De novo 7p partial trisomy characterized by subtelomeric FISH and whole-genome array in a girl with mental retardation

Chromosome rearrangements involving telomeres have been established as one of the major causes of idiopathic mental retardation/developmental delay. This case of 7p partial trisomy syndrome in a 3-year-old female child presenting with developmental delay emphasizes the clinical relevance of cytogenetic diagnosis in the better management of genetic disorders. Application of subtelomeric FISH technique revealed the presence of interstitial telomeres and led to the ascertainment of partial trisomy for the distal 7p segment localized on the telomeric end of the short arm of chromosome 19. Whole-genome cytogenetic microarray-based analysis showed a mosaic 3.5 Mb gain at Xq21.1 besides the approximately 24.5 Mb gain corresponding to 7p15.3- > pter. The possible mechanisms of origin of the chromosomal rearrangement and the clinical relevance of trisomy for the genes lying in the critical regions are discussed

A divergent population of <i>Hemidactylus frenatus</i> Duméril & Bibron, 1836 (Reptilia: Gekkonidae) from the northern Eastern Ghats, India

A population of Hemidactylus cf. frenatus Duméril & Bibron, 1836, was recorded from Tyda and its vicinity in the Ananthagiri Hills, northern Eastern Ghats, Vishakhapatnam District, Andhra Pradesh, India. Evaluation of morphometric and meristic characters supported by karyotyping revealed that populations from the Ananthagiri Hills are considerably different from other populations of H. frenatus occurring in India. We provide the detailed description of the male of this divergent population