415 research outputs found

    Severe hepatic injury caused by orlistat

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    ArticleAMERICAN JOURNAL OF MEDICINE. 119(8): E7-E7journal articl

    Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan

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    © 2006 by [The University of Chicago Press ]ArticleCLINICAL INFECTIOUS DISEASES. 47(5):E52-E56(2008)journal articl

    Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines

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    ArticleJOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 97(1-2): 173-177 (2005)journal articl

    Epidemiology of hepatocellular carcinoma in Japan

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    The original publication is available at www.springerlink.comArticleJOURNAL OF GASTROENTEROLOGY. 44:102-107 (2009)journal articl

    IgG4-related sclerosing cholangitis should be included as an exclusion criterion for the diagnosis of primary sclerosing cholangitis

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    The definitive version is available at www.blackwell-synergy.com.ArticleAMERICAN JOURNAL OF GASTROENTEROLOGY. 102(3): 691-692 (2007)journal articl

    Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis

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    This is a preprint of an article published in INTERNATIONAL JOURNAL OF CANCER. Copyright (c) 2008 Wiley-Liss, Inc., A Wiley CompanyArticleINTERNATIONAL JOURNAL OF CANCER. 122(1): 124-131journal articl

    Pancreatic exocrine insufficiency: a rare cause of nonalcoholic steatohepatitis

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    This is an electronic version of an Article published in the American Journal of Gastroenterology 2008; 103(1): 245-246.ArticleAmerican journal of gastroenterology. 103(1): 245-246 (2008)journal articl

    Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress

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    Background/Aims: Alcoholic liver disease (ALD) is one of the leading causes of cirrhosis and yet efficient therapeutic strategies are lacking. Polyenephosphatidylcholine (PPC), a major component of essential phospholipids, prevented alcoholic liver fibrosis in baboons, but its precise mechanism remains uncertain. We aimed to explore the effects of PPC on ALD using ethanol-fed peroxisome proliferator-activated receptor α (Ppara)-null mice, showing several similarities to human ALD. Methods: Male wild-type and Ppara-null mice were pair-fed a Lieber-DeCarli control or 4% ethanol-containing diet with or without PPC (30 mg/kg/day) for 6 months. Results: PPC significantly ameliorated ethanol-induced hepatocyte damage and hepatitis in Ppara-null mice. These effects were likely a consequence of decreased oxidative stress through down-regulation of reactive oxygen species (ROS)-generating enzymes, including cytochrome P450 2E1, acyl-CoA oxidase, and NADPH oxidases, in addition to restoration of increases in Toll-like receptor 4 and CD14. PPC also decreased Bax and truncated Bid, thus inhibiting apoptosis. Furthermore, PPC suppressed increases in transforming growth factor-β1 expression and hepatic stellate cell activation, which retarded hepatic fibrogenesis. Conclusions: PPC exhibited anti-inflammatory, anti-apoptotic, and anti-fibrotic effects on ALD as a result of inhibition of the overexpression of ROS-generating enzymes. Our results demonstrate detailed molecular mechanisms of the anti-oxidant action of PPC.ArticleJournal of Hepatology 50(6): 1236-1246(2009)journal articl

    Anti-Helicobacter pylori seropositivity: influence on severity and treatment response in patients with chronic hepatitis C

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    The definitive version is available at www.blackwell-synergy.comArticleJOURNAL OF VIRAL HEPATITIS. 14(1): 48-54 (2007)journal articl
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