Theoretical models of planetary system formation. II. Post-formation evolution

We extend the results of planetary formation synthesis by computing the long-term evolution of synthetic systems from the clearing of the gas disk into the dynamical evolution phase. We use the symplectic integrator SyMBA to numerically integrate the orbits of planets for 100 Ma, using populations from previous studies as initial conditions.We show that within the populations studied, mass and semi-major axis distributions experience only minor changes from post-formation evolution. We also show that, depending upon their initial distribution, planetary eccentricities can statistically increase or decrease as a result of gravitational interactions. We find that planetary masses and orbital spacings provided by planet formation models do not result in eccentricity distributions comparable to observed exoplanet eccentricities, requiring other phenomena such as e.g. stellar fly-bys to account for observed eccentricities

Theoretical models of planetary system formation: mass vs semi-major axis

Planet formation models have been developed during the last years in order to try to reproduce the observations of both the solar system, and the extrasolar planets. Some of these models have partially succeeded, focussing however on massive planets, and for the sake of simplicity excluding planets belonging to planetary systems. However, more and more planets are now found in planetary systems. This tendency, which is a result of both radial velocity, transit and direct imaging surveys, seems to be even more pronounced for low mass planets. These new observations require the improvement of planet formation models, including new physics, and considering the formation of systems. In a recent series of papers, we have presented some improvements in the physics of our models, focussing in particular on the internal structure of forming planets, and on the computation of the excitation state of planetesimals, and their resulting accretion rate. In this paper, we focus on the concurrent effect of the formation of more than one planet in the same protoplanetary disc, and show the effect, in terms of global architecture and composition of this multiplicity. We use a N-body calculation including collision detection to compute the orbital evolution of a planetary system. Moreover, we describe the effect of competition for accretion of gas and solids, as well as the effect of gravitational interactions between planets. We show that the masses and semi-major axis of planets are modified by both the effect of competition and gravitational interactions. We also present the effect of the assumed number of forming planets in the same system (a free parameter of the model), as well as the effect of the inclination and eccentricity damping.Comment: accepted in Astronomy and Astrophysic

Macroscopic effects in attosecond pulse generation

We examine how the generation and propagation of high-order harmonics in a partly ionized gas medium affect their strength and synchronization. The temporal properties of the resulting attosecond pulses generated in long gas targets can be significantly influenced by macroscopic effects, in particular by the intensity in the medium and the degree of ionization. Under some conditions, the use of gas targets longer than the absorption length can lead to the generation of self-compressed attosecond pulses. We show this effect experimentally, using long argon-filled gas cells as generating medium.Comment: 5 pages 4 figure

Status of the ALICE magnet system

ALICE is the LHC experiment dedicated to heavy ion (Pb, Ca) physics. ALICE will be installed in point 2 of LHC, the former point 2 of LEP. The luminosity at the interaction point will be in the order of 10 /sup 27/ (10/sup 31/ for p-p). Consequently, the radiation level in ALICE will be comparatively low. We will use the existing infrastructure. Therefore, no noticeable civil engineering work will be necessary. Minor modifications will be made to gain a second access to the experiment cavern-mainly for the union arm spectrometer. ALICE will reuse the L3 solenoid, which is already installed and has been used in LEP as spectrometer magnet. A dipole magnet with a very large aperture is in addition required for the Dimuon Arm spectrometer and will be installed next to the L3 solenoid. The detectors in ALICE are concentrated around the IP inside L3 (Barrel) and along the muon arm. Some small forward detectors will be located toward the injection area at a larger distance from IP (~100 m). After a review of the present status of both projects some important milestones will be highlighted in the conclusion. (9 refs)

Cardiac magnetic resonance imaging for the detection of myocardial involvement in granulomatosis with polyangiitis

The prevalence of undiagnosed cardiac involvement in granulomatosis with polyangiitis (GPA) is unknown. In this prospective study we investigated the utility of cardiovascular magnetic resonance (CMR) to identify myocardial abnormalities in GPA and their correlation with disease phenotype. Twenty-six patients with GPA and no cardiovascular disease or diabetes mellitus underwent contrast-enhanced CMR, including late gadolinium-enhancement (LGE), T1-mapping for native T1 and extra-cellular volume (ECV) quantification for assessment of myocardial fibrosis, cine imaging and tissue tagging for assessment of left ventricular (LV) function. Twenty-five healthy volunteers (HV) with comparable age, sex, BMI and arterial blood pressure served as controls. Patients with GPA had similar cardiovascular risk profile to HV. A focal, non-ischaemic LGE pattern of fibrosis was detected in 24% of patients and no controls (p = 0.010). Patients with myocardial LGE were less frequently PR3 ANCA (7% vs 93%, p = 0.007), and had involvement of the lower respiratory tract and skin. LGE scar mass was higher in patients presenting with renal involvement. Native T1 and ECV were higher in patients with GPA than HV; ECV was higher in those with relapsing disease, and native T1 was inversely associated with PR3 ANCA (β = − 0.664, p = 0.001). Peak systolic strain was slightly reduced in GPA compared to controls; LV ejection function was inversely correlated with disease duration (β = − 0.454, p = 0.026). Patients with GPA have significant myocardial abnormalities on CMR. ANCA, systemic involvement and disease severity were associated with myocardial fibrosis. CMR could be a useful tool for risk stratification of myocardial involvement in GPA

