Moden und Toiletten-Brevier : Unentbehrliches und Entbehrliches aus dem Gebiete von Tracht und Mode, Toilette und Putz, Zierrath und Schmuck /

includes index.History of womens' style and fashion including hairstyles and accessories. Illustrations include vignettes at chapter heads.Mode of access: Internet.Cream color cloth binding; spine and upper cover titled in gold.Inscription: Lydia LehaiferACQ: 35669; Janice B. Longone; Gift; 6/21/2001

"Innovation is at the heart of everything we do" - How to sustain innovation and entrepreneurship, the case of Spotify

Vad är innovation inom en organisation, och varför kämpar så många företag med att förnya sig? Syftet med denna uppsats var att undersöka på vilka sätt etablerade företag lyckas bibehålla sin innovation och entreprenörsanda, genom att se till två huvudaspekter vilka berör ett företags kultur och struktur. Målet var också att bidra till ämnet entreprenörskap, och undersökningsfrågan besvarades genom användandet av företaget Spotify som fallstudie. Studien var iterativ och genomfördes via kvalitativa intervjuer och insamlad sekundärdata som berörde fallstudieföretaget Spotify. De teoretiska perspektiven baserades på de två huvudaspekterna kring hur innovation kan bibehållas via kultur och struktur. Dessa delades upp i ytterligare underrubriker, som exempelvis hierarki och graden av kontroll, gruppsammansättning samt kommunikation. Den empiriska data som samlades in om fallstudieföretaget Spotify berörde på vilka vis de arbetar med innovation och entreprenörskap. Slutsatserna som kunde dras, baserad på den insamlade teoretiska och empiriska data, var att en entrepreneöriell organisation som uppmuntrar till innovation bland annat är decentraliserad, fokuserad på autonomi och flexibilitet, baserad på grupper, har avsatt tid för lärande och innation, har stödfunktioner, en öppen kommunikation samt stödjer felaktigheter och misstag.What is organizational innovation, and why do so many companies struggle with their revitalization? The purpose of this thesis was to examine in which ways established companies are able to sustain their innovativeness and entrepreneurial spirit, by looking at the main aspects of the company’s culture and structure. The aim was also to contribute to the field of entrepreneurship and the question was answered using Spotify as a case study. The study was iterative and conducted through a case study of the company Spotify, using qualitative interviews and secondary sources. The theoretical perspectives was based on two main notions of how to sustain innovation through structure and culture. These were divided into further headings, such as hierarchy and span of control, team composition and communication. The empirical data was collected on the case study company Spotify and in which ways they work with innovation and entrepreneurship . The conclusions drawn where, based on the theoretical and empirical data collected, that an entrepreneurial organization which promotes innovation is among others decentralized, focused on autonomy and flexibility, built on teams, with time set aside for learning and innovation, has support mechanisms, an open communication and supports failures and mistakes

Amplification of ERBB2 (HER2) in embryonal rhabdomyosarcoma : A potential treatment target in rare cases?

The ERBB2 gene encodes a receptor tyrosine kinase also known as HER2. The gene is amplified and overexpressed in one-fifth of breast carcinomas; patients with such tumors benefit from targeted treatment with trastuzumab or other drugs blocking the receptor. In addition, ERBB2 has been shown to be amplified and/or overexpressed in a variety of other malignancies. Notably, both alveolar and embryonal rhabdomyosarcoma (RMS), especially in children, often show increased expression of ERBB2. Although high-level amplification of the gene has not been described in RMS, its frequent expression at the cell surface of RMS cells has been exploited for chimeric antigen receptor T-cell (CAR T)-based treatment strategies. We here describe two cases of pediatric, fusion-negative embryonal RMS with high-level amplification of the ERBB2 gene. One patient is currently treated with conventional chemotherapy for a recently detected standard risk RMS, whereas the other patient died from metastatic disease. Both tumors displayed focal amplicons (210 and 274 Kb, respectively) in chromosome band 17q12, with proximal and distal borders corresponding to those typically seen in breast cancer. In both tumors, the ERBB2 amplicon correlated with high expression at the RNA and protein levels. Thus, breast cancer-like ERBB2 amplification is a very rare, but recurrent feature of pediatric RMS, and should be exploited as an alternative treatment target.Funding Agencies|Governmental Funding of Clinical Research within the National Health Service of Sweden; Swedish Cancer SocietySwedish Cancer Society; Swedish Childhood Cancer Fund</p

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

The synaptic connections that form between neurons during development remain plastic and able to adapt throughout the lifespan, enabling learning and memory. However, during aging and in particular in neurodegenerative diseases, synapses become dysfunctional and degenerate, contributing to dementia. In the case of Alzheimer’s disease (AD), synapse loss is the strongest pathological correlate of cognitive decline, indicating that synaptic degeneration plays a central role in dementia. Over the past decade, strong evidence has emerged that oligomeric forms of amyloid beta, the protein that accumulates in senile plaques in the AD brain, contribute to degeneration of synaptic structure and function. More recent data indicate that pathological forms of tau protein, which accumulate in neurofibrillary tangles in the AD brain, also cause synaptic dysfunction and loss. In this review, we will present the case that soluble forms of both amyloid beta and tau protein act at the synapse to cause neural network dysfunction, and further that these two pathological proteins may act in concert to cause synaptic pathology. These data may have wide-ranging implications for the targeting of soluble pathological proteins in neurodegenerative diseases to prevent or reverse cognitive decline