Purchase orders and purchase records

The writer has recently collected information concerning the purchasing policies and methods of seven industrial corporations. Four of these companies would rank among the largest and best organized in this country and the others are representative concerns in their respective fields. It is well to look to the methods of the largest corporations for examples of efficient practice, for such companies have been more successful generally in developing the simplest and most effectual means of organization. Despite the fact that the requirements of large corporations are necessarily far more varied, their methods are usually applicable in principle to smaller concerns

Mapping Synaptic Pathology within Cerebral Cortical Circuits in Subjects with Schizophrenia

Converging lines of evidence indicate that schizophrenia is characterized by impairments of synaptic machinery within cerebral cortical circuits. Efforts to localize these alterations in brain tissue from subjects with schizophrenia have frequently been limited to the quantification of structures that are non-selectively identified (e.g., dendritic spines labeled in Golgi preparations, axon boutons labeled with synaptophysin), or to quantification of proteins using methods unable to resolve relevant cellular compartments. Multiple label fluorescence confocal microscopy represents a means to circumvent many of these limitations, by concurrently extracting information regarding the number, morphology, and relative protein content of synaptic structures. An important adaptation required for studies of human disease is coupling this approach to stereologic methods for systematic random sampling of relevant brain regions. In this review article we consider the application of multiple label fluorescence confocal microscopy to the mapping of synaptic alterations in subjects with schizophrenia and describe the application of a novel, readily automated, iterative intensity/morphological segmentation algorithm for the extraction of information regarding synaptic structure number, size, and relative protein level from tissue sections obtained using unbiased stereological principles of sampling. In this context, we provide examples of the examination of pre- and post-synaptic structures within excitatory and inhibitory circuits of the cerebral cortex

On the penetration of meridional circulation below the solar convection zone

Meridional flows with velocities of a few meters per second are observed in the uppermost regions of the solar convection zone. The amplitude and pattern of the flows deeper in the solar interior, in particular near the top of the radiative region, are of crucial importance to a wide range of solar magnetohydrodynamical processes. In this paper, we provide a systematic study of the penetration of large-scale meridional flows from the convection zone into the radiative zone. In particular, we study the effects of the assumed boundary conditions applied at the convective-radiative interface on the deeper flows. Using simplified analytical models in conjunction with more complete numerical methods, we show that penetration of the convectively-driven meridional flows into the deeper interior is not necessarily limited to a shallow Ekman depth but can penetrate much deeper, depending on how the convective-radiative interface flows are modeled.Comment: 13 pages, 5 figures. Subitted to Ap

Two-scale structure of the electron dissipation region during collisionless magnetic reconnection

Particle in cell (PIC) simulations of collisionless magnetic reconnection are presented that demonstrate that the electron dissipation region develops a distinct two-scale structure along the outflow direction. The length of the electron current layer is found to decrease with decreasing electron mass, approaching the ion inertial length for a proton-electron plasma. A surprise, however, is that the electrons form a high-velocity outflow jet that remains decoupled from the magnetic field and extends large distances downstream from the x-line. The rate of reconnection remains fast in very large systems, independent of boundary conditions and the mass of electrons.Comment: Submitted to Physical Review Letters, 4 pages, 4 figure

Fast magnetic reconnection in the plasmoid-dominated regime

A conceptual model of resistive magnetic reconnection via a stochastic plasmoid chain is proposed. The global reconnection rate is shown to be independent of the Lundquist number. The distribution of fluxes in the plasmoids is shown to be an inverse square law. It is argued that there is a finite probability of emergence of abnormally large plasmoids, which can disrupt the chain (and may be responsible for observable large abrupt events in solar flares and sawtooth crashes). A criterion for the transition from magnetohydrodynamic to collisionless regime is provided.Comment: 4 pages, 1 figur

Reuse as heuristic : from transmission to nurture in learning activity design

In recent years a combination of ever more flexible and sophisticated Web technologies and an explosion in the quantity of online content has sparked learning technologists around the world to pursue the promise of the 'reusable learning object' or RLO with the idea that RLOs could be reused in different educational contexts, thereby providing greater overall flexibility and return on investment. In 2002 the ACETS Project undertook a three-year study in the UK to investigate whether RLOs worked in practice and how the pursuit of reuse affected the teacher and their teaching. Teachers working in healthcare-related subjects in Higher and Further Education were asked to create an original learning design or activity from third-party digital resources and to reflect both on the process and its outcomes. The expectation was that teachers would be the ones selecting and reusing third-party materials. This paper describes how one of the ACETS exemplifiers reinterpreted this remit, challenged the anticipated transmissive model of learning, and instead, gave their students an opportunity to create their own original learning designs and learning activities from third-party digital resources. By describing the educational enhancements, the resulting heightened levels of critical thinking, and sensitivity to patient needs, 'reuse' will be shown to be an effective heuristic for student self-direction and professional development