John Fox Jr.\u27s Commentary on the Roles of Women in the Progressive Era.

John Fox, Jr. provides commentary on the changing roles of Progressive Era women in The Trail of the Lonesome Pine, The Little Shepherd of Kingdom Come, “A Cumberland Vendetta,” and “The Pardon of Becky Day.” Fox’s portrayals provide evidence that although he recognized the changes in his society with women spearheading reform, he did not entirely approve of these changes or of women taking an aggressive role in advocating change. This thesis provides textual examples and analysis demonstrating Fox’s beliefs. Chapter two focuses on the stories of “The Pardon of Becky Day” and “A Cumberland Vendetta.” Chapter three analyzes The Little Shepherd of Kingdom Come and focuses on the relationships of Chad Buford, Margaret Dean, and a mountain girl named Melissa. Chapter four analyzes the relationship between June Tolliver and Jack Hale from The Trail of the Lonesome Pine. Chapter five concludes the thesis and analysis of Fox’s commentary on women and gender roles

Recension : Les pédagogies de ré-imagination et de désapprentissage : Les dommages du décolonialisme au sein/contre les tenants du colonialisme au Canada

This book review is a close reading of three book-length works by key, contemporary scholars in the field of settler colonial studies: Walter Mignolo and Catherine Walsh's On Decoloniality; Adam Dahl's The Empire of the People; and Emma Battell Lowman and Adam Barker's Settler: Identity and Colonialism in 21st Century Canada. This review provides a critical account of the significance of navigating the complexities of modern settler colonial practices and frameworks within Western settler societies to better inform and navigate our own decolonizing processes. We identify settler logics, perspectives and foundational frameworks as key factors in our current educative practices. Through this, we debate the significance of unsettling our/selves to consider extensions of our identities through a decolonial lens and how we, as a society, contribute to ongoing colonial processes. The review also provides approaches to how these resources may be used to deepen our anti-colonial lens by considering these texts as an underlying basis to reflect upon current educative curricula.Ce travail est une analyse minutieuse sur les critiques des trois ouvrages écrits par des universitaires contemporains de référence dans le domaine des études décoloniales : La Décolonisation (On Decoloniality) de Walter Mignolo et Catherine Walsh; L’Empire du Peuple (The Empire of the People) de Adam Dahl; et Les Colons : Identité et colonialisme en 21ème siècle au Canada (Settler: Identity and Colonialism in 21st Century Canada) de Emma Battell Lowman et Adam Barker. Cette étude fournit un compte rendu critique de l’importance d’explorer les éléments complexes constituant les structures et les pratiques du système colonialisme moderne à l’intérieur des sociétés occidentales coloniales afin de mieux nous informer et nous diriger dans nos propres processus de décolonisation. Nous identifions les logiques, les perspectives et les cadres référentiels des colons qui sont des facteurs clés de nos pratiques éducatives actuelles. A travers cette analyse, nous discutons de l’importance de nous défaire nous-mêmes en considérant les héritages de nos identités sous un angle décolonial et comment nous, en tant que société, contribuons aux processus du système colonialisme actuel. L’analyse fournit aussi une approche sur la façon dont ces ressources peuvent être utilisées pour approfondir notre vision anticoloniale en considérant ces écrits comme un fondement sur lequel se reposent les curricula actuels

Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest. p16INK4a expression, a marker for aging and senescence in T-cells, is associated with lower intracellular concentrations of endogenous nucleotides (EN) and nucleos(t)ide reverse transcriptase inhibitors (NRTIs). This study expands on these findings by determining whether inflammation is contributing to the association of p16INK4a expression with intracellular metabolite (IM) exposure and endogenous nucleotide concentrations

Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design

Quantifying tissue drug concentrations can yield important information during drug development, but complicates pharmacokinetic study design. Mucosal fluids collected by direct aspiration(cervicovaginal fluid; CVF) or swab(rectal fluid; RF) might be used as tissue concentration surrogates, but these relationships are not well characterized

A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine

Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP)

Complex flow in the nasal region of guitarfishes

Scent detection in an aquatic environment is dependent on the movement of water. We set out to determine the mechanisms for moving water through the olfactory organ of guitarfishes (Rhinobatidae, Chondrichthyes) with open nasal cavities. We found at least two. In the first mechanism, which we identified by observing dye movement in the nasal region of a life-sized physical model of the head of Rhinobatos lentiginosus mounted in a flume, olfactory flow is generated by the guitarfish's motion relative to water, e.g. when it swims. We suggest that the pressure difference responsible for motion-driven olfactory flow is caused by the guitarfish's nasal flaps, which create a region of high pressure at the incurrent nostril, and a region of low pressure in and behind the nasal cavity. Vortical structures in the nasal region associated with motion-driven flow may encourage passage of water through the nasal cavity and its sensory channels, and may also reduce the cost of swimming. The arrangement of vortical structures is reminiscent of aircraft wing vortices. In the second mechanism, which we identified by observing dye movement in the nasal regions of living specimens of Glaucostegus typus, the guitarfish's respiratory pump draws flow through the olfactory organ in a rhythmic (0.5-2 Hz), but continuous, fashion. Consequently, the respiratory pump will maintain olfactory flow whether the guitarfish is swimming or at rest. Based on our results, we propose a model for olfactory flow in guitarfishes with open nasal cavities, and suggest other neoselachians which this model might apply to

Motion-driven flow in an unusual piscine nasal region

Fishes have several means of moving water to effect odorant transport to their olfactory epithelium (‘olfactory flow’). Here we show that olfactory flow in the adult garpike Belone belone (Belonidae, Teleostei), a fish with an unusual nasal region, can be generated by its motion relative to water (swimming, or an external current, or both). We also show how the unusual features of the garpike’s nasal region influence olfactory flow. These features comprise a triangular nasal cavity in which the olfactory epithelium is exposed to the external environment, a papilla situated within the nasal cavity, and an elongated ventral apex. To perform our investigation we first generated life-like plastic models of garpike heads from X-ray scans of preserved specimens. We then suspended these models in a flume and flowed water over them to simulate swimming. By directing filaments of dye at the static models, we were able to visualise flow in the nasal regions at physiologically relevant Reynolds numbers (700–2,000). We found that flow of water over the heads did cause circulation in the nasal cavity. Vortices may assist in this circulation. The pattern of olfactory flow was influenced by morphological variations and the asymmetry of the nasal region. The unusual features of the nasal region may improve odorant sampling in the garpike, by dispersing flow over the olfactory epithelium and by creating favourable conditions for odorant transport (e.g. steep velocity gradients). Unexpectedly, we found that the mouth and the base of the garpike’s jaws may assist the sampling process. Thus, despite its apparent simplicity, the garpike’s nasal region is likely to act as an effective trap for odorant molecules

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG

The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific ERG domains and co-factors contributing to leukemogenesis are poorly understood. Drug targeting a transcription factor such as ERG is challenging. Our study reveals the critical role of a conserved amino acid, proline, at position 199, located at the 3' end of the PNT (pointed) domain, in ERG's ability to induce leukemia. P199 is necessary for ERG to promote self-renewal, prevent myeloid differentiation in hematopoietic progenitor cells, and initiate leukemia in mouse models. Here we show that P199 facilitates ERG's interaction with the NCoR-HDAC3 co-repressor complex. Inhibiting HDAC3 reduces the growth of ERG-dependent leukemic and prostate cancer cells, indicating that the interaction between ERG and the NCoR-HDAC3 co-repressor complex is crucial for its oncogenic activity. Thus, targeting this interaction may offer a potential therapeutic intervention