. It follows that such entropy contribution is much smaller than the required superfluid fraction, yet it is sufficient to account for excess entropy at lowest temperatures. (3) We predict a Cole-Cole type relation between the real and imaginary part of the response functions for rotational and planar shear that is occurring due to the dynamics of defects. Similar results apply for other response functions. (4) Using the framework of glassy dynamics, we predict low-frequency yet to be measured electro-elastic features in defect rich He-4 crystals. These predictions allow one to directly test the ideas and very presence of glassy contributions in He-4.Comment: 33 pages, 13 figure

Epizootic Activity of Natural Plague Foci in the Territory of the Russian Federation in 2014 and Prognosis for 2015

. Isolated were 128 plague agent strains: from rodents and lagomorphs - 24, 103 - from bloodsucking arthropods. One strain was obtained from a patient in the territory of Gorno-Altaisk high-mountain natural plague focus. Substantiated has been epizootiological prognosis claiming persistent challenging epidemiological situation in the foci. Outlined is the necessity to use epizootiological forecasting as the basis for scheduling and carrying out epidemiological monitoring and preventive measures in active natural plague foci. Due to the varying epidemiological significance of Y. pestis ssp. pestis , Y. pestis ssp. caucasica , and Y. pestis ssp. altaica strains the data on their spatial distribution should be deployed for differentiation of focal areas according to the degree of the potential epidemic hazard

Epizootic Activity of Natural Plague Foci of the Russian Federation in 2015, and Prognosis for 2016

Objective of the study is to evaluate the state of parasitic systems and activity of natural plague foci of the Russian Federation in 2015 and to develop epizootiological forecast for 2016. In 2015, plague epizooties were detected in the territory of Gorno-Altaisk high-mountain, Tuva mountain, and Pre-Caspian sandy natural plague foci with a total area amounting to 1573.4 square kilometers. Isolated were 46 strains of plague microbe, including the isolates from rodents and leporines - 18, and from fleas - 28. Substantiated is epizootiological prognosis for sustaining challenging epidemiological situation in Gorno-Altaisk high-mountain and Tuva mountain natural foci in 2016. Demonstrated is the fact that consequently to effective prompt prophylactic measures (field deratization, disinsection) in 2015 decreased epizootic activity of Pre-Caspian sandy focus is observed. Specified is retention of low numbers of carriers and vectors of plague in natural foci of North and North-Western Caspian Sea Region, Pre-Caucasian, Caucasian, and Transbaikal Territories. Identified is upward trend for numbers of the little souslik in Pre-Caspian North-Western steppe, Volga-Ural steppe, Dagestan lowland-piedmont, and Pre-Caspian sandy natural plague foci