Geochemical characterisation of northern Norwegian fjord surface sediments: a baseline for further paleo-environmental investigations

Norwegian fjord sediments are promising archives for very high resolution records of past environmental changes. Recent investigations of the modern depositional environment within fjords revealed that the accurate quantification of the inputs, sources, and sedimentary preservation of organic and inorganic material is crucial to decipher long term past climate signals in the sedimentary record of a certain fjord. Here, we investigate the elemental composition, bulk mineral assemblage and grain size distribution of forty-one surface sediment samples from a northern Norwegian fjord system. We reveal modern geochemical and sedimentological processes that occur within the Vestfjord, Ofotfjord and Tysfjord. Our results indicate a very heterogeneous sediment supply and intricate sedimentation processes. We propose that this is related to the complex fjord bathymetry, a low hydrodynamic energy environment, differences in the hinterland bedrock composition and a relatively small drainage area causing a rather diffuse freshwater inflow. Moreover, we show that marine carbonate productivity is the main calcite and Ca source in all three fjords

Episodic and long-lasting Paleozoic felsic magmatism in the pre-Alpine basement of the Suretta nappe (eastern Swiss Alps)

The Suretta nappe of eastern Switzerland contains a series of meta-igneous rocks, with the Rofna Porphyry Complex (RPC) being the most prominent member. We present LA-ICP-MS U-Pb zircon data from 12 samples representing a broad spectrum of meta-igneous rocks within the Suretta nappe, in order to unravel the pre-Alpine magmatic history of this basement unit. Fine-grained porphyries and coarse-grained augengneisses from the RPC give crystallization ages between 284 and 271Ma, which either represent distinct magma pulses or long-lasting magmatic activity in a complex magma chamber. There is also evidence for an earlier Variscan magmatic event at ~320-310Ma. Mylonites at the base of the Suretta nappe are probably derived from either the RPC augengneisses or another unknown Carboniferous-Permian magmatic protolith with a crystallization age between 320 and 290Ma. Two polymetamorphic orthogneisses from the southern Suretta nappe yield crystallization ages of ~490Ma. Inherited zircon cores are mainly of late Neoproterozoic age, with minor Neo- to Paleoproterozoic sources. We interpret the Suretta nappe as mainly representing a Gondwana-derived crustal unit, which was subsequently intruded by minor Cambrian-Ordovician and major Carboniferous-Permian magmatic rocks. Finally, the Suretta nappe was thrust into its present position during the Alpine orogeny, which hardly affected the U-Pb system in zirco

Heart Rate during Conflicts Predicts Post-Conflict Stress-Related Behavior in Greylag Geese

Background: Social stressors are known to be among the most potent stressors in group-living animals. This is not only manifested in individual physiology (heart rate, glucocorticoids), but also in how individuals behave directly after a conflict. Certain ‘stress-related behaviors ’ such as autopreening, body shaking, scratching and vigilance have been suggested to indicate an individual’s emotional state. Such behaviors may also alleviate stress, but the behavioral context and physiological basis of those behaviors is still poorly understood. Methodology/Principal Findings: We recorded beat-to-beat heart rates (HR) of 22 greylag geese in response to agonistic encounters using fully implanted sensor-transmitter packages. Additionally, for 143 major events we analyzed the behavior shown by our focal animals in the first two minutes after an interaction. Our results show that the HR during encounters and characteristics of the interaction predicted the frequency and duration of behaviors shown after a conflict. Conclusions/Significance: To our knowledge this is the first study to quantify the physiological and behavioral responses to single agonistic encounters and to link this to post conflict behavior. Our results demonstrate that ‘stress-related behaviors’ are flexibly modulated by the characteristics of the preceding aggressive interaction and reflect the individual’s emotional strain, which is linked to autonomic arousal. We found no support for the stress-alleviating hypothesis, but we propose tha

The potential of open-access data for flood estimations: uncovering inundation hotspots in Ho Chi Minh City, Vietnam, through a normalized flood severity index

