CONTROL OF IRON DEFICIENCYANAEMIA IN PIGLETS THROUGH 2-7-10-15 MODULE OF ORAL IRON SUPPLEMENTATION

Iron deficiency anemia is the leading cause of piglet mortality. It happens due to low iron stores in piglets at birth, increasing body weight with the high demand for hemoglobin carrying red blood cells, presence of a very low amount of iron in sow’s milk, and immature mechanism of iron absorption in piglets. Iron supplementation is the only way to control it. The present study investigated the efficacy of oral iron supplementation in two different doses @ 30 mg/kg body weight and 150 mg/ kg body weight on suckling piglet performance, control of iron deficiency anemia, and blood as well as organ iron status. The iron supplementation was given on the 2nd, 7th, 10th, and 15 th- day post birth. Oral iron supplementation to piglets improved growth parameters, hemoglobin level, serum Fe and serum ferritin levels, and organ (liver and spleen) Fe levels. Moreover, at weaning, hemoglobin levels of supplemented piglets were normal whereas the un-supplemented piglets were suffering from iron deficiency anemia. Therefore, oral iron supplementation @ of 30 mg/kg body weight on 2-7-10-15 days post-birth may be recommended for control of iron deficiency anemia and improvement of iron status in piglets

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Development and application of SPI generator using open source for analyzing drought at a varying time scale

The Standardized Precipitation Index (SPI) is a probability index that gives a belier representation of abnormal wetness and dryness than any other drought indices. The primary objective of the current study is to develop a comprehensive tool to compute SPI on a spatial basis and analyze spa!iotemporal variability of drought in North West Indian region during 1951-2007 using APHRODITE waler resource data at 0.25-degree resolution. This tool was developed using the python programming language, and the site-packages such as Numpy, Scipy, Ma!plo!lib, Ne!CDF, PyQt were used. The result showed Iha! the SPI time series showed significant inter-annual and multi-decadal variations. In the whole data period, three consecutive droughts have occurred only once, 1999-2002. This prolonged drought hurt the agricultural and water resources sectors over the study area. The computed SPI for the year2002 showed an extreme dry spell over the study area signifying the major drought over India in the same year with a 56% deficit of rainfall in July. The computed 12-month SPI for the year 1996 shows a wet period over the northwestern part of India, especially over Haryana signifying medium to heavy rainfall, conforming 1996 flood. The developed SPI tool, portray a realistic picture of drought scenario over the Northwest region and improve the timely identification of emerging drought conditions that can trigger appropriate responses by the decision makers

Origin, genetic diversity and evolution of Andaman local duck, a native duck germplasm of an insular region of India.

Domestic ducks are of paramount importance as a cheap source of protein in rural India. Andaman local duck (ALD) is an indigenous avian genetic resource of Andaman and Nicobar islands (ANI) and is mainly distributed in Middle and Northern parts of these islands. Negligence has brought this breed on the edge of extinction necessitating immediate conservation efforts. Here, we report the genetic diversity, population structure and matrilineal genetic root of ALD. Partial mtDNA D-loop sequences were analyzed in 71 ALD samples and analysis revealed 19 polymorphic sites and 13 haplotypes. Estimated haplotype (Hd ± SD) and nucleotide diversity (π ± SD) were 0.881 ± 0.017 and 0.00897 ± 0.00078 respectively. The high genetic diversity of ALD indicates introgression of genetic material from other local duck breeds. In addition, it can be postulated that ALD bearing high genetic diversity has strong ability to adapt to environmental changes and can withstand impending climate change. Phylogenetic and network analysis indicate that ALD falls under Eurasian clade of mallard and ALD forms three clusters; one cluster is phylogenetically close to Southeast Asian countries, one close to Southern part of mainland India and the third one forms an independent cluster. Therefore, ALD might have migrated either from Southeast Asian countries which enjoy a close cultural bondage with ANI from time immemorial or from Southern part of India. The independent cluster may have evolved locally in these islands and natural selection pressure imposed by environmental conditions might be the driving force for evaluation of these duck haplotypes; which mimics Darwin's theory of natural selection. The results of the study will be beneficial for formulating future breeding programme and conservation strategy towards sustainable development of the duck breed

Multiple gene co-options underlie the rapid evolution of sexually deceptive flowers in Gorteria diffusa.

Gene co-option, the redeployment of an existing gene in an unrelated developmental context, is an important mechanism underlying the evolution of morphological novelty. In most cases described to date, novel traits emerged by co-option of a single gene or genetic network. Here, we show that the integration of multiple co-opted genetic elements facilitated the rapid evolution of complex petal spots that mimic female bee-fly pollinators in the sexually deceptive South African daisy Gorteria diffusa. First, co-option of iron homeostasis genes altered petal spot pigmentation, producing a color similar to that of female pollinators. Second, co-option of the root hair gene GdEXPA7 enabled the formation of enlarged papillate petal epidermal cells, eliciting copulation responses from male flies. Third, co-option of the miR156-GdSPL1 transcription factor module altered petal spot placement, resulting in better mimicry of female flies resting on the flower. The three genetic elements were likely co-opted sequentially, and strength of sexual deception in different G. diffusa floral forms strongly correlates with the presence of the three corresponding morphological alterations. Our findings suggest that gene co-options can combine in a modular fashion, enabling rapid evolution of novel complex traits

Optimization of synthesis protocols to control the nanostructure and the morphology of metal oxide thin films for memristive applications

Abstract. We propose a multi-technique approach based on in-vacuum synthesis of metal oxides to optimize the memristive properties of devices that use a metal oxide thin film as insulating layer. Pulsed Microplasma Cluster Source (PMCS) is based on supersonic beams seeded by clusters of the metal oxide. Nanocrystalline TiO 2 thin films can be grown at room temperature, controlling the oxide stoichiometry from titanium metal up to a significant oxygen excess. Pulsed Electron beam Deposition (PED) is suitable to grow crystalline thin films on large areas, a step towards producing device arrays with controlled morphology and stoichiometry. Atomic Layer Deposition (ALD) is a powerful technique to grow materials layer-by-layer, finely controlling the chemical and structural properties of the film up to thickness of 50-80 nm. We will present a few examples of metal-insulator-metal structures showing a pinched hysteresis loop in their current-voltage characteristic. The structure, stoichiometry and morphology of the metal oxide layer, either aluminum oxide or titanium dioxide, is investigated by means of scanning electron microscopy (SEM) and by Raman scattering