3 research outputs found
Diverse Bone Morphogenetic Protein Expression Profiles and Smad Pathway Activation in Different Phenotypes of Experimental Canine Mammary Tumors
- Author
- A Franzen
- A Moustakas
- A von Bubnoff
- E Hellmen
- E Hellmen
- EL Alarmo
- EL Alarmo
- Eva Hellmén
- F Kugimiya
- F Pouliot
- Gunnar Pejler
- H Chang
- H Cheng
- H Wensman
- H Yoshikawa
- Helena Wensman
- J Du
- J Kononen
- J Pratap
- J Sammons
- JA Jane Jr
- JM Wozney
- K Andreev
- K Tamaki
- KS Kraunz
- L Attisano
- MS Friedman
- MW Helms
- N Nakayama
- NE Heldin
- Nils-Erik Heldin
- Patrick Callaerts
- Q Kang
- S Tateyama
- T Akiyoshi
- T Baade Ro
- U Persson
- W Misdorp
- Publication venue
- Public Library of Science
- Publication date
- 01/09/2009
- Field of study
BACKGROUND:BMPs are currently receiving attention for their role in tumorigenesis and tumor progression. Currently, most BMP expression studies are performed on carcinomas, and not much is known about the situation in sarcomas. METHODOLOGY/PRINCIPAL FINDINGS:We have investigated the BMP expression profiles and Smad activation in clones from different spontaneous canine mammary tumors. Spindle cell tumor and osteosarcoma clones expressed high levels of BMPs, in particular BMP-2, -4 and -6. Clones from a scirrhous carcinoma expressed much lower BMP levels. The various clones formed different tumor types in nude mice but only clones that expressed high levels of BMP-6 gave bone formation. Phosphorylated Smad-1/5, located in the nucleus, was detected in tumors derived from clones expressing high levels of BMPs, indicating an active BMP signaling pathway and BMP-2 stimulation of mammary tumor cell clones in vitro resulted in activation of the Smad-1/5 pathway. In contrast BMP-2 stimulation did not induce phosphorylation of the non-Smad pathway p38 MAPK. Interestingly, an increased level of the BMP-antagonist chordin-like 1 was detected after BMP stimulation of non-bone forming clones. CONCLUSIONS/SIGNIFICANCE:We conclude that the specific BMP expression repertoire differs substantially between different types of mammary tumors and that BMP-6 expression most probably has a biological role in bone formation of canine mammary tumors
Prostatakarzinom
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- A. Berruti
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- A. Bill-Axelson
- A. Bill-Axelson
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- A. Briganti
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- A. Jemal
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- S.J. Freedland
- S.J. Freedland
- S.J. Freedland
- S.J. Freedland
- S.J. Mistry
- S.K. Clinton
- S.K. Quella
- S.L. Goldenberg
- S.L. Goldenberg
- S.L. Zheng
- S.M. Dhanasekaran
- S.M. Harman
- S.M. Lesko
- S.O. Andersson
- S.O. Andersson
- S.O. Vargas
- S.R. Potter
- S.S. Coughlin
