Mosquitoes LTR Retrotransposons: A Deeper View into the Genomic Sequence of Culex quinquefasciatus

A set of 67 novel LTR-retrotransposon has been identified by in silico analyses of the Culex quinquefasciatus genome using the LTR_STRUC program. The phylogenetic analysis shows that 29 novel and putatively functional LTR-retrotransposons detected belong to the Ty3/gypsy group. Our results demonstrate that, by considering only families containing potentially autonomous LTR-retrotransposons, they account for about 1% of the genome of C. quinquefasciatus. In previous studies it has been estimated that 29% of the genome of C. quinquefasciatus is occupied by mobile genetic elements

Endovideosurgical aspects of treatment of bilateral inguinal hernias

OBJECTIVE. The article detected risk factors of supravesial hernia formation and its recurrence in patients with bilateral inguinal hernias after laparoscopic herniaplasty. The authors would like to develop strategy in order to solve this problem. MATERIAL AND METHODS. An analysis of treatment results was made in 84 patients. The research was based on ultrasound clinical data at the period of 3-5 years after operation. RESULTS. Factors of high recurrence rate and supravesial herhia formation were identified as combination of features of work activity and increased physical exertion accompanied by chronic diseases and regular intra-abdominal rise of pressure. The algorithm of choice among various laparoscopic methods of surgery was designed. Total prosthesis of supravesial and inguinal regions using developed original technique is recommended for application in cases of high risk group. Standard separate hernioplasty could be used in an absence of high risk. CONCLUSIONS. The proposed algorithm allowed doctors to reduce the rate of recurrence and formation of supravesial hernias

CLINICAL EXPERIENCE OF NEXAVAR (SORAFENIB) APPLICATION IN PATIENTS WITH METASTATIC DIFFERENTIATED THYROID CANCER RESISTANT TO THERAPY 131I

The treatment choice of differentiated thyroid cancer resistant to therapy 131I to be restricted just to systemic methods. Traditional chemotherapy demonstrated no clinically relevant effectiveness but high toxicity. With the introduction into clinical practice of multi-kinase inhibitor was able to significantly improve treatment outcomes.The paper demonstrated two patients with the incurable of differentiated thyroid cancer resistant to therapy 131I. All patients received Nexavar (sorafenib). Its therapeutic effectiveness varied from partial response to long-term stabilization

Prospective comparative study of intraoperative balloon electronic brachytherapy versus resection with multidisciplinary adjuvant therapy for recurrent glioblastoma

Background: Intraoperative balloon electronic brachytherapy (IBEB) may provide potential benefit for local control of recurrent cerebral glioblastomas (GBMs). Methods: This is a preliminary report of an open-label, prospective, comparative cohort study conducted in two neurosurgical centers with ongoing follow-up. At recurrence, patients at one center (n = 15) underwent re-resection with IBEB while, at the second center (n = 15), control subjects underwent re-resection with various accepted second-line adjuvant chemoradiotherapy options. A comparative analysis of overall survival (OS) and local progression-free survival (LPFS) following re-resection was performed. Exploratory subgroup analysis based on postoperative residual contrast-enhanced volume status was also done. Results: In the IBEB group, median LPFS after re-resection was significantly longer than in the control group (8.0 vs. 6.0 months; log rank x2 = 4.93, P = 0.026, P < 0.05). In addition, the median OS after second resection in the IBEB group was also significantly longer than in the control group (11.0 vs. 8.0 months; log rank x2 = 4.23, P = 0.04, P < 0.05). Conclusion: These hypothesis-generating results from a small cohort of subjects suggest putative clinical benefit in OS and LPFS associated with maximal safe re-resection of recurrent GBM with IBEB versus re-resection and standard adjuvant therapy, a hypothesis that deserves further testing in an appropriately powered clinical trial. © 2021 Scientific Scholar. All rights reserved

Neoadjuvant target therapy of differentiated thyroid cancer (clinical observation)

In the article a case of non-resectable differentiated thyroid cancer (DTC) is described. A recurrent thyroid tumor deforms the oropharyngeal lumen and laryngeal vestibule and bears down on the left esophageal wall and trachea. The authors present literature data on Nexavar target therapy and focus on the fact that no cases of combination treatment with target therapy and surgery of non-resectable progressive DTC were described until now. In view of this, this clinical report is unique and dictates a need to determine new Nexavar (Sorafenib) indications for use in a neoadjuvant regimen

Composition and Distribution of Plankton Communities in the Atlantic Sector of the Southern Ocean

In recent decades, the waters off the Antarctic Peninsula and surrounding region have undergone a significant transformation due to global climate change affecting the structure and distribution of pelagic fauna. Here, we present the results of our study on the taxonomic composition and quantitative distribution of plankton communities in Bransfield Strait, Antarctic Sound, the Powell Basin of the Weddell Sea, and the waters off the Antarctic Peninsula and South Orkney Islands during the austral summer of 2022. A slight warming of the Transitional Zonal Water with Weddell Sea influence (TWW) and an increase in its distribution area was detected. Among the pelagic communities, three groups were found to be the most abundant: copepods Calanoides acutus, Metridia gerlachei, and Oithona spp., salpa Salpa thompsoni, and Antarctic krill Euphausia superba. Euphausiids were found in cases of low abundance, species diversity, and biomass. In the studied region, an increase in the amount of the salpa S. thompsoni and the euphausiid Thysanoessa macrura and the expansion of their distribution area were observed. Significant structural shifts in phytoplankton communities manifested themselves in changes in the structure of the Antarctic krill forage base. The composition and distribution of pelagic fauna is affected by a combination of environmental abiotic factors, of which water temperature is the main one. The obtained results have allowed us to assume that a further increase in ocean temperature may lead to a reduction in the number and size of the Antarctic krill population and its successive replacement by salps and other euphausiids that are more resistant to temperature fluctuations and water desalination

Composition and Distribution of Plankton Communities in the Atlantic Sector of the Southern Ocean

In recent decades, the waters off the Antarctic Peninsula and surrounding region have undergone a significant transformation due to global climate change affecting the structure and distribution of pelagic fauna. Here, we present the results of our study on the taxonomic composition and quantitative distribution of plankton communities in Bransfield Strait, Antarctic Sound, the Powell Basin of the Weddell Sea, and the waters off the Antarctic Peninsula and South Orkney Islands during the austral summer of 2022. A slight warming of the Transitional Zonal Water with Weddell Sea influence (TWW) and an increase in its distribution area was detected. Among the pelagic communities, three groups were found to be the most abundant: copepods Calanoides acutus, Metridia gerlachei, and Oithona spp., salpa Salpa thompsoni, and Antarctic krill Euphausia superba. Euphausiids were found in cases of low abundance, species diversity, and biomass. In the studied region, an increase in the amount of the salpa S. thompsoni and the euphausiid Thysanoessa macrura and the expansion of their distribution area were observed. Significant structural shifts in phytoplankton communities manifested themselves in changes in the structure of the Antarctic krill forage base. The composition and distribution of pelagic fauna is affected by a combination of environmental abiotic factors, of which water temperature is the main one. The obtained results have allowed us to assume that a further increase in ocean temperature may lead to a reduction in the number and size of the Antarctic krill population and its successive replacement by salps and other euphausiids that are more resistant to temperature fluctuations and water desalination