Hydro-numerical models are increasingly important to determine the adequacy and evaluate the effectiveness of potential flood protection measures. However, a significant obstacle in setting up hydro-numerical and associated flood damage models is the tedious and oftentimes prohibitively costly process of acquiring reliable input data, which particularly applies to coastal megacities in developing countries and emerging economies. To help alleviate this problem, this paper explores the usability and reliability of flood models built on open-access data in regions where highly resolved (geo)data are either unavailable or difficult to access yet where knowledge about elements at risk is crucial for mitigation planning. The example of Ho Chi Minh City, Vietnam, is taken to describe a comprehensive but generic methodology for obtaining, processing and applying the required open-access data. The overarching goal of this study is to produce preliminary flood hazard maps that provide first insights into potential flooding hotspots demanding closer attention in subsequent, more detailed risk analyses. As a key novelty, a normalized flood severity index (INFS), which combines flood depth and duration, is proposed to deliver key information in a preliminary flood hazard assessment. This index serves as an indicator that further narrows down the focus to areas where flood hazard is significant. Our approach is validated by a comparison with more than 300 flood samples locally observed during three heavy-rain events in 2010 and 2012 which correspond to INFS-based inundation hotspots in over 73 % of all cases. These findings corroborate the high potential of open-access data in hydro-numerical modeling and the robustness of the newly introduced flood severity index, which may significantly enhance the interpretation and trustworthiness of risk assessments in the future. The proposed approach and developed indicators are generic and may be replicated and adopted in other coastal megacities around the globe.</p

Pressure Dependence of Born Effective Charges, Dielectric Constant and Lattice Dynamics in SiC

The pressure dependence of the Born effective charge, dielectric constant and zone-center LO and TO phonons have been determined for $3C$-SiC by a linear response method based on the linearized augmented plane wave calculations within the local density approximation. The Born effective charges are found to increase nearly linearly with decreasing volume down to the smallest volume studied, $V/V_0=0.78$, corresponding to a pressure of about 0.8 Mbar. This seems to be in contradiction with the conclusion of the turnover behavior recently reported by Liu and Vohra [Phys.\ Rev.\ Lett.\ {\bf 72}, 4105 (1994)] for $6H$-SiC. Reanalyzing their procedure to extract the pressure dependence of the Born effective charges, we suggest that the turnover behavior they obtained is due to approximations in the assumed pressure dependence of the dielectric constant $\varepsilon_\infty$, the use of a singular set of experimental data for the equation of state, and the uncertainty in measured phonon frequencies, especially at high pressure.Comment: 25 pages, revtex, 5 postscript figures appended, to be published in Phys. Rev.

Glacier thinning, recession and advance, and the associated evolution of a glacial lake between 1966 and 2021 at Austerdalsbreen, western Norway

The Jostedalsbreen is the largest ice cap in Norway and mainland Europe. Rapid retreat of many of its outlet glaciers since the 2000s has led to the formation of several glacial lakes. Processes causing the formation and expansion of glacial lakes and their interaction with a glacier and terminal moraine have not been widely addressed yet. In this study, we investigate the degradation of the front of the southeast-facing outlet glacier Austerdalsbreen. Based on a variety of remotely sensed data (UAV-based and airborne orthophotos and DEMs, satellite images), we analyze the coincident glacial and proglacial changes of Austerdalsbreen and quantify the evolution of this transition zone during the last decades. In particular, we focus on the short-term evolution of the glacial lake since 2010, we examine the context of a glacier advance in the 1990s, and we report long-term changes by utilizing 1960s imagery. We discuss the evolution and conditions of Austerdalsbreen compared to other outlet glaciers of Jostedalsbreen. Overall, the glacier terminus has experienced a recession in the last decades. The 1990s terminus advance was more restricted than at other nearby outlet glaciers due to glacier surface debris cover, which is a critical factor for the glacier and lake evolution. However, in the most recent period, since 2012, a distinct expansion of a glacial lake is quantifiable. Since the rates of glacier surface lowering also considerably increased since approximately 2017 and the glacier retreated since the beginning of the 2000s with a clear maximum length decrease in 2015, we interpret the recently formed glacial lake as a contributory factor of glacial changes

Effects of Methoxyisoflavone, Ecdysterone, and Sulfo-Polysaccharide Supplementation on Training Adaptations in Resistance-Trained Males