- S.V. Tavtigian
- T. A. Stamey
- T. Björk
- T. Eggert
- T. Eichenberger
- T. Granfors
- T. Hara
- T. J. McDonnell
- T. Kanda
- T. Kato
- T. Kitamura
- T. Krupski
- T. Loch
- T. Loch
- T. Loch
- T. Loch
- T. M. Beer
- T. Otto
- T. Prayer-Galetti
- T. Schlomm
- T. Schlomm
- T. Schlomm
- T. Sella
- T. Tarcan
- T. Visakorpi
- T. Wiegel
- T.A. Stamey
- T.E. Ahlering
- T.H. Diamond
- T.H. Kwast Van der
- T.I. Lund Nilsen
- T.J. Hartman
- T.J. Key
- T.J. Maatman
- T.J. Polascik
- T.J. Sebo
- T.L. Griebling
- T.L. Randolph
- T.M. Koppie
- T.M. Vogt
- T.M. Vogt
- T.M. Wheeler
- U. Ganswindt
- U. Zwergel
- U.E. Studer
- U.H. Stenman
- U.H. Stenman
- U.W. Tunn
- UICC
- V. Ravery
- V. Scattoni
- V.B. Shahinian
- V.E. Weldon
- Veterans Administration Cooperative Urological Research Group VACURG)
- Veterans Administration Cooperative Urological Research Group VACURG)
- W. D. Figg
- W. Haenszel
- W. K. Kelly
- W. K. Kelly
- W. K. Oh
- W. L. Dahut
- W. See
- W. Stahl
- W.A. Sakr
- W.B. Grant
- W.H. Cooner
- W.H. Pinover
- W.J. Catalona
- W.J. Catalona
- W.J. Catalona
- W.J. Catalona
- W.J. Catalona
- W.J. Catalona
- W.J. Catalona
- W.J. Catalona
- W.J. Catalona
- W.J. Ellis
- W.J. Ellis
- W.K. Ellis
- W.K. Lau
- W.K. Oh
- W.L. Strohmaier
- W.R. Lee
- W.U. Shipley
- W.W. Roberts
- W.W. Scott
- W.W. Scott
- X. Rebillard
- Y. Kojima
- Y.P. Yu
- Z. Fuks
- Z. Korodi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Prostatakarzinom
- Author
- A Auvinen
- A Bamias
- A Berruti
- A Bhandari
- A Bill-Axelson
- A Bill-Axelson
- A Bill-Axelson
- A Briganti
- A Briganti
- A Briganti
- A Brufsky
- A Buness
- A Falcone
- A Farkas
- A Fleischmann
- A Gelet
- A Gelet
- A Gelet
- A Haese
- A Haese
- A Heidenreich
- A Heidenreich
- A Heidenreich
- A Heidenreich
- A Hoogendam
- A Hsu
- A Jemal
- A Jemal
- A Jemal
- A Jemal
- A Jemal
- A Kasraeian
- A Kumar
- A L Potosky
- A Lipton
- A Lopez-Beltran
- A Magheli
- A Nomura
- A Pollack
- A Prando
- A R Golshayan
- A Radu
- A Rokman
- A Salonia
- A Semjonow
- A Serpa Neto
- A Stein
- A Tavani
- A V Kaisary
- A Vaidya
- A Zambrano
- AA Renshaw
- AA Renshaw
- AB Jani
- AC Thorpe
- AD Merrilees
- AD Vassil
- AE Norrish
- AE Norrish
- AF Chambers
- AG Schuurman
- AG Schuurman
- AG Schuurman
- AH Horan
- AJ Stephenson
- AJ Stephenson
- AJ Stephenson
- AJ Stephenson
- AJ Stephenson
- AJ Stephenson
- AJ Vickers
- AJ Vickers
- AJ Vickers
- AJ Vickers
- AK Leventis
- AK Williams
- AL Hanlon
- AL Potosky
- AL Potosky
- AL Zietman
- AM Kamat
- AM Lavoipierre
- AM Nomura
- AM Nomura
- AM Nomura
- AM Nomura
- AM Wise
- Anon
- AP Berger
- AP Dicker
- AP Polednak
- AR Kristal
- AR Kristal
- AR Kristal
- AR Ramsden
- AR Sgrignoli
- AS Whittemore
- AS Whittemore
- AU Onder
- AV D’Amico
- AV D’Amico
- AV D’Amico
- AV D’Amico
- AV D’Amico
- AV Parwani
- AW Hsing
- AW Hsing
- AW Hsing
- AW Hsing
- AW Hsing
- AW Mazur
