Seizure characterisation using frequency-dependent multivariate dynamics

The characterisation of epileptic seizures assists in the design of targeted pharmaceutical seizure prevention techniques and pre-surgical evaluations. In this paper, we expand on recent use of multivariate techniques to study the crosscorrelation dynamics between electroencephalographic (EEG) channels. The Maximum Overlap Discrete Wavelet Transform (MODWT) is applied in order to separate the EEG channels into their underlying frequencies. The dynamics of the cross-correlation matrix between channels, at each frequency, are then analysed in terms of the eigenspectrum. By examination of the eigenspectrum, we show that it is possible to identify frequency dependent changes in the correlation structure between channels which may be indicative of seizure activity. The technique is applied to EEG epileptiform data and the results indicate that the correlation dynamics vary over time and frequency, with larger correlations between channels at high frequencies. Additionally, a redistribution of wavelet energy is found, with increased fractional energy demonstrating the relative importance of high frequencies during seizures. Dynamical changes also occur in both correlation and energy at lower frequencies during seizures, suggesting that monitoring frequency dependent correlation structure can characterise changes in EEG signals during these. Future work will involve the study of other large eigenvalues and inter-frequency correlations to determine additional seizure characteristics

On the Effective Description of Large Volume Compactifications

We study the reliability of the Two-Step moduli stabilization in the type-IIB Large Volume Scenarios with matter and gauge interactions. The general analysis is based on a family of N=1 Supergravity models with a factorizable Kaehler invariant function, where the decoupling between two sets of fields without a mass hierarchy is easily understood. For the Large Volume Scenario particular analyses are performed for explicit models, one of such developed for the first time here, finding that the simplified version, where the Dilaton and Complex structure moduli are regarded as frozen by a previous stabilization, is a reliable supersymmetric description whenever the neglected fields stand at their leading F-flatness conditions and be neutral. The terms missed by the simplified approach are either suppressed by powers of the Calabi-Yau volume, or are higher order operators in the matter fields, and then irrelevant for the moduli stabilization rocedure. Although the power of the volume suppressing such corrections depends on the particular model, up to the mass level it is independent of the modular weight for the matter fields. This at least for the models studied here but we give arguments to expect the same in general. These claims are checked through numerical examples. We discuss how the factorizable models present a context where despite the lack of a hierarchy with the supersymmetry breaking scale, the effective theory still has a supersymmetric description. This can be understood from the fact that it is possible to find vanishing solution for the auxiliary components of the fields being integrated out, independently of the remaining dynamics. Our results settle down the question on the reliability of the way the Dilaton and Complex structure are treated in type-IIB compactifications with large compact manifold volumina.Comment: 23 pages + 2 appendices (38 pages total). v2: minor improvements, typos fixed. Version published in JHE

"Big" Divisor D3/D7 Swiss Cheese Phenomenology

We review progress made over the past couple of years in the field of Swiss Cheese Phenomenology involving a mobile space-time filling D3-brane and stack(s) of fluxed D7-branes wrapping the "big" (as opposed to the "small") divisor in (the orientifold of a) Swiss-Cheese Calabi-Yau. The topics reviewed include reconciliation of large volume cosmology and phenomenology, evaluation of soft supersymmetry breaking parameters, one-loop RG-flow equations' solutions for scalar masses, obtaining fermionic (possibly first two generations' quarks/leptons) mass scales in the O(MeV-GeV)-regime as well as (first two generations') neutrino masses (and their one-loop RG flow) of around an eV. The heavy sparticles and the light fermions indicate the possibility of "split SUSY" large volume scenario.Comment: Invited review for MPLA, 14 pages, LaTe