PURPOSE: Methoxyisoflavone (M), 20-hydroxyecdysone (E), and sulfo-polysaccharide (CSP3) have been marketed to athletes as dietary supplements that can increase strength and muscle mass during resistancetraining. However, little is known about their potential ergogenic value. The purpose of this study was to determine whether these supplements affect training adaptations and/or markers of muscle anabolism/catabolism in resistance-trained athletes. METHODS: Forty-five resistance-trained males (20.5±3 yrs; 179±7 cm, 84±16 kg, 17.3±9 % body fat) were matched according to FFM and randomly assigned to ingest in a double blind manner supplements containing either a placebo (P); 800 mg/day of M; 200 mg of E; or, 1,000 mg/day of CSP3 for 8-weeks during training. At 0, 4, and 8-weeks, subjects donated fasting blood samples and completed comprehensive muscular strength, muscular endurance, anaerobic capacity, and body composition analysis. Data were analyzed by repeated measures ANOVA. RESULTS: No significant differences (p&gt;0.05) were observed in training adaptations among groups in the variables FFM, percent body fat, bench press 1RM, leg press 1RM or sprint peak power. Anabolic/catabolic analysis revealed no significant differences among groups in active testosterone (AT), free testosterone (FT), cortisol, the AT to cortisol ratio, urea nitrogen, creatinine, the blood urea nitrogen to creatinine ratio. In addition, no significant differences were seen from pr

Low-regret climate change adaptation in coastal megacities – evaluating large-scale flood protection and small-scale rainwater detention measures for Ho Chi Minh City, Vietnam

Urban flooding is a major challenge for many megacities in low-elevation coastal zones (LECZs), especially in Southeast Asia. In these regions, the effects of environmental stressors overlap with rapid urbanization, which significantly aggravates the hazard potential. Ho Chi Minh City (HCMC) in southern Vietnam is a prime example of this set of problems and therefore a suitable case study to apply the concept of low-regret disaster risk adaptation as defined by the Intergovernmental Panel on Climate Change (IPCC). In order to explore and evaluate potential options of hazard mitigation, a hydro-numerical model was employed to scrutinize the effectiveness of two adaptation strategies: (1) a classic flood protection scheme including a large-scale ring dike as currently constructed in HCMC and (2) the widespread installation of small-scale rainwater detention as envisioned in the framework of the Chinese Sponge City Program (SCP). A third adaptation scenario (3) assesses the combination of both approaches (1) and (2). From a hydrological point of view, the reduction in various flood intensity proxies that were computed within this study suggests that large-scale flood protection is comparable but slightly more effective than small-scale rainwater storage: for instance, the two adaptation options could reduce the normalized flood severity index (INFS), which is a measure combining flood depth and duration, by 17.9 % and 17.7 %, respectively. The number of flood-prone manufacturing firms that would be protected after adaptation, in turn, is nearly 2 times higher for the ring dike than for the Sponge City approach. However, the numerical results also reveal that both response options can be implemented in parallel, not only without reducing their individual effectiveness but also complementarily with considerable added value. Additionally, from a governance perspective, decentralized rainwater storage conforms ideally to the low-regret paradigm: while the existing large-scale ring dike depends on a binary commitment (to build or not to build), decentralized small- and micro-scale solutions can be implemented gradually (for example through targeted subsidies) and add technical redundancy to the overall system. In the end, both strategies are highly complementary in their spatial and temporal reduction in flood intensity. Local decision-makers may hence specifically seek combined strategies, adding to singular approaches, and design multi-faceted adaptation pathways in order to successfully prepare for a deeply uncertain future.</p

Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

<p>Abstract</p> <p>Background</p> <p>Since the classic Hopkins and Groom druggable genome review in 2002, there have been a number of publications updating both the hypothetical and successful human drug target statistics. However, listings of research targets that define the area between these two extremes are sparse because of the challenges of collating published information at the necessary scale. We have addressed this by interrogating databases, populated by expert curation, of bioactivity data extracted from patents and journal papers over the last 30 years.</p> <p>Results</p> <p>From a subset of just over 27,000 documents we have extracted a set of compound-to-target relationships for biochemical <it>in vitro </it>binding-type assay data for 1,736 human proteins and 1,654 gene identifiers. These are linked to 1,671,951 compound records derived from 823,179 unique chemical structures. The distribution showed a compounds-per-target average of 964 with a maximum of 42,869 (Factor Xa). The list includes non-targets, failed targets and cross-screening targets. The top-278 most actively pursued targets cover 90% of the compounds. We further investigated target ranking by determining the number of molecular frameworks and scaffolds. These were compared to the compound counts as alternative measures of chemical diversity on a per-target basis.</p> <p>Conclusions</p> <p>The compounds-per-protein listing generated in this work (provided as a supplementary file) represents the major proportion of the human drug target landscape defined by published data. We supplemented the simple ranking by the number of compounds assayed with additional rankings by molecular topology. These showed significant differences and provide complementary assessments of chemical tractability.</p