- AW Partin
- AW Partin
- AW Partin
- AW Partin
- AW Partin
- AW Partin
- AW Partin
- B Armstrong
- B Candas
- B Djavan
- B Djavan
- B Gowardhan
- B Helpap
- B Helpap
- B Helpap
- B Hoppe
- B Shekarriz
- BA Mohr
- BA Verhage
- Benson De La Taille A
- BF Hankey
- BL Lokeshwar
- BL Pfeifer
- BS Carter
- BS Carter
- BS Garra
- C Boergermann
- C Borgermann
- C Buonerba
- C Gosselaar
- C Hofer
- C Hofer
- C Huggins
- C Iehle
- C J Tyrrell
- C J Tyrrell
- C Loebke
- C Maramag
- C Mettlin
- C Morrissey
- C P Wu
- C Parker
- C Parker
- C Rodriguez
- C Rodriguez
- C S Higano
- C Stephan
- C Stephan
- C Stephan
- C Tran
- CA Carter
- CA Mawson
- CB Begg
- CD Chen
- CD Danila
- CD Taylor
- CG Ramos
- CG Roehrborn
- CG Roehrborn
- CH Bangma
- CH Bangma
- CH Bock
- CH Chang
- CH Chang
- CI Sartor
- CJ Beard
- CJ Diblasio
- CJ Kane
- CJ Luscombe
- CJ Mettlin
- CJ Rosser
- CJ Ryan
- CJ Ryan
- CJ Ryan
- CJ Ryan
- CJ Tyrrell
- CK Osborne
- CL Hsieh
- CM Coley
- CP Price
- CP Price
- CR Mitchell
- CR Pound
- CR Pound
- CU Jones
- CV Smith
- D Albanes
- D Amsellem-Ouazana
- D Das
- D Davidson
- D G McLeod
- D G McLeod
- D Hanahan
- D Hessels
- D Hirano
- D Ilic
- D J
- D J Samson
- D K Wysowski
- D Kritchevsky
- D Leibovici
- D Leibovici
- D McLeod
- D P Byar
- D Schilling
- D Weckermann
- D Woodrum
- D Yang
- DA Kuban
- DA Kuban
- DB Agus
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- DC Beyer
- DC Beyer
- DC Chade
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- DC Danila
- DC Smith
- DC Smith
- DC Smith
- den Bergh RC van
- den Ouden D van
- der Kwast TH Van
- der Poel HG van
- DF Easton
- DF Gleason
- DI Quinn
- DI Quinn
- DJ Grignon
- DJ McLernon
- DJ Schaid
- DJ Schaid
- DK Bahn
- DK Ornstein
- DL Longo
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- DP Petrylak
- DP Petrylak
- DP Petrylak
- DP Rose
- DR Berthold
- DR Mador
- DR Shaffer
- DS Ellis
- DS Elterman
- DS Michaud
- DS Smith
- DS Yee
- DW Keetch
- E Barrett-Connor
- E Ben-Josef
- E Fricke
- E Fricke
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Leifke
- E Lonn
- E P Gelmann
- E Rogers
- E Sala
- E Zacharakis
- EA Klein
- EA Ostrander
- EA Platz
- EA Platz
- EA Platz
- EB Silberstein
- ED Cook
- EE Calle
- EH Cooner
- EH Corder
- EH Seppala
- EJ Fox
- EJ Halpern
- EJ Small
- EJ Small
- EJ Small
- EJ Trabulsi
- EL Gheiler
- EM Conlon
- EM John
- EM Lange
- EM Messing
- EM Messing
- ES Guns
- EY Yu
- F Akyol
- F Ataman
- F Azzouni
- F Boccardo
- F Boccardo
- F De Conno
- F Demichelis
- F E Calais da Silva
- F H Schroder
- F Haller
- F Labrie
- F Labrie
- F Oberpenning
- F Peinemann
- F Rozhansky
- F Wawroschek
- F Wiklund
- FA Critz
- FC Fervenza
- FE Glover Jr
- FE Glover Jr
- FE Kuehhas
- FH Schroder
- FH Schroder
- FH Schroder
- FH Schroder
- FH Schroder
- FH Schröder
- FH Schröder
- FH Schröder
- Fierro L De Stefani E
- FJ Bianco Jr.
