Aspirin Resistance

The development of adverse cardiovascular events despite aspirin use has established an interest in a possible resistance to the drug. Several definitions have been set and various laboratory testing modalities are available. This has led to a wide range of prevalence reports in different clinical entities. The etiologic mechanism has been related to clinical, genetic, and other miscellaneous factors. The clinical implications of this phenomenon are significant and warrant concern. Management strategies are currently limited to dosing alteration and introduction of other anitplatelet agents. However, these measures have not met the expected efficacy or safety

Utilization of Arabic Calligraphy to Promote the Arabic Identity in Packaging Designs

Letters are considered an important element in graphic design. Arabic calligraphy, specifically, is an important art that give letters aesthetic form. Arabic letters are used in many different ways to form words. These words are then used in typography giving information and communicating with consumers. In Arabic packaging designs, Arabic letters are not yet utilized to give the cultural identity to the brand and graphic design of the Arabic products in general. This paper focuses at using Arabic letters and digital calligraphy to enhance packaging identity of Arabian products. Keywords: Arabic calligraphy, typography, lettering, identity, digital calligraphy, packaging desig

Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.

The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a late-evolving epidermal appendage that has the primary function of providing nutrition for the young, although recent studies have highlighted additional benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psychosocial benefits of breastfeeding. In this Review, we outline the various stages of mammary gland development in the mouse, with a particular focus on lineage specification and the new insights that have been gained by the application of recent technological advances in imaging in both real-time and three-dimensions, and in single cell RNA sequencing. These studies have revealed the complexity of subpopulations of cells that contribute to the mammary stem and progenitor cell hierarchy and we suggest a new terminology to distinguish these cells.CRUK Career Establishment Award (C47525/A17348

Mechanisms of Renal Disease in β-Thalassemia

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Communication-Efficient Federated Learning For LEO Constellations Integrated With HAPs Using Hybrid NOMA-OFDM

Space AI has become increasingly important and sometimes even necessary for government, businesses, and society. An active research topic under this mission is integrating federated learning (FL) with satellite communications (SatCom) so that numerous low Earth orbit (LEO) satellites can collaboratively train a machine learning model. However, the special communication environment of SatCom leads to a very slow FL training process up to days and weeks. This paper proposes NomaFedHAP, a novel FL-SatCom approach tailored to LEO satellites, that (1) utilizes high-altitude platforms (HAPs) as distributed parameter servers (PSs) to enhance satellite visibility, and (2) introduces non-orthogonal multiple access (NOMA) into LEO to enable fast and bandwidth-efficient model transmissions. In addition, NomaFedHAP includes (3) a new communication topology that exploits HAPs to bridge satellites among different orbits to mitigate the Doppler shift, and (4) a new FL model aggregation scheme that optimally balances models between different orbits and shells. Moreover, we (5) derive a closed-form expression of the outage probability for satellites in near and far shells, as well as for the entire system. Our extensive simulations have validated the mathematical analysis and demonstrated the superior performance of NomaFedHAP in achieving fast and efficient FL model convergence with high accuracy as compared to the state-of-the-art

Domestic thermoelectric cogeneration system optimization analysis, energy consumption and CO 2 emissions reduction

In this paper, a domestic thermoelectric cogeneration system (DCS) is suggested. This system permits to use the lost heat of exhaust gases to simultaneously heat water and produce electricity via thermoelectric generators (TEG). To proceed, the concept of the system is drawn and the corresponding thermal modeling is developed. An optimization analysis, based on the position of the thermoelectric generators within the system, is carried out using the thermal modeling. The TEGs are places on the inner or outer walls of the tank or the pipe (cases 2–5), or on all of them (case 6). Results show that water can be heated to up to 97 °C, when TEGs are located on the inner wall of the tank. More the TEGs are nearer to the exhaust gases, higher is the total power produced by the TEGs and lower is the water temperature. The power produced by one TEG in direct contact with the exhaust gases is 0.35 W and the water temperature is 76 °C. Also, a DCS with TEG located at all layers can generate up to 52 W and 81 °C hot water, however this configuration has high initial cost. An economic and environmental concerns are considered. Results show that DCS with TEGs located on the inner wall of the pipe has a payback period of 1 year and 8 months when water is heated 60 times per month. In addition to that, it was shown that the location of TEGs do not affect the amount of CO2 gas reduced which is about 6 tons yearly. Finally, this study shows that the configuration where TEGs are placed at the inner wall of the pipe is the most cost-effective energy recovery configuration