Shake-off of loosely bound electrons in Auger decays of Kr 2p core hole states

Multicharged Kr ions have been measured using monochromatized undulator radiation combined with a coincidence technique. It has been found that a charge-state distribution of Kr ions being coincident with satellite peaks of Kr 2p3/2 photoelectron is slightly different from that for the main line. Resonant Auger peaks for 2p–1nl-->1G4 nl transitions generated essentially Kr4+ only, which differs from the charge-state distribution for the normal Auger peak. These findings suggest that loosely bound electrons in high Rydberg orbitals are easily shaken-off in electron emission processes.Erratum is added on the last page

Vibrational effect on the fragmentation dynamics of the C K-shell excited CF2CH2

Photoabsorption cross-sections of CF2CH2 were measured in the carbon K-edge region and linear time-of-flight mass spectra were acquired at some photon energies across the two π* peaks. The kinetic energy distributions of CH2+ and CF2+ with two components were deduced from the analysis of the mass spectra. The CH2+ ion with high kinetic energies increases with the extent of vibrational excitation of the CF 1s-1π* state, indicating that molecular vibrations play an important role in the photofragmentation of the inner-shell excited molecule

Docetaxel for non small cell lung cancer harboring the activated EGFR mutation with T790M at initial presentation

Hiromichi Yamane,1 Nobuaki Ochi,1 Masayuki Yasugi,2 Takayuki Tabayashi,1 Tomoko Yamagishi,1 Yasumasa Monobe,3 Akiko Hisamoto,4 Katsuyuki Kiura,4 Nagio Takigawa1 1Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan; 2Department of Respiratory Medicine, National Hospital Organization Fukuyama Medical Center, Fukuyama, Japan; 3Department of Pathology, Kawasaki Medical School Kawasaki Hospital, Okayama, Japan; 4Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Okayama, Japan Abstract: A 72-year-old woman was referred to our hospital with Stage IV non-small-cell lung cancer (NSCLC). Chest computed tomography revealed a mass in the upper lobe of the right lung, with pleural effusion. Cytologic examination identified adenocarcinoma cells in the right pleural effusion. Furthermore, both a deletion mutation in exon 19 and a threonine–methionine substitution mutation at position 790 in exon 20 (T790M) were detected in the epidermal growth factor receptors (EGFR) in the malignant cells. As systemic chemotherapy consisting of carboplatin and pemetrexed or erlotinib proved ineffective, docetaxel monotherapy was initiated as a third-line treatment. Following salvage chemotherapy, her Eastern Cooperative Oncology Group performance status improved from 3 to 1, with tumor regression over 5 months. To the best of our knowledge, this is the first report of successful docetaxel treatment for a patient with NSCLC harboring the T790M EGFR-activating mutation identified before treatment with EGFR tyrosine kinase inhibitors. Keywords: non-small-cell lung cancer, EGFR mutation, pretreatment mutation, T790M, docetaxe

SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F

10.1111/bjh.12327British Journal of Haematology1616811-820BJHE

Hydrogen bonding in methanol clusters probed by inner-shell photoabsorption spectroscopy in the carbon and oxygen K-edge regions

Hydrogen bonding in methanol clusters has been investigated by using inner-shell photoabsorption spectroscopy and density functional theory (DFT) calculations in the carbon and oxygen K-edge regions. The partial-ion-yield (PIY) curves of H(CH3OH)n+ were measured as the soft X-ray absorption spectra of methanol clusters. The first resonance peak in the PIY curves, which is assigned to the σ*(O–H) resonance transition, exhibits a 1.20-eV blue-shift relative to the total-ion-yield (TIY) curves of molecular methanol in the oxygen K-edge region, while it exhibits a shift of only 0.25 eV in the carbon K-edge region. Decreased intensities of the transitions to higher Rydberg orbitals were observed in the PIY curves of the clusters. The drastic change in the σ*(O–H) resonance transition is interpreted by the change in the character of the σ*(O–H) molecular orbital at the H-donating OH site due to the hydrogen-bonding (HB) interaction