- FK Chun
- FK Chun
- FKH Chun
- FL Crowe
- FR Schroeck
- G A Viani
- G Andriole
- G Attard
- G Aus
- G Aus
- G Aus
- G Blackledge
- G Borghede
- G Cancel-Tassin
- G Di Lorenzo
- G Draisma
- G Giannarini
- G Giovacchini
- G Giovacchini
- G Giovacchini
- G Gong
- G J Kolvenbag
- G J Kolvenbag
- G L Shaw
- G Morganti
- G Salomon
- G Schubert-Fritschle
- G Severi
- G Soletormos
- G Vallancien
- GA Hawkins
- GC Morton
- GD Grossfeld
- GD Steinberg
- GE Ayala
- GF Carvalhal
- GF Carvalhal
- GG Giles
- GJ Cook
- GJ Kolvenbag
- GJ Neerhut
- GJ Netto
- GK Zagars
- GL Andriole
- GL Andriole
- GL Andriole
- GL Grado
- GL Lu-Yao
- GT Bales
- GV Raj
- GW Comstock
- GW Hull
- H Akaza
- H Augustin
- H Augustin
- H Augustin
- H Baumert
- H Gronberg
- H Hricak
- H J Voogt de
- H Koh
- H Lepor
- H Lepor
- H Lepor
- H Lepor
- H Li
- H Lilja
- H Lilja
- H Lilja
- H Lilja
- H Loertzer
- H Luboldt
- H Miyake
- H Nakanishi
- H Nakanishi
- H Poppel Van
- H Rennert
- H Sies
- H Van Poppel
- H Wang
- H Yu
- H Yu
- H Yu
- H Zhu
- H. Zincke
- HA Guess
- HA van Vugt
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HB Carter
- HD Strickler
- HG FrohmĂĽller
- HG Sim
- HI Scher
- HI Scher
- HJ Luboldt
- HJ Luboldt
- HJ Thompson
- HM Nagler
- HO Adami
- HP Schmid
- HS Clarke Jr.
- Hsing AW Hormones
- HU Ahmed
- HW Daniell
- HW Gottfried
- HY Huang
- HY Tiong
- I Cervenakov
- I M Thompson
- I Tannock
- ID Kaplan
- IF Tannock
- IF Tannock
- IJ de Jong
- IJ de Jong
- IJ Powell
- IM Thompson
- IM Thompson
- IM Thompson
- IM Thompson
- IM Thompson
- IM Thompson
- IM Thompson
- IM Thompson
- IM Thompson
- IM Thompson Jr
- IT Koksal
- IW Cruijsen-Koeter van der
- J Ahn
- J Baillargeon
- J C Bailar
- J C Presti Jr
- J Clark
- J Clements
- J Crook
- J Cui
- J Dillner
- J Edwards
- J Edwards
- J Endrizzi
- J Engel
- J F Caubet
- J Fang
- J Groskopf
- J Huang
- J Hugosson
- J Hugosson
- J Irani
- J Kamradt
- J Kerr
- J Köllermann
- J Lapointe
- J Mezynski
- J Morote
- J Morote
- J Noldus
- J Noldus
- J Pannek
- J Philip
- J Picus
- J Rassweiler
- J Seidenfeld
- J Virtamo
- J W Moul
- J Walz
- J Xu
- J Xu
- J Xu
- J Xu
- J Xu
- J Xu
- J Zhu
- JA Connolly
- JA Smith Jr
- JB Nelson
- JB Nelson
- JC Hu
- JC Miller
- JC Ng
- JC Routh
- JD Brooks
- JD Cox
- JE Johansson
- JE Johansson
- JE McNeal
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- JE Nelson
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- JE Oesterling
- JE Oesterling
- JE Pontes
- JE Rosenberg
- JF Dorgan
- JF Ward
- JH Cohen
- JH Pinthus
- JI Epstein
- JI Epstein
- JI Epstein
- JI Epstein
- JI Epstein
- JI Epstein
- JI Epstein
- JI Epstein
- JI Epstein
- JI Epstein
- JI Izawa
- JI Izawa
- JJ Cartledge
- JJ Tosoian
- JK Fan
- JL Chin
- JL Stanford
- JM Chan
- JM Chan
- JM Chan
- JM Chan
- JM Chan
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- JM Crook
- JM Cunningham
- JM Farnham
- JM Jamison
- JM Mosquera
- JM Mosquera
- JM Richman
- JM Silverman
- JN Kabalin
- JP Long
- JR Smith
- JS de Bono
- JU Stolzenburg
- JU Stolzenburg
- JV Lacey Jr
- JW Denham
- JW Moul
- JW Moul
- JY Liang
- JY Ro
- K Akakura
- K Eichler
- K Fischer
- K Fizazi
- K Fizazi
- K Iguchi
- K Ito
- K Jung
- K Miller
- K Mistry
- K Mistry
- K Oishi
- K Pantel
- K Park
- K Rostad
- K Touijer
- K Yoshizawa
- KA Cooney
- KA Iczkowski
- KJ Gancarczyk
- KJ Helzlsouer
- KJ Pienta
- KK Hodge
- KK Hodge
- KM Sanderson
- KP Porkka
- KR Han
- KS Fizazi
