Aspirin Resistance

The development of adverse cardiovascular events despite aspirin use has established an interest in a possible resistance to the drug. Several definitions have been set and various laboratory testing modalities are available. This has led to a wide range of prevalence reports in different clinical entities. The etiologic mechanism has been related to clinical, genetic, and other miscellaneous factors. The clinical implications of this phenomenon are significant and warrant concern. Management strategies are currently limited to dosing alteration and introduction of other anitplatelet agents. However, these measures have not met the expected efficacy or safety

Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.

The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a late-evolving epidermal appendage that has the primary function of providing nutrition for the young, although recent studies have highlighted additional benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psychosocial benefits of breastfeeding. In this Review, we outline the various stages of mammary gland development in the mouse, with a particular focus on lineage specification and the new insights that have been gained by the application of recent technological advances in imaging in both real-time and three-dimensions, and in single cell RNA sequencing. These studies have revealed the complexity of subpopulations of cells that contribute to the mammary stem and progenitor cell hierarchy and we suggest a new terminology to distinguish these cells.CRUK Career Establishment Award (C47525/A17348

Utilization of Arabic Calligraphy to Promote the Arabic Identity in Packaging Designs

Letters are considered an important element in graphic design. Arabic calligraphy, specifically, is an important art that give letters aesthetic form. Arabic letters are used in many different ways to form words. These words are then used in typography giving information and communicating with consumers. In Arabic packaging designs, Arabic letters are not yet utilized to give the cultural identity to the brand and graphic design of the Arabic products in general. This paper focuses at using Arabic letters and digital calligraphy to enhance packaging identity of Arabian products. Keywords: Arabic calligraphy, typography, lettering, identity, digital calligraphy, packaging desig

Domestic thermoelectric cogeneration system optimization analysis, energy consumption and CO 2 emissions reduction

In this paper, a domestic thermoelectric cogeneration system (DCS) is suggested. This system permits to use the lost heat of exhaust gases to simultaneously heat water and produce electricity via thermoelectric generators (TEG). To proceed, the concept of the system is drawn and the corresponding thermal modeling is developed. An optimization analysis, based on the position of the thermoelectric generators within the system, is carried out using the thermal modeling. The TEGs are places on the inner or outer walls of the tank or the pipe (cases 2–5), or on all of them (case 6). Results show that water can be heated to up to 97 °C, when TEGs are located on the inner wall of the tank. More the TEGs are nearer to the exhaust gases, higher is the total power produced by the TEGs and lower is the water temperature. The power produced by one TEG in direct contact with the exhaust gases is 0.35 W and the water temperature is 76 °C. Also, a DCS with TEG located at all layers can generate up to 52 W and 81 °C hot water, however this configuration has high initial cost. An economic and environmental concerns are considered. Results show that DCS with TEGs located on the inner wall of the pipe has a payback period of 1 year and 8 months when water is heated 60 times per month. In addition to that, it was shown that the location of TEGs do not affect the amount of CO2 gas reduced which is about 6 tons yearly. Finally, this study shows that the configuration where TEGs are placed at the inner wall of the pipe is the most cost-effective energy recovery configuration

Review of the radiographic modalities used during dental implant therapy - A narrative

The introduction of digital x-ray receivers which replaced conventional films was a significant radiographic development that is commonly used in daily dental practice. Dental implant therapy (DIT) is a sought after dental therapeutic intervention and dental radiography is an essential component contributing to the success of treatment. Dental radiographs taken in daily practice are generally conventional two-dimensional images and/or three-dimensional images. Ideally, the choice of radiographic technique should be determined after a thorough clinical examination and comprehensive consideration of the advantages, indications, and drawbacks. Digital three-dimensional modalities that have emerged over the last decade have been incorporated into DIT with the assumption that treatment outcomes will be improved. These modalities are constantly being reassessed and improved but there is a paucity of published information regarding the assessment of variables such as dosages and dimensional accuracy, suggesting that further research in these matters is necessary. This is crucial in order to obtain evidence-based information that may influence future radiographic practices. In this narrative, the authors present the most commonly used dental radiographic modalities currently used in DIT

Left-Sided Congenital Diaphragmatic Hernia with Multiple Congenital Cardiac Anomalies, Hernia Sac, and Microscopic Hepatic Heterotopia: A Case Report

Congenital diaphragmatic hernia is a common congenital anomaly of uncertain etiology. Its association with multiple congenital anomalies in various organs is well recognized and antenatal radiological evidence of congenital diaphragmatic hernia warrants thorough evaluation to detect other anomalies, some of which can be life threatening. Rarely, heterotopic hepatic tissue is identified in the hernia, a rare pathological finding, exhibiting more than one macroscopic and microscopic characteristics, and always associated with cardiac congenital anomalies. Herein, we report a case of left-sided microscopic heterotopic hepatic tissue in a congenital diaphragmatic hernia in an infant with multiple cardiac congenital anomalies, but with preserved pericardium