CTF3: Design of Driving Beam Combiner Ring

In CTF3 the beam compression of the driving beam structure between the main linac and the decelerating section is obtained with a delay loop and a combiner ring which increase the pulse current by a factor 10. The design of the combiner ring is presented. Tunable isochronicity condition, corrected up to second order, should assure preservation of the correlation in the longitudinal phase space during the compression. Path-length tuning devices are included in the combiner ring layout to compensate for orbit variations

Proposal for taking data with the KLOE-2 detector at the DAΦ\PhiNE collider upgraded in energy

This document reviews the physics program of the KLOE-2 detector at DA$\Phi$NE upgraded in energy and provides a simple solution to run the collider above the $\phi$-peak (up to 2, possibly 2.5 GeV). It is shown how a precise measurement of the multihadronic cross section in the energy region up to 2 (possibly 2.5) GeV would have a major impact on the tests of the Standard Model through a precise determination of the anomalous magnetic moment of the muon and the effective fine-structure constant at the $M_Z$ scale. With a luminosity of about $10^{32}$cm$^{-2}$s$^{-1}$, DA$\Phi$NE upgraded in energy can perform a scan in the region from 1 to 2.5 GeV in one year by collecting an integrated luminosity of 20 pb$^{-1}$ (corresponding to a few days of data taking) for single point, assuming an energy step of 25 MeV. A few years of data taking in this region would provide important tests of QCD and effective theories by $\gamma\gamma$ physics with open thresholds for pseudo-scalar (like the $\eta'$), scalar ($f_0,f'_0$, etc...) and axial-vector ($a_1$, etc...) mesons; vector-mesons spectroscopy and baryon form factors; tests of CVC and searches for exotics. In the final part of the document a technical solution for the energy upgrade of DA$\Phi$NE is proposed.Comment: 19 pages, 8 figure

DaΦ{\Phi}ne developments for the KLOE-2 experimental run

Recently the peak luminosity achieved on the DA{\Phi}NE collider has been improved by almost a factor three by implementing a novel collision scheme based on large Piwinski angle and Crab-Waist. This encouraging result opened new perspectives for physics research and a new run with the KLOE-2 detector has been scheduled to start by spring 2010. The KLOE-2 installation is a complex operation requiring a careful design effort and a several months long shutdown. The high luminosity interaction region has been deeply revised in order to take into account the effect on the beam caused by the solenoidal field of the experimental detector and to ensure background rejection. The shutdown has been also used to implement several other modifications aimed at improving beam dynamics: the wiggler poles have been displaced from the magnet axis in order to cancel high order terms in the field, the feedback systems have been equipped with stronger power supplies and more efficient kickers and electrodes have been inserted inside the wiggler and the dipole vacuum chambers, in the positron ring, to avoid the e-cloud formation. A low level RF feedback has been added to the cavity control in both rings.Comment: 3 pages, 3 figures, presented to the IPAC10 conferenc

Experience with DAΦNE Upgrade Including Crab Waist

International audienceIn 2007 DAΦNE was upgraded to operate in a regime of large Piwinski angle, with a novel IR optics, reduced vertical beta at the interaction point, and additional sextupoles providing for crab waist collisions. The specific luminosity was boosted by more than a factor of four, and the peak luminosity was more than doubled with respect to the maximum value obtained with the original collider configuration. The DAΦNE commissioning as well as the first experience with large Piwinski angle and crab waist collisions scheme will be reported

Technical Design Report EuroGammaS proposal for the ELI-NP Gamma beam System

The machine described in this document is an advanced Source of up to 20 MeV Gamma Rays based on Compton back-scattering, i.e. collision of an intense high power laser beam and a high brightness electron beam with maximum kinetic energy of about 720 MeV. Fully equipped with collimation and characterization systems, in order to generate, form and fully measure the physical characteristics of the produced Gamma Ray beam. The quality, i.e. phase space density, of the two colliding beams will be such that the emitted Gamma ray beam is characterized by energy tunability, spectral density, bandwidth, polarization, divergence and brilliance compatible with the requested performances of the ELI-NP user facility, to be built in Romania as the Nuclear Physics oriented Pillar of the European Extreme Light Infrastructure. This document illustrates the Technical Design finally produced by the EuroGammaS Collaboration, after a thorough investigation of the machine expected performances within the constraints imposed by the ELI-NP tender for the Gamma Beam System (ELI-NP-GBS), in terms of available budget, deadlines for machine completion and performance achievement, compatibility with lay-out and characteristics of the planned civil engineering

Chronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile rat brain

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linkMethylphenidate (MPH) is the front-line psychostimulant medication prescribed for alleviating the symptoms associated with attention deficit hyperactivity disorder (ADHD) in children. Here, we investigated the effects of chronic MPH (2.0 mg/kg, twice daily for 15 days) exposure to young rats (20-25 days old at start of treatment) on the expression of genes and proteins associated with neuroplasticity, such as activity regulated cytoskeleton-associated protein (Arc), insulin receptor substrate protein 53 (IRSp53), cell division control protein 42 (Cdc42), and actin-related protein 2 (Arp2). Chronic MPH increased Arc expression in areas of the cerebrum including, the striatum, nucleus accumbens and hippocampus. In addition, chronic MPH also increased the expression of IRSp53 in the striatum, while Cdc42 and Arp2 were specifically increased in the nucleus accumbens. Conversely, chronic MPH decreased Arc and IRSp53 protein expression in the cerebellum, indicating differential effects of the drug in cerebral areas relative to the cerebellum. Overall, our results indicate that chronic MPH treatment increases expression of genes and proteins associated with dendritic spine formation and neuronal plasticity in target areas of the cerebrum while it decreases the expression in the cerebellum