Testing of micronized praziquantel and albendazole dosage forms against bothriocephalosis of cyprinids

The purpose of the research is to develop and test new dosage forms against bothriocephalosis of cyprinids.Materials and methods. The study was performed in the experimental therapy laboratory of the VNIIP – FSC VIEV, and on a cage fish farm of Cherepetsky Rybkhoz JSC (Suvorov, Tula Region). A formulation was developed for two micronized dosage forms of albendazole and praziquantel to prevent and treat cestodosis in fish, namely, micronized albendazole and micronized praziquantel. For experiments to test micronized dosage forms of the drugs against bothriocephalosis of cyprinids, medicated feeds were developed using a special technology with added hot water and beet molasses. Each medicated feed contained 2% of the praziquantel- and albendazole-based dosage form. To determine the infection of the fish with cestodes, carp yearlings were studied at Cherepetsky Rybkhoz JSC. Clinical examination and pathoanatomical dissection of the fish were conducted selectively using a common method, after which the prevalence and intensity of the Bothriocephalus sp. infection were determined in fish. The medicated feed was given at the rate of 5% of fish weight in the trays, and put into the feeders installed at the bottom of the trays. The first group of fish received the medicated food with micronized albendazole, and the second, with micronized praziquantel. The doses were 25 and 30 mg/kg for the active substance, respectively. The effectiveness of experimental batches of the medicated feeds with praziquantel and albendazole dosage forms was recorded by results of the helminthological dissection of all experimental and control fish on day 4 of the therapeutic feeding.Results and discussion. Preliminary tests of the micronized albendazole and praziquantel dosage forms in the medicated feeds showed a 58.3% extense-effectiveness with a 61.9% intense-effectiveness, and a 75.0% extense-effectiveness with a 88.1% intense-effectiveness when applied once at a dose of 5% of fish weight (doses of 25 and 30 mg/kg for the AS, respectively)

On the Implementation of the Program «Digital Economy of the Russian Federation»

The digitalization of Russia is the task of the whole society, it is a matter of the national security of our country. Patriotism, information openness, creative thinking of Russians, widespread distribution of non-cash payments - this is the basis on which Russia will be able not only to catch up with world leaders, but also to take the lead in certain segments. On the basis of our study, we proposed a model for the interaction of subjects in the digital economy of Russia. The presented model reflects five levels of interaction of subjects: mego-, macro-, meso-, micro- and household level. The macro-level is represented by the main regulatory organizations that form the overall strategy of the country's economic development and the digital economy in particular. Meso-level has regional organizations that coordinate and direct the actions of economic entities in the Russian digital economy market. The micro-level covers the activities of Internet entrepreneurs and private investors, the level of households is represented by individuals and families as consumers of goods and services

Prospects for the Development of the Educational Comics

В статье описано влияние образовательного комикса на усвоение учебного материала. Проведен обзор исторических сведений о возникновении, применении и влиянии образовательного комикса в образовательной среде. Рассмотрена взаимосвязь образовательного комикса и концепции «эдьютейнмент». Дан перечень элементов графического дизайна, влияющих на построение и восприятие образовательного комикса. Подчеркнута важность привлечения различных специалистов для развития и повышения научного соответствия образовательного комикса.The article describes the influence of educational comics on the assimilation of educational material. The review of historical information about the origin, application and influence of educational comics in the educational environment is carried out. The relationship between educational comics and the concept of «edutainment» is considered. A list of graphic design elements influencing the construction and perception of educational comics is given. The importance of attracting various specialists to develop and improve the scientific relevance of educational comics is emphasized

On a Set of Economic Support Measures for Companies Whose Products Have the Status of Telecommunication Equipment of Russian Origin

Economic support measures, including concessional lending to buyers of such products and reduction of customs duties on components not produced in the territory of the Russian Federation, should stimulate the development of the market for the consumption of domestic Telecom equipment in Russia. The digital transformation of Russia it is a matter of national security of country. Support of national culture, a single information and statistical industry center, reduction of retirement age and equipment with video cameras of children’s institutions, the movement of volunteers and the mechanism of “on-site inspections” of buyers of Telecom equipment market — is the basis of support for companies whose products have the status of telecommunications equipment of Russian origin

National Peculiarities of Business in the Market of Mobile Commerce of Russia

Small mobile commerce businesses, due to their flexibility and mobility, are able to adapt to the changing environmental conditions and form new lines of business in accordance with the challenges of the time. Mobile commerce is a continuation of e-commerce, the translation of e-commerce into mobile forms. Forms of realization of the essence of mobile commerce are diverse. Mobile commerce allows people to transfer the entire information flow to users’ mobile phones, giving users complete freedom of movement. The article describes the objects and carried out the classification of the subjects of mobile commerce. National peculiarities of entrepreneurship in the Russian mobile commerce market are revealed

Practical Experience of Managing the Distributed E-Learning System «SPIDER» in the Preparation of Students of the Faculty of Economics and Finance at the North-West Institute of Management, Branch of RANEPA

We consider examines the place and role of E-learning in the Internet economy, the nature and features of the distributed system of E-learning, the practical experience of the managing of distributed E-learning system on the example of DELS “SPIDER”. This system is used in the preparation of students of the faculty of Economics and Finance at the North-West Institute of Management, branch of RANEPA. In the article the analysis of the impact of the Internet on learning, history of development of E-learning, the most important elements of the conceptual apparatus of E-learning, the essence of distributed E-learning system “SPIDER”. We identify a number of constraining factors for its implementation in the educational process. We identify a number of constraining factors for implementation in the educational process The method of teaching students with the use of modern Internet technologies based on DELS “SPIDER” :The authors formulated four principles of E-Learning: personal approach, calm study temp, favorable psychological climate, modern material and technical base in the institute and relax room for the teachers

