Influence of Fillers on the Properties of the Composite Sulfur-Containing Material

Секция III : Ресурсо- и энергосберегающие строительные материалы и технологииРассмотрен вопрос утилизации отходов камнеобработки в Республике Беларусь и применение гранитных отсевов в качестве заполнителей для создания композиционных материалов, изготовленных на основе серы. Приведены экспериментальные данные по исследованию физико-механических свойств серного бетона, таких как прочность и водопоглощение, в зависимости от количества серы, песка и гранитных отсевов, образующихся на РУПП «Гранит». Сделаны выводы о влиянии гранитных отсевов на свойства серного бетона.=The issue of utilization of stone processing wastes in the Republic of Belarus and the use of granite screenings as aggregates for the creation of sulfur-based composite materials are considered. Experimental data on the physical and mechanical properties of sulfur concrete, such as strength and water absorption, are given, depending on the amount of sulfur, sand and granite screenings formed at the Granit RUPP. Conclusions are drawn about the effect of granite screenings on the properties of sulfur concrete

Influence of Fillers on the Properties of the Composite Sulfur-Containing Material

Секция III : Ресурсо- и энергосберегающие строительные материалы и технологииРассмотрен вопрос утилизации отходов камнеобработки в Республике Беларусь и применение гранитных отсевов в качестве заполнителей для создания композиционных материалов, изготовленных на основе серы. Приведены экспериментальные данные по исследованию физико-механических свойств серного бетона, таких как прочность и водопоглощение, в зависимости от количества серы, песка и гранитных отсевов, образующихся на РУПП «Гранит». Сделаны выводы о влиянии гранитных отсевов на свойства серного бетона.=The issue of utilization of stone processing wastes in the Republic of Belarus and the use of granite screenings as aggregates for the creation of sulfur-based composite materials are considered. Experimental data on the physical and mechanical properties of sulfur concrete, such as strength and water absorption, are given, depending on the amount of sulfur, sand and granite screenings formed at the Granit RUPP. Conclusions are drawn about the effect of granite screenings on the properties of sulfur concrete

Glycosylation of Erythrocyte Spectrin and Its Modification in Visceral Leishmaniasis

Using a lectin, Achatinin-H, having preferential specificity for glycoproteins with terminal 9-O-acetyl sialic acid derivatives linked in α2-6 linkages to subterminal N-acetylgalactosamine, eight distinct disease-associated 9-O-acetylated sialoglycoproteins was purified from erythrocytes of visceral leishmaniaisis (VL) patients (RBCVL). Analyses of tryptic fragments by mass spectrometry led to the identification of two high-molecular weight 9-O-acetylated sialoglycoproteins as human erythrocytic α- and β-spectrin. Total spectrin purified from erythrocytes of VL patients (spectrinVL) was reactive with Achatinin-H. Interestingly, along with two high molecular weight bands corresponding to α- and β-spectrin another low molecular weight 60 kDa band was observed. Total spectrin was also purified from normal human erythrocytes (spectrinN) and insignificant binding with Achatinin-H was demonstrated. Additionally, this 60 kDa fragment was totally absent in spectrinN. Although the presence of both N- and O-glycosylations was found both in spectrinN and spectrinVL, enhanced sialylation was predominantly induced in spectrinVL. Sialic acids accounted for approximately 1.25 kDa mass of the 60 kDa polypeptide. The demonstration of a few identified sialylated tryptic fragments of α- and β-spectrinVL confirmed the presence of terminal sialic acids. Molecular modelling studies of spectrin suggest that a sugar moiety can fit into the potential glycosylation sites. Interestingly, highly sialylated spectrinVL showed decreased binding with spectrin-depleted inside-out membrane vesicles of normal erythrocytes compared to spectrinN suggesting functional abnormality. Taken together this is the first report of glycosylated eythrocytic spectrin in normal erythrocytes and its enhanced sialylation in RBCVL. The enhanced sialylation of this cytoskeleton protein is possibly related to the fragmentation of spectrinVL as evidenced by the presence of an additional 60 kDa fragment, absent in spectrinN which possibly affects the biology of RBCVL linked to both severe distortion of erythrocyte development and impairment of erythrocyte membrane integrity and may provide an explanation for their sensitivity to hemolysis and anemia in VL patients