Continuous infusion of physostigmine in patients with perioperative septic shock: A pharmacokinetic/pharmacodynamic study with population pharmacokinetic modeling

Background In the context of the cholinergic anti-inflammatory pathway, the clinical trial Anticholium® per Se (EudraCT Number: 2012-001650-26, ClinicalTrials.gov NCT03013322) addressed the possibility of taking adjunctive physostigmine salicylate treatment in septic shock from bench to bedside. Pharmacokinetics (PK) are likely altered in critically ill patients; data on physostigmine PK and target concentrations are sparse, particularly for continuous infusion. Our objective was to build a population PK (popPK) model for physostigmine, and further evaluate pharmacodynamics (PD) and concentration-response relationship in this setting. Methods In the randomized, double-blind, placebo-controlled trial, 20 patients with perioperative septic shock either received an initial dose of 0.04 mg/kg physostigmine salicylate, followed by continuous infusion of 1 mg/h for up to 120 h, or equivalent volumes of 0.9% sodium chloride (placebo group). Physostigmine plasma concentrations and acetylcholinesterase (AChE) activity were measured; concentration-response associations were evaluated, and popPK and PD modeling was performed with NONMEM. Results Steady state physostigmine plasma concentrations reached 7.60 ± 2.81 ng/mL (mean ± standard deviation [SD]). PK was best described by a two-compartment model with linear clearance. Significant covariate effects were detected for body weight and age on clearance, as well as a high inter-individual variability of the central volume of distribution. AChE activity was significantly reduced to 30.5%–50.6% of baseline activity during physostigmine salicylate infusion. A sigmoidal direct effect PD model best described enzyme inhibition by physostigmine, with an estimated half maximal effective concentration (EC50) of 5.99 ng/mL. Conclusions PK of physostigmine in patients with septic shock displayed substantial inter-individual variability with body weight and age influencing the clearance. Physostigmine inhibited AChE activity with a sigmoidal concentration-response effect

Attosecond electron spectroscopy using a novel interferometric pump-probe technique

We present an interferometric pump-probe technique for the characterization of attosecond electron wave packets (WPs) that uses a free WP as a reference to measure a bound WP. We demonstrate our method by exciting helium atoms using an attosecond pulse with a bandwidth centered near the ionization threshold, thus creating both a bound and a free WP simultaneously. After a variable delay, the bound WP is ionized by a few-cycle infrared laser precisely synchronized to the original attosecond pulse. By measuring the delay-dependent photoelectron spectrum we obtain an interferogram that contains both quantum beats as well as multi-path interference. Analysis of the interferogram allows us to determine the bound WP components with a spectral resolution much better than the inverse of the attosecond pulse duration.Comment: 5 pages, 4 figure

Design and Status of the Dipole Spectrometer Magnet for the ALICE Experiment

Proposal of abstract for MT16, Tallahesse, Florida, 26th September to 2nd October 1999.A large Dipole Magnet is required for the Muon Arm Spectrometer of the ALICE experiment at the LHC.The absence of strong requirements on the symmetry and homogeneity of the magnetic field has lead to a design dominated by economic and feasibility considerations.In March 1997 the decision was taken to build a resistive dipole magnet for the muon spectrometer of the ALICE experiment. Since then, design work has been pursued in JINR/Russia and at CERN. While a common concept has been adopted for the construction of the steel core, two different proposals have been made for the manufacturing technology of the excitation coils. In both cases, however, the conductor material will be Aluminium.The general concept of the dipole magnet is based on a window frame return yoke, fabricated from low carbon steel sheets. The flat vertical poles follow the defined acceptance angle of 9 degrees. The excitation coils are of saddle type. The coils are wound from large hollow Aluminium profiles. They are cooled by pressurized demineralised water. The coil ends are located to both sides of the magnet yoke and determine the overall length of the magnet. The main flux direction in the gap is horizontal and perpendicular to the LHC beam axis.Both coil concepts and the underlying manufacturing technology are compared and the present status of the development of the magnet is described