The efficacy of combined micronized Niclosamideand Albendazole-based dosage forms against bothriocephalosis of cyprinids

The purpose of the research is to develop and test new combined dosage forms against bothriocephalosis of cyprinids in the cage culture fishery.Materials and methods. Combined micronized Niclosamide- and Albendazole-based dosage forms were developed; labscale batches of dosage forms of drugs and medicated feeds were developed with these drug forms; Bothriocephalus sp. infection rate in fish was determined during the growing period; and preliminary test effectiveness was confirmed for combined micronized niclosamide- and albendazole-based dosage forms against bothriocephalosis in cyprinids in the incubation shop of a cage culture fishery according to standard practices. The efficacy was assessed for combined micronized niclosamide- and albendazole-based dosage forms.Results and discussion. The preliminary tests of combined micronized Albendazole- and Niclosamide-based dosage forms as part of medicated feeds showed 100% extense-effectiveness with 100% intense-effectiveness, and 60% extenseeffectiveness with 77.8% intense-effectiveness when administered once at a dose of 5% of the fish weight (doses for the active substance of 50 and 40 mg/kg, respectively)

GR 290 (Romano's Star): 2. Light history and evolutionary state

We have built the historical light curve of the luminous variable GR 290 back to 1901, from old observations of the star found in several archival plates of M 33. These old recordings together with published and new data show that for at least half a century the star was in a low luminosity state, with B ~18. After 1960, five large variability cycles of visual luminosity were recorded. The amplitude of the oscillations was seen increasing towards the 1992-1994 maximum, then decreasing during the last maxima. The recent light curve indicates that the photometric variations have been quite similar in all the bands, and that the B-V color index has been constant within +/-0.1 m despite the 1.5m change of the visual luminosity. The spectrum of GR 290 at the large maximum of 1992-94, was equivalent to late-B type, while, during 2002-2014, it has varied between WN10h-11h near the visual maxima to WN8h-9h at the luminosity minima. We have detected, during this same period, a clear anti-correlation between the visual luminosity, the strength of the HeII 4686 A emission line, the strength of the 4600-4700 A lines blend and the spectral type. From a model analysis of the spectra collected during the whole 2002-2014 period we find that the Rosseland radius R_{2/3}, changed between the minimum and maximum luminosity phases by a factor of 3, while T_eff varied between about 33,000 K and 23,000 K. The bolometric luminosity of the star was not constant, but increased by a factor of ~1.5 between minimum and maximum luminosity, in phase with the apparent luminosity variations. In the light of current evolutionary models of very massive stars, we find that GR 290 has evolved from a ~60 M_Sun progenitor star and should have an age of about 4 million years. We argue that it has left the LBV stage and is moving to a Wolf-Rayet stage of late nitrogen spectral type.Comment: Accepted on The Astronomical Journal, 10 figures. Replaced because the previous uploaded file was that without the final small corrections requested by the refere

TEACHING MODELS OF RUSSIAN LANGUAGE FOR BILINGUAL LEARNERS IN RUSSIAN AND FOREIGN EDUCATION SYSTEMS

The article considers the implementation of different methods of learning and teaching Russian for bilingual learners in educational systems in Russia, former soviet countries and far abroad countries (EU, USA, Canada). Pragmatic goals of different categories of learners which are based on satisfaction in personal communicative needs and educational status of Russian determine content of teaching

Influence of polymer modification of complex fertilizer on the efficiency of phosphorus and potassium use by winter wheat on the southern chernozem

In modern conditions of unprecedented challenges, an alternative to the technological degradation of fertilizer application systems can be the development of original forms of long-acting fertilizers. Despite significant progress in the adaptation of progressive systems of agrochemical impacts, the use of traditional forms of mineral fertilizers does not allow using the full potential of the introduced nutrients, since the processes of incomplete denitrification, immobilization and leaching (leaching) of the main macronutrients (NPK), along with the action of urease, lead to unproductive loss of nutrients in the soil. In addition to economic losses, there are negative environmental consequences – eutrophication of water bodies, emission of greenhouse gases. The studies were carried out in 2022 under production conditions in the Kursk district of the Stavropol Territory on the farm of “StavAgroCom” on southern carbonate chernozem. As a modifier of mineral fertilizers, one of the most common synthetic polymers, polyvinyl alcohol (PVA), was used. The polymer consumption rate was 3, 5 and 7 kg per 1 ton of fertilizer. Yield growth was positively correlated with the dose of polymer in the fertilizer. The analysis of soil properties was carried out by the method of principal components. The resulting clustering in the coordinates of the first two components (in total they explain 65% of the data variation) shows significant differences in soil properties under different experimental options. To assess the efficiency of the use of nutrients depending on the dose of the polymer, a differential indicator was proposed – the additional efficiency of the use of nutrients (E). It was estimated from the increase in yield relative to the zero dose of the polymer per unit reduction in the concentration of this element in the soil according to the proposed formula. It is shown that the polymer use in fertilizer gives a statistically significant increase in the efficiency of phosphorus and potassium use by winter wheat