QSO 0130-4021: A third QSO showing a low Deuterium to Hydrogen Abundance Ratio

We have discovered a third quasar absorption system which is consistent with a low deuterium to hydrogen abundance ratio, D/H = 3.4 times 10^-5. The z ~ 2.8 partial Lyman limit system towards QSO 0130-4021 provides the strongest evidence to date against large D/H ratios because the H I absorption, which consists of a single high column density component with unsaturated high order Lyman series lines, is readily modeled -- a task which is more complex in other D/H systems. We have obtained twenty-two hours of spectra from the HIRES spectrograph on the W.M. Keck telescope, which allow a detailed description of the Hydrogen. We see excess absorption on the blue wing of the H I Lyman alpha line, near the expected position of Deuterium. However, we find that Deuterium cannot explain all of the excess absorption, and hence there must be contamination by additional absorption, probably H I. This extra H I can account for most or all of the absorption at the D position, and hence D/H = 0 is allowed. We find an upper limit of D/H < 6.7 times 10^-5 in this system, consistent with the value of D/H ~ 3.4 times 10^-5 deduced towards QSO 1009+2956 and QSO 1937-1009 by Burles and Tytler (1998a, 1998b). This absorption system shows only weak metal line absorption, and we estimate [Si/H] < -2.6 -- indicating that the D/H ratio of the system is likely primordial. All four of the known high redshift absorption line systems simple enough to provide useful limits on D are consistent with D/H = 3.4 +/- 0.25 times 10^-5. Conversely, this QSO provides the third case which is inconsistent with much larger values.Comment: 18 pages, 5 figures, submitted to Ap

Acute hypoxic respiratory failure due to Lenalidomide-induced interstitial pneumonitis in a patient with multiple myeloma

BackgroundPatients with multiple myeloma are immunosuppressed due to both the disease itself and immunosuppressive therapies. Thus, when presenting with respiratory failure and pulmonary opacities, pneumonia must be considered. However, while rare, immunomodulating medications used in the treatment of multiple myeloma can also cause potentially life-threatening respiratory failure, a distinction which has important treatment implications.Case presentationAn 80-year-old male with recently diagnosed multiple myeloma undergoing treatment with lenalidomide and daratumumab presented with acute, rapidly progressive hypoxic respiratory failure ultimately requiring intubation and mechanical ventilatory support. Imaging revealed bilateral pulmonary opacities, however infectious workup was negative, and he was ultimately diagnosed with lenalidomide-induced interstitial pneumonitis, a rare but serious adverse effect of this medication. He was treated with drug discontinuation and methylprednisolone, and quickly recovered.ConclusionLenalidomide is an immunomodulating medication used in the treatment of multiple myeloma, and is associated with rare but serious cases of drug-induced interstitial pneumonitis. Thus, if a patient receiving lenalidomide develops shortness of breath and/or hypoxia, drug-induced pneumonitis must be on the differential. Permanent drug discontinuation with or without corticosteroids is the mainstay of treatment, and patients are often able to fully recover, underscoring the need for early recognition of this condition

Archeops: an instrument for present and future cosmology

Archeops is a balloon-borne instrument dedicated to measure the cosmic microwave background (CMB) temperature anisotropies. It has, in the millimetre domain (from 143 to 545 GHz), a high angular resolution (about 10 arcminutes) in order to constrain high l multipoles, as well as a large sky coverage fraction (30%) in order to minimize the cosmic variance. It has linked, before WMAP, Cobe large angular scales to the first acoustic peak region. From its results, inflation motivated cosmologies are reinforced with a flat Universe (Omega_tot=1 within 3%). The dark energy density and the baryonic density are in very good agreement with other independent estimations based on supernovae measurements and big bang nucleosynthesis. Important results on galactic dust emission polarization and their implications for Planck are also addressed.Comment: 4 pages, 2 figures, to appear in Proceedings of the Multiwavelength Cosmology Conference, June 2003, Mykonos Island, Greec

