Efficient low-threshold lasers based on an erbium-doped holey fiber

We report experimental results on the continuous-wave lasers based on a small core erbium-doped holey fiber. In a simple Fabry-Perot-type cavity with high output coupling, we demonstrate low-threshold (0.55 mW) high slope-efficiency (57.3%) operation confirming both the quality and exceptionally high gain efficiency of the fiber. In an all-fiber ring cavity where the cavity loss is reduced, we show that it is possible to achieve a low-threshold laser with extremely wide tunability (>100 nm around 1550 nm). Our results illustrate some of the unique opportunities provided by active small core holey fibers

Alterations of [3H]Forskolin Binding in the Postischemic Rat Brain

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Development of a New in vivo Double Autoradiogram for the Analysis of Dopaminergic System of the Rat Brain

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Alterations of Second Messenger and Neurotransmitter Receptor Systems in the Exo-Focal Postischemic Brain Areas of the Rat: In vitro Autoradiographic Study

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Alterations in Neurotransmitter-Receptor and Second-Messenger System Binding in the Gerbil Hippocampus Following Repeated Ischemic Insults

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Detection of serum soluble markers of immune activation in rheumatoid arthritis

The mutual correlation among soluble CD4 (sCD4), soluble CD8 (sCD8), and soluble CD23 (sCD23) has not yet been studied in patients with rheumatoid arthritis (RA), although previous studies have demonstrated that certain soluble markers of immune activation are elevated in RA. Thus, we examined this correlation based on the serum levels of sCD4, sCD8 and sCD23, and that of their levels with other serum markers such as immunoglobulin (Ig) subtypes (IgG, IgM and IgA), IgM-rheumatoid factor (IgM-RF) and C-reactive protein (CRP) in 25 RA patients, sCD4 was not elevated, whereas both sCD8 and sCD23 increased in RA patients compared with the healthy controls; a majority of RA patients, in particular, showed a high sCD23 level. The level of sCD23 showed a correlation with that of IgM-RF, but not with those of IgG, IgM, IgA and CRP. Importantly, a high level of sCD23 was not always accompartied with that of sCD8. The independent change between sCD23 and sCD8 levels was also observed in a one-year follow-up study of the two RA patients. These findings indicate that B cells might be generally activated in RA, whereas T-cell activation in variable in each patient with RA, suggesting that sCD23 is a more indicative marker for the immune status of RA patients than sCD8 from the clinical aspects

Contribution of Rat Brain Microvessels to the Whole Brain on 18F-2-Deoxy-2-Fluoro-D-Glucose Metabolism

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Development and some applications of enzyme-linked immunosorbent assay system for murine macrophage inflammatory protein-2 (MIP-2)

We attempted to establish an enzyme-linked immunosorbent assay (ELISA) system by preparation of recombinant murine MIP-2 and its rabbit antibodies. A fusion construct of MIP-2 to protein A was used to enable easy purification as well as the generation of a sufficiently large antibody response. The specificity of antibody was confirmed by Western blotting analysis of 20-h conditioned medium from lipopolysaccharide (LPS)-stimulated RAW264.7 cells, a murine macrophage cell line; antibody gave a single band with a molecular weight of approximately 6000, which is identical to that of murine MIP-2 reported previously. Biotin–streptavidin sandwich ELISA could detect quantitatively MIP-2 at concentration range of 20 to 1000 pg/ml. In some applications of this ELISA system, time-related production of MIP-2 and inhibitory effect of dexamethasone on its production have been demonstrated in LPS-stimulated RAW264.7 cells. Thus, ELISA system established in this study is considered to be a useful tool to study MIP-2 response in various inflammation models in mice