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- KV Donkena
- KY Wolin
- L Benecchi
- L Boccon-Gibod
- L Boccon-Gibod
- L Cheng
- L Cheng
- L Collette
- L Curiel
- L Denis
- L Denis
- L Denis
- L H Klotz
- L Hergan
- L J Melton
- L Klotz
- L Klotz
- L Klotz
- L Klotz
- L Klotz
- L Kushi
- L Le Marchand
- L Maattanen
- L Rinnab
- L Rinnab
- L Salomon
- L Salomon
- L Turkeri
- L Twelker
- L Twelker
- L W Riba
- LA Kaplan
- la Taille A de
- La Taille A De
- LAG Ries
- LC Clark
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- LM Franks
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- LQ Qin
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- LS Marks
- M Bazinet
- M Beheshti
- M Blanc
- M Bolla
- M Bolla
- M Braga-Basaria
- M Caloglu
- M Cimitan
- M Colombel
- M Eichholzer
- M Farsad
- M Froehner
- M Froehner
- M Froehner
- M Froehner
- M Froehner
- M Froehner
- M G Oefelein
- M G Oefelein
- M G Oefelein
- M Garzotto
- M Gittelman
- M Gleave
- M Gleave
- M Graefen
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- M Graefen
- M Graefen
- M Han
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- M Holzman
- M Hussain
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- M Koch
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- M Ohori
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- N A Cruz Guerra
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- O Dillioglugil
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- P A Abrahamsson
- P Berthon
- P Castellucci
- P Castellucci
- P Cheetham
- P F Schellhammer
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- P Link
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- P M
- P Mukherjee
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- R A Stephenson
- R Berry
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- R Clements
- R Doll
- R Etzioni
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- R Heer
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- S Abuzallouf
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- S Kojima
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- S Liu
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- S Loeb
- S Loeb
- S Loeb
- S Loeb
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- S Nagrath
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- S Nilsson
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- S Thuroff
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- T A
- T Björk
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- T Hara
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- T Kato
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- T Loch
- T Loch
- T Loch
- T Loch
- T Otto
- T Pischon
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- T Schlomm
- T Schlomm
- T Schlomm
- T Schlomm
- T Schlomm
- T Schlomm
- T Sella
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- T Wiegel
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- TA Stamey
- TE Ahlering
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- U Zwergel
- UH Stenman
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- V Ficarra
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- WW Roberts
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- Y Jo
- Y Kojima
- Y S Zhu
- Y Wang
- YH Ko
- YP Yu
- Z Fuks
- Z Korodi
- Z Panteleakou
- ZA Alicikus
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study