Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

Over eight different families of natural products, consisting of nearly seventy secondary metabolites, which contain the bicyclo[2.2.2]diazaoctane ring system, have been isolated from various Aspergillus, Penicillium, and Malbranchea species. Since 1968, these secondary metabolites have been the focus of numerous biogenetic, synthetic, taxonomic, and biological studies, and, as such, have made a lasting impact across multiple scientific disciplines. This review covers the isolation, biosynthesis, and biological activity of these unique secondary metabolites containing the bridging bicyclo[2.2.2]diazaoctane ring system. Furthermore, the diverse fungal origin of these natural products is closely examined and, in many cases, updated to reflect the currently accepted fungal taxonomy

Intestinal mucosa anti-transglutaminase antibodies in early stage of gluten intolerance

9nonenoneZIBERNA F; BALDAS V; MARTELOSSI S; VILLANACCI V; MARZARI R; FLORIAN F; VATTA S; VENTURA A; NOT T.Ziberna, F; Baldas, V; Martelossi, S; Villanacci, V; Marzari, R; Florian, Fiorella; Vatta, S; Ventura, Alessandro; Not, Tarcisi

Human recombinat alfa-enolase antibodies in celiac disease and in other auto-immune diseases

8nonenoneBaldas V; Edomi P; Cortini A; Ziberna F; Azzoni E; Liciulli M; Ferrara F; Not TBaldas, V; Edomi, Paolo; Cortini, A; Ziberna, F; Azzoni, E; Liciulli, M; Ferrara, F; Not, Tarcisi

Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies.

The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac

The analysis of the fine specificity of celiac disease antibodies using tissue transglutaminase fragments

Celiac disease is an intestinal malabsorption characterized by an intolerance to cereal proteins accompanied by immunological responses to dietary gliadins and an autoantigen located in the endomysium. The latter has been identified as the enzyme tissue transglutaminase which belongs to a family of enzymes that catalyze protein cross-linking reactions and is constitutively expressed in many tissues as well as being activated during apoptosis. In a recent paper, we described the selection and characterization of anti-transglutaminase Igs from phage antibody libraries created from intestinal lymphocytes from celiac disease patients. In this work, using transglutaminase gene fragments, we identify a region of tissue transglutaminase recognized by these antibodies as being conformational and located in the core domain of the enzyme. This is identical to the region recognized by anti-transglutaminase Igs found in the serum of celiac disease patients

MBL2 gene, another genetic factor, different from HLA, influencing coeliac disease?

8nonenoneBaldas V; Taddio A; Antonopoulou M; Trevisiol C; Berti I; Percopo S; Crovella S; Not TBaldas, V; Taddio, Andrea; Antonopoulou, M; Trevisiol, C; Berti, I; Percopo, S; Crovella, Sergio; Not, Tarcisi