Zachowania żywieniowe chorych na nowotwory hematologiczne — prospektywne badanie jednoośrodkowe

Introduction. Oncohaematological diseases are a special group of cancer diseases. An important role in their pathogenesis may play exposure to carcinogenic compounds, including substances present in food, such as polycyclic aromatic hydrocarbons (PAH), heterocyclic aromatic amines (HCA), acrylamide, nitrosamines or ethanol. Aims and assumptions were analysis of eating behaviours leading to the consumption of carcinogenic compounds and assessment of frequency of carcinogenic compounds intake. Material and methods. 201 patients with haematological cancers participated in the study. The survey used authorial questionnaire. Selected eating habits and frequency of carcinogenic compounds intake were examined in the study. The results were developed in the Statistica 12 program. Results. Patients presented different eating habits. 28.3% (N = 34) of the respondents did not read the compositions of the products they buy, regardless of their place of residence. 46.0% (N = 92) of respondents most often consumed fried products. Only 30% of men and women (N = 27) negated frying on the same fat. Most women — 44.3% (N = 39) declared consumption of pork, most men 44.2% (N = 50) of poultry. 58.2% of respondents (N = 117) were characterized by low frequency of PAH, HCA and nitrosamine intake. Only 0.5% (N = 1) of the patients had very low acrylamide intake; 56.2% (N = 113) average. 66.2% (N = 133) of the respondents had low frequency of alcohol consumption. Conclusions. Eating habits leading to the consumption of carcinogens are: not reading labels, frying and pork consumption. Patients with hematological cancers had average frequency of carcinogen intake and low frequency of alcohol consumption.Wstęp. Choroby onkohematologiczne są szczególną grupą chorób nowotworowych. Istotną rolę w ich patogenezie może odgrywać narażenie chorych na związki kancerogenne, w tym na substancje obecne w żywności. Należą do nich między innymi wielopierścieniowe węglowodory aromatyczne (PAH), heterocykliczne aminy aromatyczne (HCA), akrylamid, nitrozoaminy czy etanol. Celem i założeniem badania były analiza zachowań żywieniowych prowadzących do spożycia związków kancerogennych oraz ocena częstotliwości spożycia tych związków. Materiał i metody. W badaniu uczestniczyło 201 chorych na nowotwory hematologiczne. W sondażu wykorzystano autorski kwestionariusz ankiety. W pracy zbadano wybrane nawyki żywieniowe i częstotliwości spożycia związków kancerogennych. Wyniki opracowano w programie Statistica 12. Wyniki. Pacjenci prezentowali różne nawyki żywieniowe. Spośród badanych 28,3% (n = 34) nie czytało składów produktów, które kupuje, bez względu na miejsce zamieszkania. Spośród respondentów 46,0% (n = 92) najczęściej spożywało produkty smażone. Tylko 30,0% badanych mężczyzn i kobiet (n = 27) zanegowało smażenie potraw wielokrotnie na tym samym tłuszczu. Kobiety najczęściej — 44,3% (n = 39) — deklarowały spożycie mięsa wieprzowego, a mężczyźni — 44,2% (n = 50) — drobiowego. Spośród ankietowanych 58,2% (n = 117) charakteryzowało się niską częstotliwością spożycia PAH, HCA i nitrozoamin. Tylko 0,5% (n = 1) ankietowanych pacjentów miało bardzo niską częstotliwość spożycia akrylamidu; 56,2% (n = 113) charakteryzowało się jego średnią częstotliwością spożycia. 66,2% (n = 133) badanych cechowało się niską częstotliwością spożycia alkoholu. Wnioski. Nawyki żywieniowe prowadzące do spożycia kancerogenów to: brak czytania etykiet, smażenie, spożywanie wieprzowiny. Chorzy na nowotwory hematologiczne cechują się średnią częstotliwością spożycia kancerogenów i niską częstotliwością spożycia alkoholu

