Network Influence Based Classification and Comparison of Neurological Conditions

Variations in the influence of brain regions are used to classify neurological conditions by identifying eigenvector-based communities in connectivity matrices, generated from resting state functional magnetic resonance imaging scans. These communities capture the network influence of each brain region, revealing that the subjects with Alzheimer’s disease (AD) have a significantly lower degree of variation in their most influential brain regions when compared with healthy control (HC) and amnestic mild cognitive impairment (aMCI) subjects. Classification of subjects based on their pattern of influential regions is demonstrated with neural networks identifying HC, aMCI and AD subjects. The difference between these conditions are investigated by altering brain region influence so that a neural network changes a subject’s classification. This conversion is performed on healthy subjects changing to aMCI or AD, and for aMCI subjects changing to AD. The results highlight potential compensatory mechanisms that increase functional activity in certain regions for those with aMCI, such as in the right parahippocampal gyrus and regions in the default mode network, but these same regions experience significant decline in those that convert from aMCI to AD

Hierarchical Graphical Model for Learning Functional Network Determinants

Analysis of brain functionality is a stimulating research topic from both a neuroscientific and statistical perspective. Although several works have improved our comprehension of the relationship between subject-specific information and brain architecture, many questions remain open. The aim of this paper is to relate functional connectivity patterns with subject-specific features and brain constraints, such as age and mental illness of the subject and lobes membership for brain regions, and illustrate whether these phenotypes affect the neurophysiological dynamics. To address such goal we consider a modular approach that allows to remove noise from the fMRI data, estimate the functional dependency structure and relate functional architecture with structural and phenotypical information

Hierarchical Graphical Model for Learning Functional Network Determinants

Analysis of brain functionality is a stimulating research topic from both a neuroscientific and statistical perspective. Although several works have improved our comprehension of the relationship between subject-specific information and brain architecture, many questions remain open. The aim of this paper is to relate functional connectivity patterns with subject-specific features and brain constraints, such as age and mental illness of the subject and lobes membership for brain regions, and illustrate whether these phenotypes affect the neurophysiological dynamics. To address such goal we consider a modular approach that allows to remove noise from the fMRI data, estimate the functional dependency structure and relate functional architecture with structural and phenotypical information