Cumulative Effects of Neonatal Hyperoxia on Murine Alveolar Structure and Function

Background Bronchopulmonary dysplasia (BPD) results from alveolar simplification and abnormal development of alveolar and capillary structure. Survivors of BPD display persistent deficits in airflow and membrane and vascular components of alveolar gas diffusion. Despite being the defining feature of BPD, various neonatal hyperoxia models of BPD have not routinely assessed pulmonary gas diffusion. Methods To simulate the most commonly-utilized neonatal hyperoxia models, we exposed neonatal mice to room air or ≥90% hyperoxia during key stages of distal lung development: through the first 4 (saccular), 7 (early alveolar), or 14 (bulk alveolar) postnatal days, followed by a period of recovery in room air until 8 weeks of age when alveolar septation is essentially complete. We systematically assessed and correlated the effects of neonatal hyperoxia on the degree of alveolar–capillary structural and functional impairment. We hypothesized that the degree of alveolar–capillary simplification would correlate strongly with worsening diffusion impairment. Results Neonatal hyperoxia exposure, of any duration, resulted in alveolar simplification and impaired pulmonary gas diffusion. Mean Linear Intercept increased in proportion to the length of hyperoxia exposure while alveolar and total lung volume increased markedly only with prolonged exposure. Surprisingly, despite having a similar effect on alveolar surface area, only prolonged hyperoxia for 14 days resulted in reduced pulmonary microvascular volume. Estimates of alveolar and capillary structure, in general, correlated poorly with assessment of gas diffusion. Conclusion Our results help define the physiological and structural consequences of commonly-employed neonatal hyperoxia models of BPD and informtheir clinical utility

Intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery. ICP is observed in 0.4–1% of pregnancies in most areas of Central and Western Europe and North America, while in Chile and Bolivia as well as Scandinavia and the Baltic states roughly 5–15% and 1–2%, respectively, of pregnancies are associated with ICP. Genetic and hormonal factors, but also environmental factors may contribute to the pathogenesis of ICP. Intrahepatic cholestasis of pregnancy increases the risk of preterm delivery (19–60%), meconium staining of amniotic fluid (27%), fetal bradycardia (14%), fetal distress (22–41%), and fetal loss (0.4–4.1%), particularly when associated with fasting serum bile acid levels > 40 μmol/L. The hydrophilic bile acid ursodeoxycholic acid (10–20 mg/kg/d) is today regarded as the first line treatment for intrahepatic cholestasis of pregnancy. Delivery has been recommended in the 38th week when lung maturity has been established

Calibrated models of deicing agent solids, pavement texture, and specific conductivity of highway runoff

Field data and existing theory suggest that pavement texture governs the seasonal persistence of deicing agent solids and the storm scale variability of the specific conductivity of highway runoff. We measured precipitation, runoff, and specific conductivity for 50 storms over four deicing seasons at a highway drainage system in southeastern Massachusetts. An average pavement texture of 2.44mm was measured and 5.17×105kg of calcium magnesium acetate, salt, and premix applications was reported as well. Catchments and a depression storage layer model the highway drainage system, which routes hyetographs and slowly dissolving deicing agent solids to storm scale hydrographs and specific conductivity pollutographs. We equate the average pavement texture to the depression storage layer depth, which receives applied deicing agent solids, controls their dissolution during a storm, and governs their seasonal scale persistence. The observed average pavement texture, precipitation, and deicing agent applications yield first flush (storm scale) specific conductivity values in the depression storage layer that range from a winter maximum of 15mS/cm to summer values two orders of magnitude lower. The winter maximum, or seasonal scale first flush of specific conductivity, would be lower for rougher pavement due to slower dissolution. The rougher pavement would also induce stronger persistence of deicing agent solids throughout the year, so that appreciable storm scale first flushes would occur in the summer.1562-157

Response matrix minimization used in groundwater management with mathematical programming: A case study in a transboundary aquifer in Northern Greece

Groundwater has always been considered to be a readily available source of water for domestic, agricultural and industrial use. The last decades, the lack of policymaking for the utilization of groundwater, has led to overexploitation in many areas. The cooperation of a wide range of scientists such as mathematicians, engineers, computer scientists, environmentalists and economists - operation researchers, have led to the design and construction of commercial computer programs concerned on water management and specifically on the optimal distribution of limited water resources using groundwater management models. These combined models, via simulation and optimization algorithms, result in one optimal solution through operations research and mathematical programming methods. The groundwater management models are based on the method of space superposition or the combination of space and time superposition for steady and unsteady state problems, respectively. In the present study, an algorithm is presented, which minimizes the dimension of the response matrix, concerning on two assumptions: the first is the added fixed cost which represents the water supply pumping well and the second is the removal of time superposition. The study area is a transboundary phreatic aquifer in Northern Greece, in the area of Eidomeni, a small Hellenic village just on the borderline with FYROM. The aquifer has a total area of 10,84 km(2), 26 operating - pumping wells, which the 9 of them consist control points of the hydraulic head. The number of the management periods is 12 months