The story so far: Helicobacter pylori and gastric autoimmunity

The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump

The Family Campylobacteraceae

The Campylobacteraceae is the largest and most diverse family in the phylogenetically distinct Epsilonproteobacteria, presently comprising the genera Campylobacter (30 taxa), Arcobacter (17 taxa), and Sulfurospirillum (7 taxa). Individual species may be able to grow in microaerobic, anaerobic, and/or aerobic conditions, in temperatures from 25°C to 42°C; free-living, commensal, or pathogenic; motile or aflagellate; and able to colonize the oral cavity, intestine, stomach, or reproductive tracts of humans, large production animals (such as sheep, cattle, and deer), birds, and reptiles. Some species are known to be among the most frequent causes of human gastroenteritis, others are significant threats to bovine and ovine fertility, and many pose an as-yet unknown, or no, role in human or animal diseases. The taxonomy of the Campylobacteraceae has evolved extensively since its beginnings in 1963. This chapter outlines key events in the family's taxonomic history; reviews general phenotypic traits of each genus, including their isolation; outlines the clinical (including pathogenicity studies and antimicrobial resistance traits) and/or ecological significance of constituent species; and describes current approaches and challenges for species identification and epidemiological subtyping