The CogBIAS longitudinal study protocol: cognitive and genetic factors influencing psychological functioning in adolescence.

BACKGROUND: Optimal psychological development is dependent upon a complex interplay between individual and situational factors. Investigating the development of these factors in adolescence will help to improve understanding of emotional vulnerability and resilience. The CogBIAS longitudinal study (CogBIAS-L-S) aims to combine cognitive and genetic approaches to investigate risk and protective factors associated with the development of mood and impulsivity-related outcomes in an adolescent sample. METHODS: CogBIAS-L-S is a three-wave longitudinal study of typically developing adolescents conducted over 4 years, with data collection at age 12, 14 and 16. At each wave participants will undergo multiple assessments including a range of selective cognitive processing tasks (e.g. attention bias, interpretation bias, memory bias) and psychological self-report measures (e.g. anxiety, depression, resilience). Saliva samples will also be collected at the baseline assessment for genetic analyses. Multilevel statistical analyses will be performed to investigate the developmental trajectory of cognitive biases on psychological functioning, as well as the influence of genetic moderation on these relationships. DISCUSSION: CogBIAS-L-S represents the first longitudinal study to assess multiple cognitive biases across adolescent development and the largest study of its kind to collect genetic data. It therefore provides a unique opportunity to understand how genes and the environment influence the development and maintenance of cognitive biases and provide insight into risk and protective factors that may be key targets for intervention.This work was supported by the European Research Council (ERC) under the European Union’s Seventh Framework Programme (FP7/2007–2013)/ERC grant agreement no: [324176]

The Role of Kiwifruit in Supporting Psychological Well-Being: A Rapid Review of the Literature

Consumption of vitamin-rich fruits and vegetables is emerging as a recommendation for the prevention and treatment of depression and anxiety. This review sought to examine literature investigating the role of kiwifruit in supporting psychological well-being in adult populations through increased vitamin C intake. The literature search using CINAHL, Embase and PubMed databases was restricted to English-language articles published from 2005 through July 2022. Inclusion criteria were randomized trials that delivered kiwifruit interventions to adult populations assessing psychological well-being. Studies were assessed for bias using the Joanna Briggs Institute critical appraisal tool for randomized controlled trials. The literature search identified two eligible trials involving 202 participants that delivered gold kiwifruit interventions and evaluated aspects of psychological well-being (e.g., mood disturbance, vitality, vigour, depression). Daily consumption of two gold kiwifruit was associated with significant reductions in mood disturbance and fatigue, and significant increases in well-being and vigour. Larger effects were observed in participants with higher baseline mood disturbance. Additional research involving a broader range of cohorts and isolating the effects of other micronutrients within gold kiwifruit implicated in the pathophysiology of depression is warranted. Overall, preliminary evidence suggests that daily consumption of two gold kiwifruit might improve psychological well-being in adult populations

Impulsivity-based thrifty eating phenotype and the protective role of n-3 PUFAs intake in adolescents

The goal of the present study was to investigate whether intrauterine growth restriction (IUGR) affects brain responses to palatable foods and whether docosahexaenoic acid (DHA, an omega-3 fatty acid that is a primary structural component of the human brain) serum levels moderate the association between IUGR and brain and behavioral responses to palatable foods. Brain responses to palatable foods were investigated using a functional magnetic resonance imaging task in which participants were shown palatable foods, neutral foods and non-food items. Serum DHA was quantified in blood samples, and birth weight ratio (BWR) was used as a proxy for IUGR. The Dutch Eating Behavior Questionnaire (DEBQ) was used to evaluate eating behaviors. In the contrast palatable food 4 neutral items, we found an activation in the right superior frontal gyrus with BWR as the most important predictor; the lower the BWR (indicative of IUGR), the greater the activation of this region involved in impulse control/decision making facing the viewing of palatable food pictures versus neutral items. At the behavioral level, a general linear model predicting external eating using the DEBQ showed a significant interaction between DHA and IUGR status; in IUGR individuals, the higher the serum DHA, the lower is external eating. In conclusion, we suggest that IUGR moderates brain responses when facing stimuli related to palatable foods, activating an area related to impulse control. Moreover, higher intake of n-3 PUFAs can protect IUGR individuals from developing inappropriate eating behaviors, the putative mechanism of protection would involve decreasing intake in response to external food cues in adolescents/young adults