The Deuterium to Hydrogen Abundance Ratio Towards a Fourth QSO: HS0105+1619

We report the measurement of the primordial D/H abundance ratio towards QSO \object. The column density of the hydrogen in the $z \simeq 2.536$ Lyman limit system is high, \lnhi $= 19.422 \pm 0.009$ \cmm, allowing for the deuterium to be seen in 5 Lyman series transitions. The measured value of the D/H ratio towards QSO \object is found to be D/H$= 2.54 \pm 0.23 \times 10^{-5}$. The metallicity of the system showing D/H is found to be $\simeq 0.01$ solar, indicating that the measured D/H is the primordial D/H within the measurement errors. The gas which shows D/H is neutral, unlike previous D/H systems which were more highly ionized. Thus, the determination of the D/H ratio becomes more secure since we are measuring it in different astrophysical environments, but the error is larger because we now see more dispersion between measurements. Combined with prior measurements of D/H, the best D/H ratio is now D/H$= 3.0 \pm 0.4 \times 10^{-5}$, which is 10% lower than the previous value. The new values for the baryon to photon ratio, and baryonic matter density derived from D/H are $\eta = 5.6 \pm 0.5 \times 10^{-10}$ and \ob $=0.0205 \pm 0.0018$ respectively.Comment: Minor text and reference changes. To appear in the May 10, 2001 issue of the Astrophysical Journa

Antigen receptor repertoires of one of the smallest known vertebrates

The rules underlying the structure of antigen receptor repertoires are not yet fully defined, despite their enormous importance for the understanding of adaptive immunity. With current technology, the large antigen receptor repertoires of mice and humans cannot be comprehensively studied. To circumvent the problems associated with incomplete sampling, we have studied the immunogenetic features of one of the smallest known vertebrates, the cyprinid fish Paedocypris sp. “Singkep” (“minifish”). Despite its small size, minifish has the key genetic facilities characterizing the principal vertebrate lymphocyte lineages. As described for mammals, the frequency distributions of immunoglobulin and T cell receptor clonotypes exhibit the features of fractal systems, demonstrating that self-similarity is a fundamental property of antigen receptor repertoires of vertebrates, irrespective of body size. Hence, minifish achieve immunocompetence via a few thousand lymphocytes organized in robust scale-free networks, thereby ensuring immune reactivity even when cells are lost or clone sizes fluctuate during immune responses

The kinetic temperature in a damped Lyman-alpha absorption system in Q2206-199 - an example of the warm neutral medium

By comparing the widths of absorption lines from OI, SiII and FeII in the redshift z=2.076 single-component damped Lyman alpha absorption system in the spectrum of Q2206-199 we establish that these absorption lines arise in Warm Neutral Medium gas at ~12000 +/- 3000K. This is consistent with thermal equilibrium model estimates of ~ 8000K for the Warm Neutral Medium in galaxies, but not with the presence of a significant cold component. It is also consistent with, but not required by, the absence of CII* fine structure absorption in this system. Some possible implications concerning abundance estimates in narrow-line WNM absorbers are discussed.Comment: 9 pages, 3 figures. MNRAS accepte

Spontaneous baryogenesis in flat directions

We discuss a spontaneous baryogenesis mechanism in flat directions. After identifying the Nambu-Goldstone mode which derivatively couples to the associated $U$(1) current and rotates due to the A-term, we show that spontaneous baryogenesis can be naturally realized in the context of the flat direction. As applications, we discuss two scenarios of baryogenesis in detail. One is baryogenesis in a flat direction with a vanishing $B-L$ charge, especially, with neither baryon nor lepton charge, which was recently proposed by Chiba and the present authors. The other is a baryogenesis scenario compatible with a large lepton asymmetry.Comment: 10 pages, no figure, the version accepted to Phys. Rev. D; a few explanatory comments are adde

MUSE Analysis of Gas around Galaxies (MAGG) - I: Survey design and the environment of a near pristine gas cloud at z ≈ 3.5

