1,861 research outputs found
Expression of Rb2/p130 in breast and endometrial cancer: correlations with hormone receptor status
Rb2/p130 is a member of the retinoblastoma family of proteins, consisting of Rb, Rb2 and p107, which are important negative regulators of cell cycle progression and differentiation. While Rb2 downregulation was observed in several malignant tumours including endometrial cancer, the role of p130 in breast carcinomas is still unknown. We investigated Rb2 protein expression in tumour tissue from 68 mammary and 41 endometrial carcinomas, 4 mammary cell lines, and normal tissue samples. Therefore, we performed Western blot experiments for Rb2, Rb, and the oestrogen and progesterone receptors (ER, PR-A, PR-B). Weak or absent Rb2 expression was more often found in endometrial (59%) than in mammary carcinomas (24%). We found significant positive correlations of Rb2 expression with Rb, ER, and PR-B in breast cancer samples, and of Rb2 with Rb, PR-A, PR-B, and younger age in endometrial carcinomas. No significant associations with histological grading, stage, nodal involvement, or Ki67 staining were detected. Rb2 mRNA expression was studied by semi-quantitative RT-PCR in 56 endometrial or mammary tissue samples and correlated significantly with Western blot results. Our results indicate that loss of Rb2 expression, mostly by transcriptional down-regulation, may be associated with the development and dedifferentiation of most endometrial and a subset of mammary carcinomas. © 2001 Cancer Research Campaign http://bjcancer.co
Correlation measurements in high-multiplicity events
Requirements for correlation measurements in high--multiplicity events are
discussed. Attention is focussed on detection of so--called hot spots,
two--particle rapidity correlations, two--particle momentum correlations (for
quantum interferometry) and higher--order correlations. The signal--to--noise
ratio may become large in the high--multiplicity limit, allowing meaningful
single--event measurements, only if the correlations are due to collective
behavior.Comment: MN 55455, 20 pages, KSUCNR-011-92 and TPI-MINN-92/47-T (revised).
Revised to correct typo in equation (30), and to fill in a few steps in
calculations. Now published as Phys. Rev. C 47 (1993) 232
suppression in Pb+Pb collisions and broadening
We have analysed the NA50 data, on the centrality dependence of
broadening of 's, in Pb+Pb collisions, at the CERN-SPS. The data were
analysed in a QCD based model, where 's are suppressed in 'nuclear'
medium. Without any free parameter, the model could explain the NA50
broadening data. The data were also analysed in a QGP based threshold model,
where suppression is 100% above a critical density. The QGP based
model could not explain the NA50 broadening data. We have also predicted
the centrality dependence of suppression and broadening at RHIC
energy. Both the models, the QGP based threshold model and the QCD based
nuclear absorption model, predict broadening very close to each other.Comment: The paper was completely revised. The conclusion is also changed. 5
pages, 4 figure
Testing the Resolving Power of 2-D K^+ K^+ Interferometry
Adopting a procedure previously proposed to quantitatively study
two-dimensional pion interferometry, an equivalent 2-D chi^2 analysis was
performed to test the resolving power of that method when applied to less
favorable conditions, i.e., if no significant contribution from long lived
resonances is expected, as in kaon interferometry. For that purpose, use is
made of the preliminary E859 K^+ K^+ interferometry data from Si+Au collisions
at 14.6 AGeV/c. As expected, less sensitivity is achieved in the present case,
although it still is possible to distinguish two distinct decoupling
geometries. The present analysis seems to favor scenarios with no resonance
formation at the AGS energy range, if the preliminary K^+ K^+ data are
confirmed. The possible compatibility of data with zero decoupling proper time
interval, conjectured by the 3-D experimental analysis, is also investigated
and is ruled out when considering more realistic dynamical models with
expanding sources. These results, however, clearly evidence the important
influence of the time emission interval on the source effective transverse
dimensions. Furthermore, they strongly emphasize that the static Gaussian
parameterization, commonly used to fit data, cannot be trusted under more
realistic conditions, leading to distorted or even wrong interpretation of the
source parameters!Comment: 11 pages, RevTeX, 4 Postscript figures include
Thermal phenomenology of hadrons from 200 AGeV S+S collisions
We develop a complete and consistent description for the hadron spectra from
heavy ion collisions in terms of a few collective variables, in particular
temperature, longitudinal and transverse flow. To achieve a meaningful
comparison with presently available data, we also include the resonance decays
into our picture. To disentangle the influences of transverse flow and
resonance decays in the -spectra, we analyse in detail the shape of the
-spectra.Comment: 31 pages, 13 figs in seperate uuencoded file, for LaTeX, epsf.sty and
dvips, TPR-93-16 and BNL-(no number yet
Hydrodynamical assessment of 200 AGeV collisions
We are analyzing the hydrodynamics of 200 A GeV S+S collisions using a new
approach which tries to quantify the uncertainties arising from the specific
implementation of the hydrodynamical model. Based on a previous
phenomenological analysis we use the global hydrodynamics model to show that
the amount of initial flow, or initial energy density, cannot be determined
from the hadronic momentum spectra. We additionally find that almost always a
sizeable transverse flow deve- lops, which causes the system to freeze out,
thereby limiting the flow velocity in itself. This freeze-out dominance in turn
makes a distinction between a plasma and a hadron resonance gas equation of
state very difficult, whereas a pure pion gas can easily be ruled out from
present data. To complete the picture we also analyze particle multiplicity
data, which suggest that chemical equilibrium is not reached with respect to
the strange particles. However, the over- population of pions seems to be at
most moderate, with a pion chemical potential far away from the Bose
divergence.Comment: 19 pages, 11 figs in separate uuencoded file, for LateX, epsf.tex,
dvips, TPR-94-5 and BNL-(no number yet
The ZEUS Forward Plug Calorimeter with Lead-Scintillator Plates and WLS Fiber Readout
A Forward Plug Calorimeter (FPC) for the ZEUS detector at HERA has been built
as a shashlik lead-scintillator calorimeter with wave length shifter fiber
readout. Before installation it was tested and calibrated using the X5 test
beam facility of the SPS accelerator at CERN. Electron, muon and pion beams in
the momentum range of 10 to 100 GeV/c were used. Results of these measurements
are presented as well as a calibration monitoring system based on a Co
source.Comment: 38 pages (Latex); 26 figures (ps
Signaling in Secret: Pay-for-Performance and the Incentive and Sorting Effects of Pay Secrecy
Key Findings: Pay secrecy adversely impacts individual task performance because it weakens the perception that an increase in performance will be accompanied by increase in pay; Pay secrecy is associated with a decrease in employee performance and retention in pay-for-performance systems, which measure performance using relative (i.e., peer-ranked) criteria rather than an absolute scale (see Figure 2 on page 5); High performing employees tend to be most sensitive to negative pay-for- performance perceptions; There are many signals embedded within HR policies and practices, which can influence employees’ perception of workplace uncertainty/inequity and impact their performance and turnover intentions; and When pay transparency is impractical, organizations may benefit from introducing partial pay openness to mitigate these effects on employee performance and retention
Constraints on new interactions from neutron scattering experiments
Constraints for the constants of hypothetical Yukawa-type corrections to the
Newtonian gravitational potential are obtained from analysis of neutron
scattering experiments. Restrictions are obtained for the interaction range
between 10^{-12} and 10^{-7} cm, where Casimir force experiments and atomic
force microscopy are not sensitive. Experimental limits are obtained also for
non-electromagnetic inverse power law neutron-nucleus potential. Some
possibilities are discussed to strengthen these constraints.Comment: 18 pages, 3 figure
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