Sequestered Dark Matter

We show that hidden-sector dark matter is a generic feature of the type IIB string theory landscape and that its lifetime may allow for a discovery through the observation of very energetic gamma-rays produced in the decay. Throats or, equivalently, conformally sequestered hidden sectors are common in flux compactifications and the energy deposited in these sectors can be calculated if the reheating temperature of the standard model sector is known. Assuming that throats with various warp factors are available in the compact manifold, we determine which throats maximize the late-time abundance of sequestered dark matter. For such throats, this abundance agrees with cosmological data if the standard model reheating temperature was 10^10 - 10^11 GeV. In two distinct scenarios, the mass of dark matter particles, i.e. the IR scale of the throat, is either around 10^5 GeV or around 10^10 GeV. The lifetime and the decay channels of our dark matter candidates depend crucially on the fact that the Klebanov-Strassler throat is supersymmetric. Furthermore, the details of supersymmetry breaking both in the throat and in the visible sector play an essential role. We identify a number of scenarios where this type of dark matter can be discovered via gamma-ray observations.Comment: 36 pages, 3 figures; v2: references added, v3: introduction extended and typos correcte

The quantification of wind turbulence by means of the fourier dimension

Signal Processing within the frequency domain has long been associated with electrical engineering as a means to quantify the characteristics of voltage/current waveforms. Historically, wind speed data (speed/direction) have been captured and stored as statistical markers within a time series description. This form of storage, while cumbersome, is applicable in wind regimes that are relatively laminar. In urban environments, where the associated topographies and building morphologies are heterogeneous, wind speeds are highly turbulent and chaotic. In such environments and with particular reference to wind energy, time series statistics are of limited use, unless the generic probability distribution function (PDF) is also considered. Furthermore, the industry standard metric that quantifies the turbulent component of wind speed, Turbulence Intensity (TI), is computationally cumbersome and resource intensive. An alternative model to quantify turbulence is proposed here. This paper will describe how Fourier dimension modelling (Df), through linkage with the Weibull probability density function, can quantify turbulence in a more efficient manner. This model could potentially be developed to facilitate urban wind power prediction and is relevant to the planning and development considerations within the built environment

Dark Radiation and Dark Matter in Large Volume Compactifications

We argue that dark radiation is naturally generated from the decay of the overall volume modulus in the LARGE volume scenario. We consider both sequestered and non-sequestered cases, and find that the axionic superpartner of the modulus is produced by the modulus decay and it can account for the dark radiation suggested by observations, while the modulus decay through the Giudice-Masiero term gives the dominant contribution to the total decay rate. In the sequestered case, the lightest supersymmetric particles produced by the modulus decay can naturally account for the observed dark matter density. In the non-sequestered case, on the other hand, the supersymmetric particles are not produced by the modulus decay, since the soft masses are of order the heavy gravitino mass. The QCD axion will then be a plausible dark matter candidate.Comment: 27 pages, 4 figures; version 3: version published in JHE

Wavefunctions and the Point of E8 in F-theory

In F-theory GUTs interactions between fields are typically localised at points of enhanced symmetry in the internal dimensions implying that the coefficient of the associated operator can be studied using a local wavefunctions overlap calculation. Some F-theory SU(5) GUT theories may exhibit a maximum symmetry enhancement at a point to E8, and in this case all the operators of the theory can be associated to the same point. We take initial steps towards the study of operators in such theories. We calculate wavefunctions and their overlaps around a general point of enhancement and establish constraints on the local form of the fluxes. We then apply the general results to a simple model at a point of E8 enhancement and calculate some example operators such as Yukawa couplings and dimension-five couplings that can lead to proton decay.Comment: 46 page

The critical window for the classical Ramsey-Tur\'an problem

The first application of Szemer\'edi's powerful regularity method was the following celebrated Ramsey-Tur\'an result proved by Szemer\'edi in 1972: any K_4-free graph on N vertices with independence number o(N) has at most (1/8 + o(1)) N^2 edges. Four years later, Bollob\'as and Erd\H{o}s gave a surprising geometric construction, utilizing the isoperimetric inequality for the high dimensional sphere, of a K_4-free graph on N vertices with independence number o(N) and (1/8 - o(1)) N^2 edges. Starting with Bollob\'as and Erd\H{o}s in 1976, several problems have been asked on estimating the minimum possible independence number in the critical window, when the number of edges is about N^2 / 8. These problems have received considerable attention and remained one of the main open problems in this area. In this paper, we give nearly best-possible bounds, solving the various open problems concerning this critical window.Comment: 34 page

