Fate-fakirs. Vocal score

Produced by the Hasty Pudding Club of Harvard, 1908

Tagore poems

For medium voice and piano. --- Text from Gitanjali by Rabindranath Tagore. --- English words also printed as text preceding each selection. --- On many an idle day-- -- If it is the pang of separation-- -- Beautiful is thy wristlet-- -- If it is not my portion-

Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar neurodegeneration

Here, we show that the murine neurodegenerative disease mdf (autosomal recessive mouse mutant ‘muscle deficient') is caused by a loss-of-function mutation in Scyl1, disrupting the expression of N-terminal kinase-like protein, an evolutionarily conserved putative component of the nucleocytoplasmic transport machinery. Scyl1 is prominently expressed in neurons, and enriched at central nervous system synapses and neuromuscular junctions. We show that the pathology of mdf comprises cerebellar atrophy, Purkinje cell loss and optic nerve atrophy, and therefore defines a new animal model for neurodegenerative diseases with cerebellar involvement in humans