Equivalence Between Space-Time-Matter and Brane-World Theories

We study the relationship between space-time-matter (STM) and brane theories. These two theories look very different at first sight, and have different motivation for the introduction of a large extra dimension. However, we show that they are equivalent to each other. First we demonstrate that STM predicts local and non-local high-energy corrections to general relativity in 4D, which are identical to those predicted by brane-world models. Secondly, we notice that in brane models the usual matter in 4D is a consequence of the dependence of five-dimensional metrics on the extra coordinate. If the 5D bulk metric is independent of the extra dimension, then the brane is void of matter. Thus, in brane theory matter and geometry are unified, which is exactly the paradigm proposed in STM. Consequently, these two 5D theories share the same concepts and predict the same physics. This is important not only from a theoretical point of view, but also in practice. We propose to use a combination of both methods to alleviate the difficult task of finding solutions on the brane. We show an explicit example that illustrate the feasibility of our proposal.Comment: Typos corrected, three references added. To appear in Mod. Phys. Let

Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise

Background: Muscle regeneration depends on satellite cells, myogenic stem cells that reside on the myofiber surface. Reduced numbers and/or decreased myogenic aptitude of these cells may impede proper maintenance and contribute to the age-associated decline in muscle mass and repair capacity. Endurance exercise was shown to improve muscle performance; however, the direct impact on satellite cells in aging was not yet thoroughly determined. Here, we focused on characterizing the effect of moderate-intensity endurance exercise on satellite cell, as possible means to attenuate adverse effects of aging. Young and old rats of both genders underwent 13 weeks of treadmill-running or remained sedentary. Methodology: Gastrocnemius muscles were assessed for the effect of age, gender and exercise on satellite-cell numbers and myogenic capacity. Satellite cells were identified in freshly isolated myofibers based on Pax7 immunostaining (i.e., exvivo). The capacity of individual myofiber-associated cells to produce myogenic progeny was determined in clonal assays (in-vitro). We show an age-associated decrease in satellite-cell numbers and in the percent of myogenic clones in old sedentary rats. Upon exercise, there was an increase in myofibers that contain higher numbers of satellite cells in both young and old rats, and an increase in the percent of myogenic clones derived from old rats. Changes at the satellite cell level in old rats were accompanied with positive effects on the lean-to-fat Gast muscle composition and on spontaneous locomotion levels. The significance of these data is that they suggest that the endurance exercise-mediated boost in bot