We present the design, methods, and first results of the MUSE Analysis of Gas around Galaxies (MAGG) survey, a large programme on the Multi Unit Spectroscopic Explorer (MUSE) instrument at the Very Large Telescope (VLT) which targets 28 z > 3.2 quasars to investigate the connection between optically-thick gas and galaxies at z ∼ 3 − 4. MAGG maps the environment of 52 strong absorption line systems at z ≳ 3, providing the first statistical sample of galaxies associated with gas-rich structures in the early Universe. In this paper, we study the galaxy population around a very metal poor gas cloud at z ≈ 3.53 towards the quasar J124957.23−015928.8. We detect three Lyα emitters within ≲200 km s−1 of the cloud redshift, at projected separations ≲185 kpc (physical). The presence of star-forming galaxies near a very metal-poor cloud indicates that metal enrichment is still spatially inhomogeneous at this redshift. Based on its very low metallicity and the presence of nearby galaxies, we propose that the most likely scenario for this LLS is that it lies within a filament which may be accreting onto a nearby galaxy. Taken together with the small number of other LLSs studied with MUSE, the observations to date show a range of different environments near strong absorption systems. The full MAGG survey will significantly expand this sample and enable a statistical analysis of the link between gas and galaxies to pin down the origin of these diverse environments at z ≈ 3 − 4

Characterisation and Bioactivity Analysis of Peridinin-Chlorophyll a-Protein (PCP) Isolated from Symbiodinium tridacnidorum CS-73

Peridinin-Chlorophyll a-Proteins (PCP) are the major light harvesting proteins in photosynthetic dinoflagellates. PCP shows great variation in protein length, pigment ratio, sequence, and spectroscopic properties. PCP conjugates (PerCP) are widely used as fluorescent probes for cellular and tissue analysis in the biomedical field. PCP consists of a peridinin carotenoid; thereby, it can potentially be used as a bioactive compound in pharmaceutical applications. However, the biological activities of PCP are yet to be explored. In this study, we extracted, purified, and partially characterised the PCP from Symbiodinium tridacnidorum (CS-73) and explored its antioxidant, anti-cancer and anti-inflammation bioactivities. The PCP was purified using an ÄKTA™ PURE system and predicted to be of 17.3 kDa molecular weight (confirmed as a single band on SDS-PAGE) with an isoelectric point (pI) 5.6. LC-MS/MS and bioinformatic analysis of purified PCP digested with trypsin indicated it was 164 amino acids long with >90% sequence similarity to PCP of SymA3.s6014_g3 (belonging to clade A of Symbiodinium sp.) confirmed with 59 peptide combinations matched across its protein sequence. The spectroscopic properties of purified PCP showed a slight shift in absorption and emission spectra to previously documented analysis in Symbiodinium species possibly due to variation in amino acid sequences that interact with chl a and peridinin. Purified PCP consisted of a 19-amino-acid-long signal peptide at its N terminal and nine helixes in its secondary structure, with several protein binding sites and no DNA/RNA binding site. Furthermore, purified PCP exhibited antioxidant and in vitro anti-inflammation bioactivities, and anti-cancer activities against human metastatic breast adenocarcinoma (MDA-MB-231) and human colorectal (HTC-15) cancer cell lines. Together, all these findings present PCP as a promising candidate for continued investigations for pharmaceutical applications to cure chronic diseases, apart from its existing application as a fluorescent-probe.</jats:p

Early-universe constraints on a time-varying fine structure constant

Higher-dimensional theories have the remarkable feature of predicting a time (and hence redshift) dependence of the `fundamental' four dimensional constants on cosmological timescales. In this paper we update the bounds on a possible variation of the fine structure constant alpha at the time of BBN (z =10^10) and CMB (z=10^3). Using the recently-released high-resolution CMB anisotropy data and the latest estimates of primordial abundances of 4He and D, we do not find evidence for a varying alpha at more than one-sigma level at either epoch.Comment: 5 pages, 1 figure, minor misprints corrected, references added. The analysis has been updated using new BOOMERanG and DASI data on CMB anisotrop