Historia rozwoju dermatologii i wenerologii na Podkarpaciu

Historia dermatologii i wenerologii na Podkarpaciu sięga XIX wieku. Dzięki wielkiemu poświęceniu i zaangażowaniu personelu medycznego możliwe było utworzenie pierwszych ośrodków dermatologicznych i wenerologicznych, niosących pomoc chorym ze schorzeniami skórnymi i chorobami przenoszonymi drogą płciową. Ciągłe starania i ciężka praca zaowocowały poprawieniem jakości i zwiększeniem dostępu pacjentów do świadczeń zdrowotnych. Obecnie na Podkarpaciu funkcjonuje sześć oddziałów dermatologicznych, a ponadto są tu liczne poradnie dermatologiczne, wyposażone w sprzęt pozwalający na diagnostykę oraz leczenie schorzeń dermatologicznych i poprawę komfortu życia chorych. W niniejszym artykule przedstawiono historię i rozwój wybranych oddziałów i poradni dermatologicznych na terenie Podkarpacia

Hornswogglers, whangdoodles and other dirty beasts : the comic grotesque in Roald Dahl's writings for children

The purpose of this thesis will be to substantiate the claim that Roald Dahl, the author of humorous writings for children, is simultaneously an avid creator of grotesque fiction. My argument is based on the premise that unless one views Dahl's texts in terms of their grotesque influence, critical evaluation of his work inevitably becomes reduced to a question of taste. A diachronic overview of the term "grotesque" is presented beginning with its delineation of an artistic mode in early Rome to its Rabelaisian extensions during the sixteenth century. The origins of the word are established, and its changing meaning throughout history is examined. A synchronic approach to the study follows, tracing both modern and post-modern theories of the grotesque. Of particular importance to the survey is Bakhtin's Rabelais and His World. By emphasizing the "positive, regenerating, creative" powers of laughter, Rabelais comes closest to defining the comic grotesque as embodied in Dahl's fiction. The final portion of the thesis is devoted to an interpretation of such texts as The Twits, George's Marvelous Medicine, and Charlie and the Chocolate Factory. Dahl's treatment of character, his development of plot, and his use of language are discussed in relation to previous theories of the grotesque. A psychological defense of the genre is offered as a conclusion to the study. Ultimately, the grotesque will be viewed in its cathartic role: helping children work through feelings of oppression in a world governed by adult authority

Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer?

Obesity is a complex and multifactorial problem of global importance. Additionally, obesity causes chronic inflammation, upregulates cell growth, disturbs the immune system, and causes genomic instability, increasing the risk of carcinogenesis. Colorectal cancer is one of the most common cancers, and it has become a global problem. In 2018, there were around 1.8 million new cases and around 881,000 deaths worldwide. Another risk factor of colorectal cancer associated with obesity is poor diet. A Western diet, including a high intake of red and processed meat and a low consumption of whole grains, fruits, vegetables, and fiber, may increase the risk of both colorectal cancer and obesity. Moreover, the Western diet is associated with a proinflammatory profile diet, which may also affect chronic low-grade inflammation. In fact, people with obesity often present gut dysbiosis, increased inflammation, and risk of colorectal cancer. In this article, the association between obesity and colorectal cancer is discussed, including the most important mechanisms, such as low-grade chronic inflammation, gut dysbiosis, and poor diet

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

Despite the increasing knowledge with regard to IBD (inflammatory bowel disease), including ulcerative colitis (UC) and Crohn’s disease (CD), the etiology of these conditions is still not fully understood. Apart from immunological, environmental and nutritional factors, which have already been well documented, it is worthwhile to look at the possible impact of genetic factors, as well as the composition of the microbiota in patients suffering from IBD. New technologies in biochemistry allow to obtain information that can add to the current state of knowledge in IBD etiology