89 research outputs found
Total hip arthroplasty-related osteogenic osteosarcoma: case report and review of the literature
Die lymphostatische Nephropathie: morphologische und biochemische Befunde nach experimenteller Blockade des Ductus thoracicus bei Ratten
Brain stem serotonin protects blood pressure in neonatal rats exposed to episodic anoxia
Use of the histopathology in the differential diagnosis of drowning in fresh and salty water: an experimental model establishment in rats
Postnatal age influences the ability of rats to autoresuscitate from hypoxic-induced apnea
Nuclear phospholipid signaling: phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase
Over the last 20 years, numerous studies have demonstrated the existence of nuclear phosphoinositide signaling distinct from the one at the plasma membrane. The activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphoinositide 3-kinase (PI3K), the generation of diacylglycerol, and the accumulation of the 3-phosphorylated phosphoinositides have been documented in the nuclei of different cell types. In this review, we summarize some recent studies of the subnuclear localization, mechanisms of activation, and the possible physiological roles of the nuclear PI-PLC and PI-3 kinases in the regulation of cell cycle, survival, and differentiation
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