Synthetic genistein derivatives as modulators of glycosaminoglycan synthesis

Background: Mucopolysaccharidoses (MPS) are severe metabolic disorders caused by 26 accumulation of undegraded glycosaminoglycans (GAGs) in lysosomes due to defects in certain 27 lysosomal hydrolases. Substrate reduction therapy (SRT) has been proposed as one of potential 28 treatment procedures of MPS. Importantly, small molecules used in such a therapy might 29 potentially cross the blood-brain barrier (BBB) and improve neurological status of patients, as 30 reported for a natural isoflavone, 5, 7-dihydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, 31 also known as genistein. Although genistein is able to cross BBB to some extent, its delivery to 32 the central nervous system is still relatively poor (below 10% efficiency). Thus, we aimed to 33 develop a set of synthetically modified genistein molecules and characterize physicochemical as 34 well as biological properties of these compounds. Methods: Following parameters were 35 determined for the tested synthetic derivatives of genistein: cytotoxicity, effects on cell 36 proliferation, kinetics of GAG synthesis, effects on epidermal growth factor (EGF) receptor’s 37 tyrosine kinase activity, effects on lysosomal storage, potential ability to cross BBB. Results: We 38 observed that some synthetic derivatives inhibited GAG synthesis similarly to, or more 39 efficiently than, genistein and were able to reduce lysosomal storage in MPS III fibroblasts. The 40 tested compounds were generally of low cytotoxicity and had minor effects on cell proliferation. 41 Moreover, synthetic derivatives of genistein revealed higher lipophilicity (assessed in silico) than 42 the natural isoflavone. Conclusion: Some compounds tested in this study might be promising 43 candidates for further studies on therapeutic agents in MPS types with neurological symptoms

5-NITRO-2-PYRIDYL-1-THIOGLUCOSIDES: APPLICATION IN SYNTHESIS OF ANALOGUES OF GLYCOSYLTRANSFERASES NATURAL SUBSTRATES

Abstract: 5-Nitro-2-pyridyl-1-thioglucosides were used in synthesis of complex uridine derivatives (13-16) in two different sequences of reactions. In one route, the first step was glycosylation of selectively protected 5-nitro-2-pyridyl-1-thioglucoside 1 with two different glycosyl donors (5 or 6), next, the nitro group in aglycone of obtained disaccharides 7 or 8 was reduced and then obtained products 9 or 10 were condensed with uridine derivatives 3 or 4 using DMT-MM as condensing agent under microwave irradiation. In the second route, condensation and glycosylation reactions were applied in reverse order. As it turned up, a sequence of reactions affected the yield of final glycoconjugates 13-16 and depended on the type of uridine derivatives used

Alternative binder for copper concentrate briquetting

In the paper, results of investigations on the use of new, alternative binder, based on technical grade glycerine and higher alcohols, for copper matte briquetting are presented. The use of alternative binder yields briquettes that show better drop and compressive strength properties compared with briquettes produced using traditional, sulphite lye binding material

A gloss on Stanisława Hornowska

Stanisława Hornowska is the addressee of Cyprian Norwid's poem with the first line A pani cóż ja powiem? (And what will I say to you, madam?) that could have been written in the summer of 1857 in Paris. There is no information about Hornowska in the next editions of the poet's works, starting with Pisma zebrane (Collected Works) edited by Zenon Przesmycki. Also Kalendarz życia i twórczości Cypriana Norwida (A Calendar of Cyprian Norwid' Life and Work) of 2007 describes her fate, as well as the fate of her relations from Łochów, as not known. However, examination of manuscript sources and other dispersed biographical notes has allowed the author to verify guesses about who Stanisława Hornowska was; it also has allowed determining the date and place of her death, although the year she was born is still unknown. Unpublished as yet notes by Łucja Hornowska nee Dunin-Borkowska (Stanisława's brother's wife) kept in the collection of the National Library have played the key role here. The article also organizes the information about the other members of the Hornowski family of Łochów, contemporary with Norwid, with whom the poet was in contact