Lactobacillus fermentum (PCC®) supplementation and gastrointestinal and respiratory-tract illness symptoms: a randomised control trial in athletes

BACKGROUND Probiotics purportedly reduce symptoms of gastrointestinal and upper respiratory-tract illness by modulating commensal microflora. Preventing and reducing symptoms of respiratory and gastrointestinal illness are the primary reason that dietary supplementation with probiotics are becoming increasingly popular with healthy active individuals. There is a paucity of data regarding the effectiveness of probiotics in this cohort. The aim of this study was to evaluate the effectiveness of a probiotic on faecal microbiology, self-reported illness symptoms and immunity in healthy well trained individuals. METHODS Competitive cyclists (64 males and 35 females; age 35 ± 9 and 36 ± 9 y, VO2max 56 ± 6 and 52 ± 6 ml.kg-1.min-1, mean ± SD) were randomised to either probiotic (minimum 1 × 109 Lactobacillus fermentum (PCC®) per day) or placebo treatment for 11 weeks in a double-blind, randomised, controlled trial. The outcome measures were faecal L. fermentum counts, self-reported symptoms of illness and serum cytokines. RESULTS Lactobacillus numbers increased 7.7-fold (90% confidence limits 2.1- to 28-fold) more in males on the probiotic, while there was an unclear 2.2-fold (0.2- to 18-fold) increase in females taking the probiotic. The number and duration of mild gastrointestinal symptoms were ~2-fold greater in the probiotic group. However, there was a substantial 0.7 (0.2 to 1.2) of a scale step reduction in the severity of gastrointestinal illness at the mean training load in males, which became more pronounced as training load increased. The load (duration×severity) of lower respiratory illness symptoms was less by a factor of 0.31 (99%CI; 0.07 to 0.96) in males taking the probiotic compared with placebo but increased by a factor of 2.2 (0.41 to 27) in females. Differences in use of cold and flu medication mirrored these symptoms. The observed effects on URTI had too much uncertainty for a decisive outcome. There were clear reductions in the magnitude of acute exercise-induced changes in some cytokines. CONCLUSION L. fermentum may be a useful nutritional adjunct for healthy exercising males. However, uncertainty in the effects of supplementation on URTI and on symptoms in females needs to be resolved. TRIAL REGISTRATION The trial was registered in the Australia and New Zealand Clinical Trials Registry (ACTRN12611000006943).The study was funded by Christian Hansen A/S, Probiomics and the Australian Institute of Sport

On 'Light' Fermions and Proton Stability in 'Big Divisor' D3/D7 Swiss Cheese Phenomenology

Building up on our earlier work [1,2], we show the possibility of generating "light" fermion mass scales of MeV-GeV range (possibly related to first two generations of quarks/leptons) as well as eV (possibly related to first two generations of neutrinos) in type IIB string theory compactified on Swiss-Cheese orientifolds in the presence of a mobile space-time filling D3-$brane restricted to (in principle) stacks of fluxed D7-branes wrapping the "big" divisor \Sigma_B. This part of the paper is an expanded version of the latter half of section 3 of a published short invited review [3] written up by one of the authors [AM]. Further, we also show that there are no SUSY GUT-type dimension-five operators corresponding to proton decay, as well as estimate the proton lifetime from a SUSY GUT-type four-fermion dimension-six operator to be 10^{61} years. Based on GLSM calculations in [1] for obtaining the geometric Kaehler potential for the "big divisor", using further the Donaldson's algorithm, we also briefly discuss in the first of the two appendices, obtaining a metric for the Swiss-Cheese Calabi-Yau used, that becomes Ricci flat in the large volume limit.Comment: v2: 1+25 pages, Title modified and text thoroughly expanded including a brief discussion on obtaining Ricci-flat Swiss Cheese Calabi-Yau metrics using the Donaldson's algorithm, references added, to appear in EPJ