70 research outputs found
Traveling Poles Elimination Scheme And Calculations Of External Quality Factors Of HOMS In SC Cavities
The main scope of this work is the automation of the extraction procedure of the external quality factors Qext of Higher Order Modes HOMs in Superconducting SC radio frequency RF cavities. The HOMs are generated by charged particle beams traveling through a SC cavity at the speed of light amp; 8776; 1 . The HOMs decay very slowly, depending on localization inside the structure and cell to cell coupling, and may influence succeeding charged particle bunches. Thus it is important, at the SC cavity design optimization stage, to calculate the Qext of HOMs. Traveling Poles Elimination TPE scheme was used to automatically extract Qext from the transmission spectra and careful eigenmode analysis of the SC cavity was performed to confirm TPE results. The eigenmode analysis also delivers important information about band structure, cell to cell coupling and allows rapid identification of modes that could interact with the charged particle bunches
Final design for the bERLinPro main LINAC cavity
The Berlin Energy Recovery Linac Project bERLinPro is designed to develop and demonstrateCWLINAC technology for 100 mA class ERLs. High current operation requires an effective damping of higher order modes HOMs of the 1.3 GHz main linac cavities. We have studied elliptical 7 cell cavities based on a modified Cornell ERL design combined with JLab s waveguide HOM damping approach. This paper will summarize the final optimization of the end cell tuning for minimum external Q of the HOMs, coupler kick calculations of the single TTF fundamental power coupler FPC as well as multipole expansion analysis of the given modes and a discussion on operational aspects
Results and Performance Simulations of the Main Linac Design for BERLinPro
The Berlin Energy Recovery Linac Project BERLinPro is designed to develop and demonstrate CW LINAC technology for 100 mA class ERLs. High current operation requires an effective damping of higher ordermodes HOMs of the 1.3 GHz main linac cavities. We have studied elliptical seven cell cavities damped by five waveguides at the adjacent beam tubes. Eigenmode calculations for geometrical figures of merit show that the present design should allow successful cw linac operation at the maximum beam current of 100 mA 77pC bunch charge. In this paper the progress in HOM calculations to avoid beam breakup instabilities for the favored cavity structure is presente
Evaluation of the role of downregulation of SNF5/INI1 core subunit of SWI/SNF complex in clear cell renal cell carcinoma development
Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene. Additionally, in about 40% of ccRCC cases the mutation in PBRM1 (POLYBROMO1) gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found suggesting potential impairment of this complex function in ccRCC. In this study we assessed the extent to which the core SWI/SNF complex subunit - INI1 (hSNF5/SMARCB1) is affected in ccRCC and whether it has any consequences on the development of this type of cancer. The evaluation of INI1 protein level in samples from 50 patients with diagnosed ccRCC, including three displaying rhabdoid features, showed the INI1 positive staining in rhabdoid cells while the conventional ccRCC cells exhibited reduced INI1 level. This indicated the rhabdoid component of ccRCC as distinct from other known rhabdoid tumors. The reduced INI1 protein level observed in all conventional ccRCC cases used in this study correlated with decreased SMARCB1 gene expression at the transcript level. Consistently, the overexpression of INI1 protein in A498 ccRCC cell line resulted in the elevation of endogenous SMARCB1 transcript level indicating that the INI1-dependent regulatory feedback loop controlling expression of this gene is affected in ccRCC Moreover, the set of INI1 target genes including i.e. CXCL12/CXCR7/CXCR4 chemokine axis was identified to be affected in ccRCC. In summary, we demonstrated that the inactivation of INI1 may be of high importance for ccRCC development and aggressiveness
Highly Unusual Triangular Crystals of Theophylline: The Influence of Solvent on the Growth Rates of Polar Crystal Faces
Anther culture of Lupinus angustifolius: callus formation and the development of multicellular and embryo-like structures
Transcending differences to study the transcendent: an exploratory study of researchers’ and chaplains’ reflections on interdisciplinary spiritual care research collaboration
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