Haydar USUL Kayhan KUZEYL‹ Ertu¤rul ÇAKIR Dumbbell Shaped Giant Cell Tumor of the Temporal Bone: Case Report and Literature Review Temporal Kemi¤in Kumsaati Görünümlü Dev Hücreli Tümörü: Olgu Sunumu ve Literatürün Gözden Geçirilmesi

ABSTRACT We present a 29-year-old woman with a giant cell tumor of the temporal bone. The differential diagnosis is discussed with reference to the literature regarding giant cell lesions, especially of the cranium. KEY WORDS: Giant cell tumor, magnetic resonance imaging, temporal bone ÖZ 29 yaşındaki bir kadın hastada temporal kemiğin dev hücreli tümörü sunulmuştur. Hastalığın ayırıcı tanısı literatür ışığında özellikle kraniumu ilgilendiren dev hücreli lezyonlar açısından tartışılmıştır

Differences Between Essential Tremor Developing Parkinson's Disease and Essential Tremor

ÖZET Amaç: Esansiel tremor (ET) en yayg›n ekstrapiramidal hastal›kt›r ve baz› ET hastalar› sonradan Parkinson Hastal›¤› (PH) gelifltirebilirler. Ancak bugüne kadar kesin bir birliktelik tan›mlanmam›flt›r. Biz ET ve PH aras›ndaki iliflkiyi anlamak için, ET ile ET sonras› PH gelifltiren hastalar aras›ndaki farkl›l›klar› demografik ve klinik aç›dan araflt›rd›k. Yöntemler: Yüz k›rk dört ET ve 336 PH hastas› retrospektif olarak klinik kay›tla-r›ndan de¤erlendirildi ve yafl, cinsiyet, ET bafllama yafl›, ailede ET öyküsü, asimetrik veya simetrik tremor REM-uyku davran›fl bozuklu¤u (REM-SBD) öyküsü kaydedildi. Bulgular: Otuz üç PH öncesi ET'si olan hasta önceki klinik kay›tlar›na dayanarak ETPD hastas› olarak de¤erlendirildi. ET'den PH'e dönme süresi ortalama 12±11.4 y›l idi (1-47). Gruplar aras›nda cinsiyet farkl›l›¤› yoktu. ET hastalar›nda ETPD hastalar› ile karfl›laflt›r›ld›¤›nda ortalama yafl, ET bafllama yafl›, asimetrik tremor ve REM-SBD öyküsü anlaml› olarak daha azd›. ET hastalar›nda ailede ET öyküsü ve bafl tremoru ETPD'den daha fazla idi. Sonuç: Bizim sonuçlar›m›z asimetrik tremor, geç bafllang›çl› ET ve REM-SBD öyküsü olan ET hastalar›n›n sonradan PH gelifltirebilece¤ine dikkati çekmifltir. ABSTRACT Objective: Essential tremor (ET) is the most prevalent extrapyramidal disorder and some ET patients may later develop Parkinson's disease (PD). However, up to date, precise association was not determined. To understand the relationship between ET and PD, we investigated differences between patients with ET and ET developing PD (ETPD) in terms of demographic and clinical characteristics. Methods: One hundred forty-four patients with ET and 336 PD patients were retrospectively assessed from their clinical charts, and their current age, gender, onset age of ET, family history of ET, asymmetrical or symmetrical tremor and history of REM-Sleep Behavior Disorders (REM-SBD) were recorded. Results: Thirty-three patients who had ET prior to PD were evaluated as ETPD patients based on previous clinical records. The mean duration from ET to PD was 12±11.4 years (range: 1-47). There was no difference in gender between the groups. The mean age, the mean age at ET onset, asymmetrical tremor and REM-SBD history were significantly lower in ET patients compared to ETPD patients. The family history of ET and head tremor was more frequent in ET patients than in ETPD. Conclusions: Our results point out that some patients with ET, having asymmetrical tremor, late onset and REM-SBD history may develop PD

Persistent Hiccups with Fluvoxamine: a Case Report

ÖZET Fluvoksamin ile ‹liflkili Dirençli bir H›çk›r›k Vak'as› Majör depresyon tedavisi için fluvoksamin bafllanan 59 yafl›nda bir erkek hastada tedavinin 3. gü-nünde h›çk›r›k bafllad›. H›çk›r›k hemen bütün gün sürüyordu ve hastay› çok yormaktayd›. H›çk›r›k ancak fluvoksamin kesilince durdu. Yayg›n olmamakla birlikte, ilâçlar h›çk›r›¤a yol açabilmektedir. Bilgilerimize göre bu hasta literatürde bildirilen ilk fluvoksamin'le iliflkili dirençli h›çk›r›k vak'as›d›r. Fluvoksamin'in arac› oldu¤u muhtemel vagal bir mekanizma h›çk›r›k patogenezinde rol oynam›fl olabilir. ‹lâc›n neden oldu¤u h›çk›r›¤›n kesin teflhisi ancak vücuttan at›lmas› sonras›nda tablonun gerilemesinin gözlenmesi yoluyla konulabilir. Fluvoksamin ve muhtemelen di¤er SSG‹ grubu antidepresanlar dirençli h›çk›r›k olgular›n›n etiyopatogenezinde akla gelmesi gereken ajanlardand›r. Anahtar Kelimeler: h›çk›r›k, fluvoksamin, 5-HT reseptörleri, SSG‹ ABSTRACT Persistent Hiccups with Fluvoxamine: A Case Report. A 59-year-old man developed persistent hiccups 3 days after initiation of fluvoxamine treatment for major depressive disorder [MDD]. Hiccups were persistent and exhausting. Discontinuation of fluvoxamine finally resolved hiccups. Pharmacotherapeutic agents have been uncommonly associated with hiccups. To our knowledge, this is the first time in literature that persistent hiccups have been described in association with fluvoxamine treatment. A possible vagal mechanism mediated by fluvoxamine is hypothesized for the pathogenesis of hiccups in our patient. Diagnosis of drug-induced hiccups is generally achieved only by a process of elimination. Fluvoxamine and possibly other SSRI drugs should be considered to be ethiopathogenic in development of persistent hiccups