550 research outputs found

    Cervical cancer in women diagnosed at the National Health Laboratory, Sudan: A call for screening

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    Background: Cancer of the cervix is the second most prevalent cancer of women to date in the Sudan, in a concerted review of the records of the hospital-based cancer registry of the Radiation & Isotope Centre of Khartoum (RICK). However, in spite of a wealth of data, this is the first study to date describing the histopathologic prevalence of cervical cancer in the Sudan.Objectives: To identify the percentage and clinicopathological pattern of cervical cancer cases diagnosed at Histopathology Department, National Health Laboratory (NHL) in Khartoum, Sudan.Material and Methods: This is a cross-sectional, descriptive study  conducted at the NHL. All cases with histopathological diagnosis of cervical neoplasm in the period from 2004-2009 were reviewed. Patients’ clinical data were obtained from clinical records. Exclusion criteria included inadequate clinical information and unavailability of both Hematoxylin and Eosin stained (H&E) sections and formalin-fixed paraffin-embedded (FFPE) blocks. The WHO classification of cancer of the cervix (2003) was used to describe disease type. SPSS data analysis was applied.Results: A total of 287 cases were reviewed and 195 cases were included in the study. The mean of cervical cancer cases diagnosed per year at NHL is 7.9%. The commonest age group affected was patients grouped between 41- 60 years (52%) followed by 61-80 years (26.3%). Histologically, 95.9% of the cases were carcinomas. Squamous cell carcinomas were 90.9%, Adenocarcinomas 4.8%, and other epithelial tumours were 4.3%. Of the Squamous carcinomas, 98.8% were invasive and 1.2% intraepithelial (cervical intraepithelial neoplasia). The majority of case presentations were that of a protruding cervical mass. We noticed the commonest symptom being bleeding per vagina.Conclusion: To determine the incidence of cervical cancer in the Sudan a national populationbased registry is necessary. The mean age of patients presenting with cervical cancer to NHL is 53.25 years. This is in keeping with the natural history of the human papilloma virus (HPV). The late presentation of patients with aggressive disease necessitates health  education and cervical cancer screening as well as strict guidelines for medical record keeping in line with good medical practices, enabling good data collection for the newly established population-based cancer registry.Keywords: HPV, invasive squamous cell carcinoma

    Hint for a TeV neutrino emission from the Galactic Ridge with ANTARES

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    Interactions of cosmic ray protons, atomic nuclei, and electrons in the interstellar medium in the inner part of the Milky Way produce a γ-ray flux from the Galactic Ridge. If the γ-ray emission is dominated by proton and nuclei interactions, a neutrino flux comparable to the γ-ray flux is expected from the same sky region.Data collected by the ANTARES neutrino telescope are used to constrain the neutrino flux from the Galactic Ridge in the 1-100 TeV energy range. Neutrino events reconstructed both as tracks and showers are considered in the analysis and the selection is optimized for the search of an excess in the region |ι| < 30°, |b| < 2°. The expected background in the search region is estimated using an off-zone region with similar sky coverage. Neutrino signal originating from a power-law spectrum with spectral index ranging from Τν = 1 to 4 is simulated in both channels. The observed energy distributions are fitted to constrain the neutrino emission from the Ridge.The energy distributions in the signal region are inconsistent with the background expectation at ∼ 96% confidence level. The mild excess over the background is consistent with a neutrino flux with a power law with a spectral index 2.45+0.22-0.34 and a flux normalization dNv/dEv  = 4.0+2.7-2.0 x 1016 GeV−1 cm−2 s−1 sr−1 at 40 TeV reference energy. Such flux is consistent with the expected neutrino signal if the bulk of the observed γ-ray flux from the Galactic Ridge originates from interactions of cosmic ray protons and nuclei with a power-law spectrum extending well into the PeV energy range