Mechanisms Underlaying Regulation of Synaptic Transmission in Hippocampus by Hydrogen Peroxide

Latest findings provided evidences of the important role of reactive oxygen species in cellular signal processes. In this study we examined the action of hydrogen peroxide on synaptic transmission in the hippocampus. Millimolar concentrations of hydrogen peroxide decreased fEPSP amplitude evoked in the CA1 region of rat hippocampal slices. GABAA receptors antagonist picrotoxin, ryanodine receptors antagonist dantrolene, ATP-sensitive potassium channels antagonist tolbutamide had no influence on the inhibitory effect of hydrogen peroxide whereas non-specific adenosine receptors antagonist caffeine blocked fEPSP depression by hydrogen peroxide, indicating that synaptic transmission inhibition involved adenosine receptors activation. Pretreatment of slices with hydrogen peroxide before the addition of adenosine had no effect on the fEPSP depression caused by adenosine suggesting that functional properties of adenosine receptors are not affected by hydrogen peroxide

Mechanisms Underlaying Regulation of Synaptic Transmission in Hippocampus by Hydrogen Peroxide

Latest findings provided evidences of the important role of reactive oxygen species in cellular signal processes. In this study we examined the action of hydrogen peroxide on synaptic transmission in the hippocampus. Millimolar concentrations of hydrogen peroxide decreased fEPSP amplitude evoked in the CA1 region of rat hippocampal slices. GABAA receptors antagonist picrotoxin, ryanodine receptors antagonist dantrolene, ATP-sensitive potassium channels antagonist tolbutamide had no influence on the inhibitory effect of hydrogen peroxide whereas non-specific adenosine receptors antagonist caffeine blocked fEPSP depression by hydrogen peroxide, indicating that synaptic transmission inhibition involved adenosine receptors activation. Pretreatment of slices with hydrogen peroxide before the addition of adenosine had no effect on the fEPSP depression caused by adenosine suggesting that functional properties of adenosine receptors are not affected by hydrogen peroxide

Multichannel system for recording of neuronal electrical activity in vitro

Методы и аппаратура для научных исследовани

Patterns of electrical activity generated by biological neural network in vitro

Cultured dissociated neurons forming network in vitro is a unique system representing living biological neural net- work developing in fully artificial conditions. This is a promising model for study of basic mechanisms of the brain functioning that requires special tools for interfacing and investigations. We have developed a set of devices and techniques for culturing of neural network on the surface of microelectrode sensor and registered specific patterns of electrical activity of the living neural network in vitro

Competitive learning in neural network under neuromodulatory influences

Биофизика клеточных процессов и клеточные технологи

Competitive learning in neural network under neuromodulatory influences

Биофизика клеточных процессов и клеточные технологи

Metastable Al\u2013Si\u2013Ni alloys for additive manufacturing: Structural stability and energy release during heating

Rapid solidification with high cooling rates of metal alloys determines both the improvement of mechanical properties, due to the finishing of the structure, as well as obtaining metastable structures in the form of supersaturated or amorphous/nano solid solutions, which could potentially confer the material outstanding properties. It is of particular interest to use the energies released during the heating stage for these materials, due to the potentially lower input energy required to melt/fuse these materials. This phenomenon could add to the development and diversification of additive manufacturing technologies. The paper presents results concerning the structural development and phase transformation of metastable structures from Al\u2013Si\u2013Ni-based alloys, obtained by melt spinning and atomization techniques. It was observed that the structural transformations occurring during the heating process, starting from metastable structures, generate significant amounts of energy. This is of practical importance in the use of metallic powders in additive manufacturing technology, due to potentially reduced energy input