    Search for Gamma-Ray and Neutrino Coincidences Using HAWC and ANTARES Data

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    In the quest for high-energy neutrino sources, the Astrophysical Multimessenger Observatory Network has implemented a new search by combining data from the High Altitude Water Cherenkov (HAWC) Observatory and the Astronomy with a Neutrino Telescope and Abyss environmental RESearch (ANTARES) neutrino telescope. Using the same analysis strategy as in a previous detector combination of HAWC and IceCube data, we perform a search for coincidences in HAWC and ANTARES events that are below the threshold for sending public alerts in each individual detector. Data were collected between 2015 July and 2020 February with a live time of 4.39 yr. Over this time period, three coincident events with an estimated false-alarm rate of <1 coincidence per year were found. This number is consistent with background expectations

    All-sky Search for High-Energy Neutrinos from Gravitational Wave Event GW170104 with the ANTARES Neutrino Telescope

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    Advanced LIGO detected a significant gravitational wave signal (GW170104) originating from the coalescence of two black holes during the second observation run on January 4th^{\textrm{th}}, 2017. An all-sky high-energy neutrino follow-up search has been made using data from the ANTARES neutrino telescope, including both upgoing and downgoing events in two separate analyses. No neutrino candidates were found within ±500\pm500 s around the GW event time nor any time clustering of events over an extended time window of ±3\pm3 months. The non-detection is used to constrain isotropic-equivalent high-energy neutrino emission from GW170104 to less than 4×1054\sim4\times 10^{54} erg for a E2E^{-2} spectrum

    The ANTARES Collaboration: Contributions to ICRC 2017 Part I: Neutrino astronomy (diffuse fluxes and point sources)

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    Papers on neutrino astronomy (diffuse fluxes and point sources, prepared for the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the ANTARES Collaboratio

    The ANTARES Collaboration: Contributions to ICRC 2017 Part III: Searches for dark matter and exotics, neutrino oscillations and detector calibration

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    Papers on the searches for dark matter and exotics, neutrino oscillations and detector calibration, prepared for the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the ANTARES Collaboratio

    The ANTARES Collaboration: Contributions to ICRC 2017 Part II: The multi-messenger program

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    Papers on the ANTARES multi-messenger program, prepared for the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the ANTARES Collaboratio

    Infinitesimal sulfur fusion yields quasi-metallic bulk silicon for stable and fast energy storage

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    A fast-charging battery that supplies maximum energy is a key element for vehicle electrification. High-capacity silicon anodes offer a viable alternative to carbonaceous materials, but they are vulnerable to fracture due to large volumetric changes during charge???discharge cycles. The low ionic and electronic transport across the silicon particles limits the charging rate of batteries. Here, as a three-in-one solution for the above issues, we show that small amounts of sulfur doping (<1 at%) render quasi-metallic silicon microparticles by substitutional doping and increase lithium ion conductivity through the flexible and robust self-supporting channels as demonstrated by microscopy observation and theoretical calculations. Such unusual doping characters are enabled by the simultaneous bottom-up assembly of dopants and silicon at the seed level in molten salts medium. This sulfur-doped silicon anode shows highly stable battery cycling at a fast-charging rate with a high energy density beyond those of a commercial standard anode

    Attenuation of Vaccinia Tian Tan Strain by Removal of Viral TC7L-TK2L and TA35R Genes

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    Vaccinia Tian Tan (VTT) was attenuated by deletion of the TC7L-TK2L and TA35R genes to generate MVTT3. The mutant was generated by replacing the open reading frames by a gene encoding enhanced green fluorescent protein (EGFP) flanked by loxP sites. Viruses expressing EGFP were then screened for and purified by serial plaque formation. In a second step the marker EGFP gene was removed by transfecting cells with a plasmid encoding cre recombinase and selecting for viruses that had lost the EGFP phenotype. The MVTT3 mutant was shown to be avirulent and immunogenic. These results support the conclusion that TC7L-TK2L and TA35R deletion mutants can be used as safe viral vectors or as platform for vaccines
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